Pharmacotherapy for Heart Failure with Reduced Ejection Fraction and Health‐Related Quality of Life: Systematic Review and Meta‐Analysis

2021 ◽  
Author(s):  
Ricky D. Turgeon ◽  
Arden R. Barry ◽  
Nathaniel M. Hawkins ◽  
Ursula M. Ellis
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Systematic Review ◽  
Ejection Fraction ◽  
Meta Analysis ◽  
Health Related Quality ◽  
Reduced Ejection Fraction ◽  
Related Quality ◽  
Health Related

scholarly journals Study protocol: systematic review and meta-analysis on the effectiveness of pharmacist intervention on health related quality of life and clinical outcomes among patients with heart failure

2020 ◽  
Author(s):  
Mulubirhan Tirfe ◽  
Alemseged Beyene ◽  
Haileselassie Berhane ◽  
Ephrem Engidawork ◽  
Tewolde Teklu
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Systematic Review ◽  
Meta Analysis ◽  
Pharmacist Intervention ◽  
Health Related Quality ◽  
Patients With Heart Failure ◽  
Related Quality ◽  
Health Related

Abstract Background: Heart failure (HF) is associated with severe complications, hospitalization, and poor quality of life. Patients with heart failure had poor physical and emotional symptoms, functional status and worse health outcomes.Objective: The aim of this systematic review and meta-analysis will be to investigate whether pharmacist intervention is effective in improving health related quality of life (HRQoL) and clinical outcomes among patients with heart failure.Method: Systematic review and meta-analysis will be conducted. Published journals in English and indexed in Medline (PubMed), Embase, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and Google scholar will be searched from 1990 to December 2019. Data will be extracted by one author and will be approved by other two authors independently. Data will be analyzed in accordance with the Cochrane handbook. Standardized mean differences will be used as an estimate of the effect size. Quality of included studies will be assessed using the modified Downs and Black checklist. Analysis for the dichotomous outcome studies will be converted into standardized mean difference and present with 95% confidence intervals. The review is approved in the International Prospective Register of Systematic Reviews (PROSPERO) with registration ID CRD42020158236.Discussion: Currently there are important gaps on the effectiveness of pharmacist intervention in improving health-related quality of life and clinical outcomes. We believe this review will provide comprehensive evidence on the effectiveness of pharmacist intervention among patients with HF.

scholarly journals Change of Health‐Related Quality of Life Over Time and Its Association With Patient Outcomes in Patients With Heart Failure

2020 ◽  
Vol 9 (17) ◽  
Author(s):  
Nariman Sepehrvand ◽  
Anamaria Savu ◽  
John A. Spertus ◽  
Jason R. B. Dyck ◽  
Todd Anderson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Summary Score ◽  
Health Related Quality ◽  
Reduced Ejection Fraction ◽  
Related Quality ◽  
Health Related ◽  
Over Time

Background Improving health‐related quality of life is an important goal in the management of patients with heart failure (HF). Defining health‐related quality of life changes over time in patients with HF with preserved (HFpEF) or reduced ejection fraction and showing their association with other important clinical events could support the use of health‐related quality of life as a measure of quantifying HF care. Methods and Results In the Alberta HEART (Heart Failure Aetiology and Analysis Team) cohort (n=621), patients were categorized into 4 subgroups: healthy controls (n=98), at risk (n=163), HFpEF (n=191), and HF with reduced ejection fraction (n=169). The change of the Kansas City Cardiomyopathy Questionnaire (KCCQ), EuroQOL 5 dimensions, and Functional Assessment of Cancer Therapy—Anemia over 12 months, and its association with a composite of death or rehospitalization within 3 years were assessed. At baseline, the KCCQ overall summary score was 73 (interquartile range, 53–86) in HFpEF and 78 (interquartile range, 56–90) in HF with reduced ejection fraction ( P =0.22). Overall, 30.5% of patients with HF experienced ≥5‐point improvements and 32.4% had ≥5‐point worsening in KCCQ overall summary score at 12 months, which did not differ between HFpEF and HF with reduced ejection fraction ( P =0.23). Clinical events were higher in patients with HF who had a decline in KCCQ over 12 months as compared with those with stable KCCQ scores (70.2% versus 52.0%, P =0.012). The results were similar for the Functional Assessment of Cancer Therapy—Anemia and EuroQOL 5 dimensions. Conclusions In patients with HF, the KCCQ quantified clinically meaningful changes over time, which were associated with important clinical outcomes in patients with HFpEF. Given the observed variability and prognostication in different patient trajectories, health‐related quality of life measures could be valuable for quantifying the quality of care in healthcare systems.

scholarly journals Health-Related Quality of Life in Comorbid Heart Failure With Reduced Ejection Fraction and Diabetes Mellitus

2019 ◽  
Vol 74 (25) ◽  
pp. 3176-3178
Author(s):  
Muthiah Vaduganathan ◽  
Gregg C. Fonarow ◽  
Stephen J. Greene ◽  
Adam D. DeVore ◽  
Nancy M. Albert ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Diabetes Mellitus ◽  
Heart Failure ◽  
Ejection Fraction ◽  
Health Related Quality ◽  
Reduced Ejection Fraction ◽  
Related Quality ◽  
Health Related

Impact of early childhood caries on oral health‐related quality of life: a systematic review and meta‐analysis

2021 ◽  
Author(s):  
Carlos Zaror ◽  
Andrea Matamala‐Santander ◽  
Montse Ferrer ◽  
Fernando Rivera‐Mendoza ◽  
Gerardo Espinoza‐Espinoza ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Early Childhood ◽  
Oral Health ◽  
Early Childhood Caries ◽  
Meta Analysis ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

Socioeconomic status and oral health‐related quality of life: A systematic review and meta‐analysis

2020 ◽  
Author(s):  
Jessica K. Knorst ◽  
Camila S. Sfreddo ◽  
Gabriela F. Meira ◽  
Fabrício B. Zanatta ◽  
Mario V. Vettore ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Socioeconomic Status ◽  
Oral Health ◽  
Meta Analysis ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related
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