scholarly journals December 2017 at a glance: left ventricular ejection fraction, exercise capacity, peripartum cardiomyopathy

2017 ◽  
Vol 19 (12) ◽  
pp. 1562-1563 ◽  
Author(s):  
Marco Metra
Keyword(s):  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Exercise Capacity ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction

Left ventricular function and exercise capacity after arterial switch operation for transposition of the great arteries: a systematic review and meta-analysis

2018 ◽  
Vol 28 (7) ◽  
pp. 895-902 ◽  
Author(s):  
Sebastiaan W. van Wijk ◽  
Mieke M. Driessen ◽  
Folkert J. Meijboom ◽  
Pieter A. Doevendans ◽  
Paul H. Schoof ◽  
...  
Keyword(s):  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Exercise Capacity ◽  
Arterial Switch Operation ◽  
Left Ventricular ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Ventricular Ejection Fraction ◽  
Arterial Switch ◽  
Switch Operation

AbstractBackgroundThe arterial switch operation for transposition of the great arteries was initially believed to be an anatomical correction. Recent evidence shows reduced exercise capacity and left ventricular function in varying degrees in the long term after an arterial switch operation.ObjectiveTo perform a meta-analysis on long-term exercise capacity and left ventricular ejection fraction after an arterial switch operation.MethodsA literature search was performed to cover all studies on patients who had undergone a minimum of 6 years of follow-up that reported either left ventricular ejection fraction, peak oxygen uptake, peak workload, and/or peak heart rate. A meta-analysis was performed if more than three studies reported the outcome of interest.ResultsA total of 21 studies reported on the outcomes of interest. Oxygen uptake was consistently lower in patients who had undergone an arterial switch operation compared with healthy controls, with a pooled average peak oxygen uptake of 87.5±2.9% of predicted. The peak heart rate was also lower compared with that of controls, at 92±2% of predicted. Peak workload was significantly reduced in two studies. Pooled left ventricular ejection fraction was normal at 60.7±7.2%.ConclusionExercise capacity is reduced and left ventricular ejection fraction is preserved in the long term after an arterial switch operation for transposition of the great arteries.

scholarly journals Immunosuppression therapy in the management of peripartum cardiomyopathy: A case series and literature review

2016 ◽  
Vol 9 (4) ◽  
pp. 174-176
Author(s):  
Joyee Basu ◽  
Christopher Redman ◽  
Oliver Ormerod
Keyword(s):  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Left Ventricular Systolic Dysfunction ◽  
Case Series ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
High Dose ◽  
Ventricular Ejection Fraction

Peripartum cardiomyopathy is a heart failure syndrome occurring late in pregnancy or during the early post-natal period. The pathophysiology of peripartum cardiomyopathy is not fully understood and various mechanisms have been postulated including an underlying inflammatory process. We here report four cases presenting with acute left ventricular systolic dysfunction. Three out of four of the patients presented with a left ventricular ejection fraction <30% and one with a left ventricular ejection fraction of 35%. All made a full clinical recovery following treatment with high-dose intravenous steroids. This case series adds to the growing body of evidence for the role for immunosuppressants in the management of peripartum cardiomyopathy.

scholarly journals Peripartum cardiomyopathy: An analysis of clinical profiles and outcomes from a tertiary care centre in southern India

2019 ◽  
Vol 13 (4) ◽  
pp. 179-184 ◽  
Author(s):  
Aditya John Binu ◽  
Sudha Jasmine Rajan ◽  
Swati Rathore ◽  
Manisha Beck ◽  
Annie Regi ◽  
...  
Keyword(s):  
Left Ventricular Ejection Fraction ◽  
Ejection Fraction ◽  
Tertiary Care ◽  
Left Ventricular ◽  
Peripartum Cardiomyopathy ◽  
Ventricular Ejection ◽  
Left Ventricular Ejection ◽  
Tertiary Care Centre ◽  
Ventricular Ejection Fraction ◽  
Clinical Profiles

Peripartum cardiomyopathy is a syndrome of maternal heart failure with decreased left ventricular ejection fraction affecting maternal and fetal well-being. We analysed clinical profiles and outcomes in women with peripartum cardiomyopathy enrolled retrospectively from a tertiary care centre in southern India (1 January 2008–31 December 2014). The incidence of peripartum cardiomyopathy was one case per 1541 live births. Fifty-four women with a mean age of 25.5 years and mean gestational age of 35.4 weeks were recruited; 35 were primigravidae. Maternal and fetal deaths occurred in 9.3% and 24.1% of subjects, respectively. Mild-to-moderate maternal anaemia (80–110 g/L) was associated with fetal mortality (p = 0.02). Reduced left ventricular ejection fraction (<30%, p = 0.04) and cardiogenic shock (p = 0.01) were significantly associated with adverse maternal outcomes. Forty per cent of women were followed up after 24.2 ± 17.7 months, and in these women a significant increase in left ventricular ejection fraction was seen (mean 16.4%, p < 0.01); all were asymptomatic. Peripartum cardiomyopathy with poor left ventricular ejection fraction and shock is associated with adverse maternal outcomes, while non-severe maternal anaemia predisposes to adverse fetal outcomes. Significant left ventricular ejection fraction recovery occurred on follow-up.

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