Clinical profile and prognostic significance of natriuretic peptide trajectory following hospitalization for worsening chronic heart failure: findings from the ASTRONAUT trial

2015 ◽  
Vol 17 (1) ◽  
pp. 98-108 ◽  
Author(s):  
Stephen J. Greene ◽  
Aldo P. Maggioni ◽  
Gregg C. Fonarow ◽  
Scott D. Solomon ◽  
Michael Böhm ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Natriuretic Peptide ◽  
Prognostic Significance ◽  
Clinical Profile ◽  
Trajectory Following

Visit-to-Visit B-Type Natriuretic Peptide Variability during the Previous Year Has Independent Prognostic Value in Patients with Stable Chronic Heart Failure

Cardiology ◽  
2019 ◽  
Vol 143 (3-4) ◽  
pp. 92-99 ◽  
Author(s):  
Nobuyuki Kagiyama ◽  
Takuya Yuri ◽  
Akihiro Hayashida ◽  
Atsushi Hirohata ◽  
Keizo Yamamoto ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Natriuretic Peptide ◽  
Risk Score ◽  
Prognostic Value ◽  
Prognostic Significance ◽  
Multivariable Analysis ◽  
Hazard Ratio ◽  
Stable Phase ◽  
Wide Variability

Background: There is wide variability of visit-to-visit (V2V) B-type natriuretic peptide (BNP) in patients with chronic heart failure (CHF), even when they are stable. The prognostic significance of V2V-BNP variability has not been investigated. We aimed to test whether V2V-BNP variability during the stable period of CHF has prognostic value regardless of BNP level. Methods: In 278 stable outpatients (75 ± 10 years, 65% male) with CHF, we studied V2V-BNP variability, which was defined as the coefficient of variance of BNP values measured during 1 year before enrollment. All-cause death and rehospitalization due to HF were considered the primary endpoint. Results: The median V2V-BNP variability was 25.7% (IQR: 19.2–34.4%). During the follow-up period (median 3.2 years), 100 patients reached the endpoint and those with high V2V-BNP variability (≥25.7%) had a significantly higher rate of events (p = 0.001). CHF severity in terms of BNP level and MAGGIC risk score was not significantly different between those with high and low V2V-BNP variability. Multivariable analysis showed that high V2V-BNP variability was independently associated with increased event rates even after adjustment for other known prognostic predictors, including BNP (hazard ratio 1.90, p = 0.003), or for MAGGIC risk score and BNP (hazard ratio 1.72, p = 0.010). The hazard for the outcome consistently increased as V2V-BNP variability increased, with a marked increase up to about 30%. Conclusions: Even in the stable phase of CHF, V2V-BNP variability was associated with worse long-term outcomes, independent of BNP level.

514 Prognostic significance of bioelectrical evaluation of body composition in chronic heart failure

2003 ◽  
Vol 2 (1) ◽  
pp. 105
Author(s):  
F MASSARI ◽  
P GUIDA ◽  
F MASTROPASQUA ◽  
M IACOVIELLO ◽  
B RIZZON ◽  
...  
Keyword(s):  
Heart Failure ◽  
Body Composition ◽  
Chronic Heart Failure ◽  
Prognostic Significance

Attenuation of Compensation of Endogenous Cardiac Natriuretic Peptide System in Chronic Heart Failure

Circulation ◽  
1997 ◽  
Vol 96 (2) ◽  
pp. 509-516 ◽  
Author(s):  
Takayoshi Tsutamoto ◽  
Atsuyuki Wada ◽  
Keiko Maeda ◽  
Tomoko Hisanaga ◽  
Yukiharu Maeda ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Natriuretic Peptide ◽  
Peptide System ◽  
Natriuretic Peptide System
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