scholarly journals Is plasma renin activity associated with worse outcomes in acute heart failure? A secondary analysis from the BLAST‐AHF trial

2019 ◽  
Vol 21 (12) ◽  
pp. 1561-1570 ◽  
Author(s):  
Rayan Jo Rachwan ◽  
Javed Butler ◽  
Sean P. Collins ◽  
Gad Cotter ◽  
Beth A. Davison ◽  
...  
Keyword(s):  
Heart Failure ◽  
Plasma Renin Activity ◽  
Acute Heart Failure ◽  
Secondary Analysis ◽  
Plasma Renin ◽  
Renin Activity

scholarly journals Plasma renin activity in patients with heart failure and reduced ejection fraction on optimal medical therapy

2017 ◽  
Vol 18 (3) ◽  
pp. 147032031772991 ◽  
Author(s):  
Petra Nijst ◽  
Frederik H Verbrugge ◽  
Pieter Martens ◽  
Philippe B Bertrand ◽  
Matthias Dupont ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Plasma Renin Activity ◽  
Healthy Volunteers ◽  
Cardiovascular Mortality ◽  
Plasma Renin ◽  
Renin Activity ◽  
Prognostic Impact ◽  
Renin Angiotensin ◽  
Reduced Ejection Fraction

Background: Renin-angiotensin-aldosterone system (RAAS) activation in heart failure with reduced ejection fraction (HFREF) is detrimental through promotion of ventricular remodeling and salt and water retention. Aims: The aims of this article are to describe RAAS activity in distinct HFREF populations and to assess its prognostic impact. Methods: Venous blood samples were prospectively obtained in 76 healthy volunteers, 72 patients hospitalized for acute decompensated HFREF, and 78 ambulatory chronic HFREF patients without clinical signs of congestion. Sequential measurements were performed in patients with acute decompensated HFREF. Results: Plasma renin activity (PRA) was significantly higher in ambulatory chronic HFREF (7.6 ng/ml/h (2.2; 18.1)) compared to patients with acute decompensated HFREF (1.5 ng/ml/h (0.8; 5.7)) or healthy volunteers (1.4 ng/ml/h (0.6; 2.3)) (all p < 0.05). PRA was significantly associated with arterial blood pressure and renin-angiotensin system blocker dose. A progressive rise in PRA (+4 ng/ml/h (0.4; 10.9); p < 0.001) was observed in acute decompensated HFREF patients after three consecutive days of decongestive treatment. Only in acute HFREF were PRA levels associated with increased cardiovascular mortality or HF readmissions ( p = 0.035). Conclusion: PRA is significantly elevated in ambulatory chronic HFREF patients but is not associated with worse outcome. In contrast, in acute HFREF patients, PRA is associated with cardiovascular mortality or HF readmissions.

scholarly journals Plasma renin activity, response to aliskiren, and clinical outcomes in patients hospitalized for heart failure: the ASTRONAUT trial

2017 ◽  
Vol 20 (4) ◽  
pp. 677-686 ◽  
Author(s):  
Muthiah Vaduganathan ◽  
Baljash Cheema ◽  
Erin Cleveland ◽  
Kamya Sankar ◽  
Haris Subacius ◽  
...  
Keyword(s):  
Heart Failure ◽  
Plasma Renin Activity ◽  
Clinical Outcomes ◽  
Plasma Renin ◽  
Renin Activity ◽  
Activity Response

scholarly journals The diurnal rhythm of plasma aldosterone and plasma renin activity in patients with congestive heart failure.

1977 ◽  
Vol 24 (5) ◽  
pp. 513-518 ◽  
Author(s):  
TETSUO SAKAMAKI ◽  
SHUICHI ICHIKAWA ◽  
SACHIKO TONOOKA ◽  
HIDEYO MATSUO ◽  
YOSHIRO SUGAI ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Plasma Renin Activity ◽  
Diurnal Rhythm ◽  
Plasma Renin ◽  
Plasma Aldosterone ◽  
Renin Activity
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