scholarly journals Autophagy stimulation and intracellular sodium reduction as mediators of the cardioprotective effect of sodium–glucose cotransporter 2 inhibitors

2020 ◽  
Vol 22 (4) ◽  
pp. 618-628 ◽  
Author(s):  
Milton Packer
Keyword(s):  
Intracellular Sodium ◽  
Cardioprotective Effect ◽  
Sodium Reduction ◽  
Sodium Glucose Cotransporter

Electrochemical analysis of renal Na+-glucose cotransport in salamander proximal tubules

1987 ◽  
Vol 252 (1) ◽  
pp. F154-F169
Author(s):  
N. Morgunov ◽  
E. L. Boulpaep
Keyword(s):  
Membrane Resistance ◽  
Electrochemical Analysis ◽  
Membrane Potentials ◽  
Intracellular Sodium ◽  
Ambystoma Tigrinum ◽  
Luminal Membrane ◽  
Sodium Activity ◽  
Sodium Glucose Cotransporter ◽  
Electrical Gradient ◽  
Intracellular Glucose

The changes in electrical membrane parameters and intracellular sodium activity associated with the absorption of D-glucose were studied in the isolated perfused proximal tubule of the Ambystoma tigrinum kidney. The addition of 10 mM D-glucose to a substrate-free luminal perfusate depolarized the basolateral and luminal membrane potentials by -16.2 +/- 0.9 mV and +20.4 +/- 0.9 mV, respectively (P less than 0.01), increased intracellular sodium activity (acellNa) by 5.1 +/- 0.8 mM (P less than 0.01) and significantly (P less than 0.01) decreased luminal membrane resistance from 2,859 +/- 454 to 1,483 +/- 120 omega X cm2. Both the electrogenic response and the change in acellNa induced by luminal glucose were a saturating function of luminal glucose and sodium concentrations. The electrogenic response to luminal glucose was sensitive to intracellular glucose concentration and the change in acellNa induced by luminal glucose was sensitive to intracellular sodium concentrations. Within the physiological range of membrane potentials and studied, the sodium-glucose cotransporter is more sensitive to a decrease in a favorable electrical gradient than to an increase in a favourable chemical gradient for sodium across the luminal membrane.

Cardioprotective Effect of Intraischemic Therapeutic Hypothermia in Primary Cardiomyocytes

2016 ◽  
Vol 64 (S 02) ◽  
Author(s):  
J. Krech ◽  
S.-B. Cormann ◽  
C. Walker ◽  
G. Tong ◽  
F. Berger ◽  
...  
Keyword(s):  
Therapeutic Hypothermia ◽  
Cardioprotective Effect

Cardioprotective Effect of Naringin in Mice Treated with Doxorubicin

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
TK Reddy ◽  
I Nagaraju ◽  
KH Kumar ◽  
V Lokanatha ◽  
CD Reddy ◽  
...  
Keyword(s):  
Cardioprotective Effect
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