scholarly journals Acute heart failure and iron deficiency: a prospective, multicentre, observational study

2021 ◽  
Author(s):  
Dirk H. Dalen ◽  
Johannes A. Kragten ◽  
Mireille E. Emans ◽  
Clara E.E. Ofwegen‐Hanekamp ◽  
Claudia C.R. Klaarwater ◽  
...  
2008 ◽  
Vol 10 (4) ◽  
pp. 209-213 ◽  
Author(s):  
Juhani Rossinen ◽  
Veli-Pekka Harjola ◽  
Krista Siirilä-Waris ◽  
Johan Lassus ◽  
John Melin ◽  
...  

2021 ◽  
Author(s):  
Igor I Chernov ◽  
Iliya A Ivashchenko ◽  
Irina A Mandel

Objective: The aim of the study was to assess the safety and efficacy of a normothermic cardioplegia solution N trademark use and obtain additional information about dosing regimens during normothermic or mild hypothermic cardiac surgery. Methods: A retrospective observational study included 150 cardio surgery patients. The primary endpoint was the intraoperative acute heart failure development. The secondary endpoints were the postoperative Troponin T concentrations, the need for catecholamine support, and the repeated infusion of a cardioplegia solution. Results: The duration of aortic cross-clamping varied from 17 to 154 minutes, median 59 [interquartile range, 46 - 73] minutes. Spontaneous sinus rhythm recovery was observed in 136 (90.7%) patients. Intraoperative acute heart failure was observed in 1 case. The Troponin T concentrations were 0.331 plus-or-minus sign 0.143 ng/mL after surgery. Mortality was 2% (3 patients). Eight patients received an additional volume of N trademark solution to maintain asystole. Among 16 patients with a cross-clamp duration greater than 90 minutes epinephrine was used in 3 (18.8%) patients in doses of more than 0.05 mcg/kg/min. Among 134 patients cross-clamp duration less than 90 minutes the catecholamine support was used in 4 (3%) patients, p=0.027. Conclusions: A primary single-dose infusion of cardioplegia solution N trademark provides myocardial protection for 59 (interquartile range, 46-73) minutes and up to 154 minutes. The catecholamine support in the group of aortic cross-clamp duration less than 90 minutes was used lesser than in the group of aortic cross-clamp duration greater than 90 minutes (3% and 18.8%, respectively). The cardioprotection during cardiopulmonary bypass surgery especially in elderly patients with concomitant disease needs to be confirmed in future investigations.


2016 ◽  
Vol 109 (8-9) ◽  
pp. 449-456 ◽  
Author(s):  
Najla Lemachatti ◽  
Anne-Laure Philippon ◽  
Benjamin Bloom ◽  
Pierre Hausfater ◽  
Bruno Riou ◽  
...  

2021 ◽  
Author(s):  
Emmanuelle Berthelot ◽  
Amaury Broussier ◽  
Thibaud Damy ◽  
Cristiano Donadio ◽  
Stephane Cosson ◽  
...  

Abstract Context: A growing number of elderly patients hospitalized for Acute Heart Failure (AHF) are being managed in cardiogeriatrics departments, but their characteristics and prognosis are poorly known. This study aimed to investigate the profile and outcome (rehospitalization at 90 days) of patients hospitalized for AHF in cardiogeriatrics departments in the Val-de-Marne area in the suburbs of Paris, and to compare them to AHF patients hospitalized in cardiology departments in the same area. Methods: Observational study, ICREX-94, conducted in seven cardiology departments in France and three specific cardiogeriatrics departments in Val-de-Marne. Results: A total of 308 patients were hospitalized for AHF between October 2017 and January 2019. During the 90 days following discharge, 29.6% patients were readmitted to the hospital. Compared with patients hospitalized in cardiology departments, patients in cardiogeriatrics departments were older (p<0.001), less independent (living more often alone or in an institution) (p<0.001), more often depressed (p<0.001), had more often major neurocognitive disorder (p<0.001), had a higher Human Development Index (HDI, p<0.001), and were less often diagnosed with amyloidosis (p<0.001). There was no difference in outcome whether patients were discharged from cardiology or cardiogeriatrics departments. The most frequent precipitating factors underlying AHF decompensation between the first and second hospitalization were arrhythmia and infection.Conclusion: AHF patients discharged from cardiogeriatrics departments, compared to cardiology departments, showed clinical differences but had the same prognosis regarding AHF rehospitalization at 90 days.


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