scholarly journals Six‐months immunogenicity of BNT162b2 mRNA vaccine in heart transplanted and ventricle assist device‐supported patients

2022 ◽  
Author(s):  
Osnat Itzhaki Ben Zadok ◽  
Aviv A. Shaul ◽  
Binyamin Ben‐Avraham ◽  
Vicky Yaari ◽  
Haim Ben Zvi ◽  
...  
1988 ◽  
Vol 36 (03) ◽  
pp. 146-150 ◽  
Author(s):  
L. Segesser ◽  
B. Leskosek ◽  
F. Redha ◽  
E. Hänseler ◽  
E. Garcia ◽  
...  

Author(s):  
Julianna F Lampropulos ◽  
Yun Wang ◽  
Mayur Desai ◽  
Nancy Kim ◽  
Jose A Barreto-Filho ◽  
...  

Background: Over the last decade, left ventricle assist device (LVAD) technology has improved substantially, resulting in smaller devices requiring less invasive procedures, which has broadened its clinical indications to frail populations. During this time of technological advancement, we examined trends in use, mortality, and associated costs of LVADs among Medicare beneficiaries. Methods: Inpatient Medicare standard analytic files were used to identify 100% of fee-for-service (FFS) patients aged ≥65 years that received LVAD (ICD-9-CM codes 37.60, 37.62, 37.65, 37.66 and 37.68) from 1999 to 2008. We constructed a denominator file from Medicare administrative data to report operative rates per 1,000,000 beneficiary-years. Length of stay, hospital mortality, thirty-day and one-year mortality were ascertained through corresponding vital status files. Costs were defined as hospital payments made by Medicare. Results: Among Medicare FFS patients, the overall LVAD procedure rate increased from 13.8 per million beneficiary-years (365 procedures) in 1999 to 19.8 per million beneficiary-years (548 procedures) in 2008, a relative increase of 44 %. In addition, between 1999 and 2008 overall length of stay increased from 19.1 days to 23.8 days; hospital mortality decreased from 42.5% to 33.4%, 30-day mortality decreased from 38.9% to 30.7% and one-year mortality decreased from 54% to 47.1%. Total CMS payments for the hospitalizations in which LVADs were placed increased from $20,188,880 ($55,312/patient) in 1999 to $71,050,392 ($129,654/patient) in 2008. Over the study period, LVAD use increased in all age groups, most strikingly among the ≥75 years old, in whom incidence increased from 151 procedures in 1999 to 192 procedures in 2008, representing 35% of the LVAD implantation in the Medicare population in 2008. Conclusions: From 1999 to 2008, LVAD use increased substantially with a decrease in hospital, 30-day and one-year mortality.


2016 ◽  
Vol 70 (1) ◽  
Author(s):  
Franco Tarro Genta ◽  
Elena Colajanni ◽  
Pierluigi Sbarra ◽  
Massimo Tidu ◽  
Mauro Rinaldi ◽  
...  

Endothelial function measured with brachial ultrasound (BU) is a validated prognostic factor in heart failure patients. LVAD (left ventricle assist device) application is a promising surgical technique to treat refractory heart failure patients both as a bridge to heart transplantation or as destination therapy. Clinical recovery in such patients may be associated to normal endothelial function measured by BU but, as recently reported, only in pulsatile flow LVAD patients. The present paper report a case of normal endothelial function even in a axial LVAD patient.


2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Darshan Doshi ◽  
Raja Hatem ◽  
Amirali Masoumi ◽  
Dimitri Karmapaliotis

Abstract Background Septal haematomas causing left ventricular or biventricular outflow obstruction are rare but known complications of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) and can be life-threatening. Case summary In this case, we describe the formation of a septal haematoma during retrograde CTO PCI. The patient was initially managed conservatively but became progressively unstable, for which she underwent coiling of the inflow and outflow of the septal perforator. Despite coiling, she developed near complete right ventricular outflow obstruction (based on echocardiography). She was successfully managed with a percutaneous right ventricle assist device, with subsequent resolution of the outflow obstruction. Discussion Septal haematomas with resultant outflow obstruction have been uniformly fatal. In our case, the use of a percutaneous right ventricle assist device was life-saving.


2020 ◽  
Vol 21 (5) ◽  
pp. 491-497 ◽  
Author(s):  
Mihai Strachinaru ◽  
Daniel J Bowen ◽  
Alina Constatinescu ◽  
Olivier C Manintveld ◽  
Jasper J Brugts ◽  
...  

Abstract Aims A significant proportion of left ventricle assist device (LVAD) patients have very difficult transthoracic echocardiographic images. The aim of this study was to find an echocardiographic window which would provide better visualization of the heart in LVAD patients with limited acoustic windows. Methods and results Based on the anatomic relationships in LVAD patients, a right intercostal transhepatic approach was proposed. By using a computer simulator, we searched for the appropriate probe orientation. Further, 15 ambulatory LVAD patients (age 56 ± 15 years, 73% males) underwent two echocardiographic studies: one normal transthoracic echocardiography following the institutional protocol (Echo 1) and a second study which included the transhepatic approach (Echo 2). The two exams were performed by two different sonographers and the results validated by a third observer for agreement. The transhepatic intercostal window was feasible in all patients, with an image quality allowing good visualization of structures in 93%. Precise quantification of the left ventricular (LV) and right ventricular (RV) function was achieved more often in the Echo 2 (10 vs. 3 patients for LV, P = 0.03 and 14 vs. 8 patients for RV, P = 0.04). A significant difference existed also in the quantification of the LVAD inflow cannula flow by pulsed Doppler (11 patients in Echo 2 vs. 3 patients in Echo 1, P = 0.009). Conclusion This is the first study describing a new echocardiographic window in LVAD patients. The transhepatic window may provide better quantification of left and RV dimensions and function and improvement in Doppler interrogation of the inflow cannula.


2020 ◽  
Vol 26 (10) ◽  
pp. S128
Author(s):  
Kathir Balakumaran ◽  
Raul Angel Garcia ◽  
Tracy Schwab ◽  
Safwan Gaznabi ◽  
Jennifer T. Dahm ◽  
...  

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