Dietary Interventions and Nutritional Supplements for Heart Failure: A Systematic Appraisal and Evidence Map

Author(s):  
Muhammad Shahzeb Khan ◽  
Fiza Khan ◽  
Gregg C. Fonarow ◽  
Jayakumar Sreenivasan ◽  
Stephen J Greene ◽  
...  
2019 ◽  
Vol 21 (1) ◽  
pp. 69-82 ◽  

Dietary intervention is an enticing approach in the fight against cognitive impairment. Nutritional supplements and dietetic counseling are relatively easy and benign interventions, but research has not yet yielded irrefutable evidence as to their clinical utility. Heterogeneity in the results of available clinical studies, as well as methodological and practical issues, does not allow replication and generalization of findings. The paper at hand reviews only randomized clinical trials of single nutrients, multi-nutrient formulations and dietary counseling in mild cognitive impairment and dementia of the Alzheimer's type focusing on both cognitive and functional outcomes. Thus far, folate, vitamin E, Ω-3 fatty acids, and certain multi-nutrient formulations have shown some preliminary promising results; larger, well-designed trials are needed to confirm these findings before nutritional elements can be incorporated in recommended clinical guidelines.


2019 ◽  
Vol 24 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Arunima Sivanand ◽  
Wayne P. Gulliver ◽  
Chitmandeep K. Josan ◽  
Raed Alhusayen ◽  
Patrick J. Fleming

Hidradenitis suppurativa (HS) is a common inflammatory disorder characterized by recurrent, painful, and malodorous abscesses and nodules predominantly in skin folds. HS is associated with substantial morbidity and poor quality of life. There are no curative therapies, and the only approved biologic drug has variable efficacy and requires high doses, making adjunct treatments crucial. An important risk factor for disease severity is obesity. Our primary objective was to conduct a systematic review examining weight loss and dietary interventions, in HS. Our secondary objective was to examine nutritional supplements in HS.A systematic literature search was conducted using Medline, EMBASE, and the Cochrane Database. We included all study types in adults (>18 years), with a minimum sample size of 5, examining the effects of any dietary or weight loss intervention on HS severity. Two authors screened n = 1279 articles of which 9 met inclusion criteria. All included studies were observational and all interventions were associated with various measures of decreased HS severity. Patient-controlled weight loss and bariatric surgery were associated with HS regression, though a subset of patients with significant increase in panniculi experienced exacerbations and required excision of excess skin. Diets demonstrating benefit eliminated dairy and brewer’s yeast. Nutritional supplements including zinc gluconate, vitamin D, and riboflavin had a suppressive, rather than curative, effect on HS lesions in single studies. Overall, the reviewed interventions show promise as potential adjunct treatments in a HS management plan. Prospective randomized controlled trials should validate these findings.


2019 ◽  
Vol 21 (1) ◽  
pp. 69-82

Dietary intervention is an enticing approach in the fight against cognitive impairment. Nutritional supplements and dietetic counseling are relatively easy and benign interventions, but research has not yet yielded irrefutable evidence as to their clinical utility. Heterogeneity in the results of available clinical studies, as well as methodological and practical issues, does not allow replication and generalization of findings. The paper at hand reviews only randomized clinical trials of single nutrients, multi-nutrient formulations and dietary counseling in mild cognitive impairment and dementia of the Alzheimer’s type focusing on both cognitive and functional outcomes. Thus far, folate, vitamin E, Ω-3 fatty acids, and certain multi-nutrient formulations have shown some preliminary promising results; larger, well-designed trials are needed to confirm these findings before nutritional elements can be incorporated in recommended clinical guidelines.


Author(s):  
Gregory A Roth ◽  
Ian W Bolliger ◽  
Catherine W Gillespie ◽  
Ali H Mokdad

Objective: Little is known about the sodium intake of heart failure (HF) patients in the community. We used data from the Measuring Disparities in Chronic Conditions Study to examine the receipt of advice on dietary sodium and its relationship with sodium intake among adults in a large urban county. Method: We recruited adults in King County, WA using a home-address based sample as well as sampling from health facilities using medical record billing codes for key cardiovascular conditions. Survey questions addressed past medical history as well as receipt of advice and behavior related to dietary sodium. Diet history was assessed using the National Cancer Institute Diet History Questionnaire II (DHQ) for intake in the past year. We also compared responses and estimated sodium intake for those who did and did not report a diagnosis of HF. As a sensitivity analysis, we repeated our analysis using the subset of individuals who had a medical record with an ICD9 code for HF in the previous two years. Result: Our results are based on 3357 respondents from the address-based sample and 3477 from the medical record-based sample. The DHQ was completed by 940 and 1291 of these respondents, respectively. HF was reported by 290 respondents (median age 66 years, 57% male, 6.6% black race, 85% from medical record sample, 43% with a DHQ). Among those reporting a diagnosis of HF, 61% (112 of 183) reported being advised to decrease dietary sodium and 37% (67 of 183) reported being told to buy food items labeled as low salt. These rates were 30% (755 of 2515) and 13% (337 of 2515) respectively among individuals without reported HF. Estimated daily dietary sodium intake over the prior year was lower among those with HF completing a DHQ if they reported receiving counseling (mean 2.5 vs 2.8 gm if advised to cut down on salt and 2.3 vs 2.8 gm if advised to buy low salt labeled products). However, these differences were not statistically significant. Only 65% of respondents with HF (183 of 282) said they buy low salt labeled foods and 26% (61 of 290) reported eating processed, fast, or canned food at least 5 times in the prior month. Overall mean estimated daily dietary sodium intake over the prior year was 2.7 gm for respondents both with and without HF. Results were similar for those with an ICD9 code for HF. Conclusion: Our findings revealed that a large percentage of HF patients report no receipt of medical advice to reduce dietary sodium or purchase foods labeled as low salt. Moreover, the dietary intake of salt was similar for HF patients and the general population. These results point to a need for dietary interventions in HF that are both widely adopted and can actually change behavior.


2019 ◽  
Vol 171 (3) ◽  
pp. 190 ◽  
Author(s):  
Safi U. Khan ◽  
Muhammad U. Khan ◽  
Haris Riaz ◽  
Shahul Valavoor ◽  
Di Zhao ◽  
...  

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