Collagen Homeostasis of the Left Atrium: An Emerging Treatment Target to Prevent Heart Failure?

2022 ◽  
Author(s):  
Ravi B. Patel ◽  
Sanjiv J. Shah ◽  
Riccardo M. Inciardi
Keyword(s):  
Heart Failure ◽  
Left Atrium ◽  
Treatment Target

Plasma Serotonin in Heart Failure: Possible Marker and Potential Treatment Target

2017 ◽  
Vol 26 (5) ◽  
pp. 442-449 ◽  
Author(s):  
Ahmed M. Selim ◽  
Nitasha Sarswat ◽  
Iosif Kelesidis ◽  
Muhammad Iqbal ◽  
Ramesh Chandra ◽  
...  
Keyword(s):  
Heart Failure ◽  
Potential Treatment ◽  
Treatment Target ◽  
Plasma Serotonin

Remodelling of the Inferior Left Atrium and Coronary Sinus Due to Heart Failure

2009 ◽  
Vol 18 ◽  
pp. S309
Author(s):  
Lorraine Mackenzie ◽  
Dennis H. Lau ◽  
Douglas R. Kelly ◽  
Anthony G. Brooks ◽  
Pawel Kuklik ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Atrium ◽  
Coronary Sinus

scholarly journals Giant left atrium mimicking right heart failure

2007 ◽  
Vol 29 (8) ◽  
pp. 1056-1056
Author(s):  
C. Castrillo ◽  
A. Ortiz Rivas ◽  
José R. de Berrazueta
Keyword(s):  
Heart Failure ◽  
Left Atrium ◽  
Right Heart Failure ◽  
Right Heart ◽  
Giant Left Atrium

scholarly journals ULTRASOUND CRITERIA OF THE DIURETIC THERAPY EFFECTIVENESS IN CHRONIC HEART FAILURE

2018 ◽  
Vol 33 (2) ◽  
pp. 51-55
Author(s):  
V. V. Kirillova
Keyword(s):  
Heart Failure ◽  
Pulmonary Hypertension ◽  
Chronic Heart Failure ◽  
Left Atrium ◽  
Pulmonary Vein ◽  
Transthoracic Echocardiography ◽  
Diuretic Therapy ◽  
Non Invasive ◽  
Therapy Effectiveness ◽  
Vein Diameter

Evaluating the effectiveness of diuretic therapy in the small circle of blood circulation is difficult for clinicians, as distinct from that in the large circle, where it can be assessed by dynamics of peripheral edema and liver size.The aimof the study is to develop non-invasive diagnostics of venous pulmonary hypertension in order to determine the effectiveness of diuretic therapy.In addition to the standard protocol of transthoracic echocardiography, we have investigated the minimum and the maximum pulmonary vein diameter in 30 chronic heart failure patients with III functional class (NYHA) before and after 4 months of standart treatment for chronic heart failure with individual selection of torasemid. All patients received  a written consent to participate in the study. After four months of therapy, a significant improvement of the following echocardiographic parameters was revealed (р<0.05): left atrium dimension (from 42±0.88 to 37.9±0.61 mm); left atrium area (from 28.9±0.91 to 24.2±0.83 sm2); maximum pulmonary vein diameter (from 22.4±0.39 to 17.9±0.62 mm); minimum pulmonary vein diameter (from 11.9±0.27 to 8.4±0.6 mm).Thus, the transthoracic echocardiography measurement of the pulmonary vein diameter is a non-invasive objective diagnostic of venous pulmonary hypertension for evaluation diuretic therapy effectiveness.

scholarly journals Long-term clinical prognosis predictors in patients with chronic heart failure and reduced left ventricular ejection fraction

2019 ◽  
Vol 26 (5) ◽  
pp. 33-43 ◽  
Author(s):  
L. G. Voronkov ◽  
К. V. Voitsekhovska ◽  
S. V. Fedkiv ◽  
T. I. Gavrilenko ◽  
V. I. Koval
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Left Atrium ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
C Reactive Protein ◽  
Ventricular Ejection Fraction ◽  
Reactive Protein ◽  
Vasodilator Response

