scholarly journals Worsening renal function in acute heart failure in the context of diuretic response

2021 ◽  
Author(s):  
Johanna E. Emmens ◽  
Jozine M. Maaten ◽  
Yuya Matsue ◽  
Sylwia M. Figarska ◽  
Iziah E. Sama ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Acute Heart Failure ◽  
Worsening Renal Function ◽  
Diuretic Response

scholarly journals Any heart failure treatments associated with worsening renal function in patients admitted due to acute heart failure?

Renal Failure ◽  
2021 ◽  
Vol 43 (1) ◽  
pp. 123-127
Author(s):  
Chutatip Limkunakul ◽  
Benjawan Srisantithum ◽  
Yotin Lerdrattanasakulchai ◽  
Thanakorn Laksomya ◽  
Jatuphorn Jungpanich ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Acute Heart Failure ◽  
Worsening Renal Function

scholarly journals Impact of brain natriuretic peptide reduction on the worsening renal function in patients with acute heart failure

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0235493
Author(s):  
Kenji Yoshioka ◽  
Yuya Matsue ◽  
Takahiro Okumura ◽  
Keisuke Kida ◽  
Shogo Oishi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Brain Natriuretic Peptide ◽  
Acute Heart Failure ◽  
Natriuretic Peptide ◽  
Worsening Renal Function

scholarly journals Early drop in systolic blood pressure and worsening renal function in acute heart failure: renal results of Pre-RELAX-AHF

2011 ◽  
Vol 13 (9) ◽  
pp. 961-967 ◽  
Author(s):  
Adriaan A. Voors ◽  
Beth A. Davison ◽  
G. Michael Felker ◽  
Piotr Ponikowski ◽  
Elaine Unemori ◽  
...  
Keyword(s):  
Heart Failure ◽  
Blood Pressure ◽  
Renal Function ◽  
Systolic Blood Pressure ◽  
Acute Heart Failure ◽  
Worsening Renal Function

Cystatin C as a Biomarker of Worsening Renal Function in Acute Heart Failure: Insights from the DOSE Study

2011 ◽  
Vol 17 (8) ◽  
pp. S58 ◽  
Author(s):  
Raquel L. Bennett-Gittens ◽  
Javed Butler ◽  
Steve E. McNulty ◽  
Anekwe Onwuanyi ◽  
Adefisayo Oduwole ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Acute Heart Failure ◽  
Cystatin C ◽  
Worsening Renal Function ◽  
Dose Study

scholarly journals Ultrafiltration in Acute Heart Failure: Implications of Ejection Fraction and Early Response to Treatment From CARRESS‐HF

2020 ◽  
Vol 9 (24) ◽  
Author(s):  
Marat Fudim ◽  
Jeremy Brooksbank ◽  
Anna Giczewska ◽  
Stephen J. Greene ◽  
Justin L. Grodin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Renal Function ◽  
Ejection Fraction ◽  
Acute Heart Failure ◽  
Acute Decompensated Heart Failure ◽  
Removal Rate ◽  
Response To Treatment ◽  
Fluid Removal ◽  
Worsening Renal Function ◽  
Differential Outcomes

Background Ultrafiltration is not commonly used because of higher incidence of worsening renal function without improved decongestion. We examined differential outcomes of high versus low fluid removal and preserved versus reduced ejection fraction (EF) in CARRESS‐HF (Cardiorenal Rescue Study in Acute Decompensated Heart Failure). Methods and Results Baseline characteristics in the ultrafiltration arm were compared according to 24‐hour ultrafiltration‐based fluid removal above versus below the median. Patients were stratified by EF (≤40% or >40%). We compared clinical parameters of clinical decongestion during the hospitalization based on initial (≤24 hours) response to ultrafiltration. Cox‐proportional hazards models were used to identify associations between fluid removal <24 hours and composite of death, hospitalization, or unscheduled outpatient/emergency department visit during study follow‐up. The intention‐to‐treat analysis included 93 patients. Within 24 hours, median fluid removal was 1.89 L (Q1, Q3: 1.22, 3.16). The high fluid removal group had a greater urine output (9.08 versus 6.23 L, P =0.027) after 96 hours. Creatinine change from baseline to 96 hours was similar in both groups (0.10 mg/dL increase, P =0.610). The EF >40% group demonstrated larger increases of change in creatinine ( P =0.023) and aldosterone ( P =0.038) from baseline to 96 hours. Among patients with EF >40%, those with above median fluid removal (n=17) when compared with below median (n=17) had an increased rate of the combined end point (87.5% versus 47.1%, P =0.014). Conclusions In patients with acute heart failure, higher initial fluid removal with ultrafiltration had no association with worsening renal function. In patients with EF >40%, ultrafiltration was associated with worsening renal function irrespective of fluid removal rate and higher initial fluid removal was associated with higher rates of adverse clinical outcomes, highlighting variable responses to decongestive therapy.

Abstract 17213: Serum Alkaline Phosphatase Elevation is an Independent Predicting Factor of Worsening Renal Function in the Patients with Acute Heart Failure

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Masahiro Yamazoe ◽  
Atsushi Mizuno ◽  
Yutaro Nishi ◽  
Koichiro Niwa ◽  
Mitsuaki Isobe
Keyword(s):  
Heart Failure ◽  
Alkaline Phosphatase ◽  
Renal Function ◽  
Acute Heart Failure ◽  
Serum Alkaline Phosphatase ◽  
Elevated Serum ◽  
Biological Marker ◽  
Worsening Renal Function ◽  
Cardiovascular Center ◽  
Predicting Factor

Background: Worsening renal function (WRF) has been associated with poor outcome in the patients with acute heart failure (AHF). Recently, venous congestion had been paid attention to the important predictor of WRF in AHF. Abnormal serum alkaline phosphatase (ALP) was reported as a biological marker of liver congestion and of the extent of right sided filling pressure in AHF. In this study, we evaluated the relationship between ALP and development of WRF in AHF. Method: We enrolled consecutive patients hospitalized due to AHF in cardiovascular center of St Luke’s International Hospital, Tokyo, Japan from January, 2004 to December, 2013. We excluded the patients either on dialysis, estimated glomerular filtration rate (eGFR) under 15 ml/min/m2, or primary liver disease. We defined WRF as elevation of serum creatinine of 0.3 mg/dl or above raised from admission to discharge. We classified patients into tertiles by baseline measurements of ALP. We performed multivariate analysis to make the prediction model of WRF. Result: Total 1245 patients (age 76.4±12.9 years old, male 54.8%) were enrolled. During hospitalization, 166 (13.3%) patients developed WRF. Patients were classified into tertiles (<77, 77 to 203, >203 IU/L). Compared with the lowest ALP tertile, middle and the highest ALP tertile groups developed WRF more frequently (8.4% vs 15.5% vs 16.8%, P=0.003). In multivariate logistic regression, after adjustment of age, gender, and other risk factors, we found eGFR (Odds ratio (OR) 0.978, 95%Confidence Interval (CI) 0.967 to 0.987, P<0.001), diabetes mellitus (OR 1.83, CI 1.19 to 2.80, P=0.005), norepinephrine use (OR 1.65, CI 1.04 to 2.61, P=0.03), albumin (OR 0.507, CI 0.337 to 0.764, P=0.001), middle tertile ALP (OR 1.81, CI 1.07 to 3.06, P=0.02), and highest tertile ALP (OR 2.08, CI 1.24 to 3.48, P=0.005) compared with lowest tertile were independent variable to predict WRF. Conclusion: Our study showed that elevated serum ALP is an independent predicting factor for WRF in the patients with AHF.

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