The aim – to identify prognostic factors for the development of adverse cardiovascular events (death and hospitalization) in patients with chronic heart failure (CHF) and left ventricular ejection fraction (LVEF) ≤ 35 % after long-term observation. Materials and methods. 120 stable patients with CHF, aged 18–75, II–IV functional classes according to NYHA, with LVEF ≤ 35 % were examined. Using multiple logistic regression according to the Cox method, we analyzed independent factors that affect the long-term prognosis of patients with heart failure. Results and discussion. During the observation period, out of 120 patients, 61 patients reached combined critical point (CCР). In the univariate regression model, predictors of CCР reaching were NYHA functional class, weigh loss of ≥ 6 % over the past 6 months, systolic and diastolic blood pressure, patient’s history of myocardial infarction, angina pectoris, anemia, number of hospitalizations over the past year and parameters reflecting the functional state of the patient (6-minute walk distance, number of extensions of the lower limb). The risk of CCP developing is significantly higher in patients with lower body mass index, shoulder circumference of a tense and unstressed arm, hip, thickness of the skin-fat fold over biceps and triceps, estimated percentage of body fat. Рredictors CCP reaching are higher levels of uric acid and C-reactive protein. Echocardiographic predictors of CCP onset were LVEF, size of the left atrium, TAPSE score, as well as its ratio to systolic pressure in the pulmonary artery, index of final diastolic pressure in the left ventricle. Also, the risk of CCP reaching is greater at lower values of the flow-dependent vasodilator response. Independent predictors of CCP onset were the circumference of the shoulder of an unstressed arm, the level of C-reactive protein in the blood, and the rate of flow-dependent vasodilator response. When analyzing the indices in 77 patients, who underwent densitometry, it was revealed that the E/E´ index, the index of muscle tissue of the extremities, the index of fat mass, and the ratio of fat mass to growth affect CCP reaching. In a multivariate analysis, taking into account densitometry indices, independent predictors of CCP onset were the size of the left atrium, the index of muscle mass of the extremities, the rate of flow-dependent vasodilator response and the presence of myocardial infarction in anamnesis. Conclusions. Independent predictors of CCP reaching in patients with CHF and LVEF ≤ 35 % are myocardial infarction in anamnesis, lower arm circumference of the arm, limb muscle mass index, flow-dependent vasodilator response, higher levels of C-reactive protein, sizes of the left atrium.

scholarly journals Hot balloon ablation of persistent atrial fibrillation with a dilated left atrium in a case of dilated cardiomyopathy

2017 ◽  
Vol 4 (2) ◽  
pp. 28
Author(s):  
Ayako Okada ◽  
Morio Shoda ◽  
Takahiro Takeuchi ◽  
Ken Kato ◽  
Wataru Shoin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Congestive Heart Failure ◽  
Dilated Cardiomyopathy ◽  
Left Atrium ◽  
Persistent Atrial Fibrillation ◽  
Left Ventricular Ejection ◽  
Lv Dysfunction ◽  
Intravenous Drip ◽  
Balloon Ablation

A 70-year-old man who developed dilated cardiomyopathy with persistent atrial fibrillation (PSAF) was admitted to our hospital. He was already drug-resistant. The left atrium (LA) was severely enlarged. The left ventricular ejection fraction (LVEF) was 39%, and contraction was severely reduced. For AF ablation, catheter ablation (CA) was used for mild to moderate LV dysfunction without severe left atrial dilatation. In severe LV dysfunction, excessive intravenous drip volume may precipitate congestive heart failure. On the other hand, shorter isolation time has been reported with balloon ablation as compared to CA. Therefore, the intravenous drip volume is small. We planned to use the balloon technique for a patient with LA dilatation and severe LV dysfunction despite another hospital not having done so. After the procedure, the pulmonary veins were successfully isolated, and congestive heart failure recovered after sinus rhythm termination. There was no recurrence of AF after the procedure. Hot balloon ablation can be effective for PSAF with severe heart failure.

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