scholarly journals Effect of angiotensin receptor neprilysin inhibitors on left atrial remodeling and prognosis in heart failure

2021 ◽  
Author(s):  
Yuxi Sun ◽  
Shuang Song ◽  
Yanli Zhang ◽  
Wenqiong Mo ◽  
Xinxin Zhang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Left Atrial ◽  
Atrial Remodeling ◽  
Angiotensin Receptor ◽  
Left Atrial Remodeling

scholarly journals Left Atrial Remodeling and Function in Advanced Heart Failure With Preserved or Reduced Ejection Fraction

2015 ◽  
Vol 8 (2) ◽  
pp. 295-303 ◽  
Author(s):  
Vojtech Melenovsky ◽  
Seok-Jae Hwang ◽  
Margaret M. Redfield ◽  
Rosita Zakeri ◽  
Grace Lin ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Left Atrial ◽  
Advanced Heart Failure ◽  
Atrial Remodeling ◽  
Left Atrial Remodeling ◽  
Reduced Ejection Fraction ◽  
And Function

Left Atrial Remodeling and Recurrence of Congestive Heart Failure in Patients Initially Diagnosed with Heart Failure

2013 ◽  
Vol 31 (8) ◽  
pp. 936-940 ◽  
Author(s):  
Kazuto Yamaguchi ◽  
Hiroyuki Yoshitomi ◽  
Shimpei Ito ◽  
Saki Ito ◽  
Tomoko Adachi ◽  
...  
Keyword(s):  
Heart Failure ◽  
Congestive Heart Failure ◽  
Left Atrial ◽  
Atrial Remodeling ◽  
Left Atrial Remodeling

Left Atrial Remodeling and Recurrence of Congestive Heart Failure in Patients with Atrial Fibrillation

2016 ◽  
Vol 22 (9) ◽  
pp. S175
Author(s):  
Kazuto Yamaguchi ◽  
Maidar Tumenbayar ◽  
Hiroyuki Yoshitomi ◽  
Taiji Okada ◽  
Taku Nakamura ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Congestive Heart Failure ◽  
Left Atrial ◽  
Atrial Remodeling ◽  
Left Atrial Remodeling

scholarly journals Galectin-3 in Heart Failure with Preserved Ejection Fraction and Persistent Atrial Fibrillation Versus Sinus Rhythm. Correlation with Left Atrial Volume and N-Terminal Pro B-Type Natriuretic Peptide

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Bertoni M ◽  
◽  
Traini AM ◽  
Celli A ◽  
Bini C ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Left Atrial ◽  
Independent Predictor ◽  
Left Atrial Volume ◽  
Atrial Remodeling ◽  
Preserved Ejection Fraction ◽  
Atrial Volume ◽  
Left Atrial Remodeling ◽  
Galectin 3

Background: Galectin-3 (Gal-3) is considered both a profibrotic biomarker in Heart Failure with preserved Ejection Fraction (HFpEF) and a biomarker of atrial remodeling in Atrial Fibrillation (AF). The Left Atrial Volume Index (LAVI) is an echocardiographic parameter considered an index of left atrial remodeling. Aim of this study was to analyse the relation of Gal-3 levels with both LAVI and N-Terminal Pro B-Type Natriuretic Peptide (NT-proBNP) in patients with HFpEF and Persistent AF (HFpEF-PAF). Methods: Serum Gal-3 and NT-proBNP, along with LAVI were measured. A comparison of such parameters between 49 patients with HFpEF-PAF and 53 patients with HFpEF and sinus rhythm (HEpEF-SR) was made. Results: Galectin-3, NT-proBNP and LAVI were significantly higher in patients with HFpEF-PAF compared to HFpEF-SR (23±7 ng/mL vs 19.5±8.5 ng/mL, p=0.027; 3,406.8±2,321.9 pg/mL vs 1,459.6±1,372 pg/mL, p<0.001; 40.1±11mL/m² vs 28.4±7.7 mL/m², p<0.001, respectively). In HFpEF-PAF, Gal- 3 showed a significant correlation with both NT-proBNP (r=0.40, p=0.0038) and LAVI (r=0.28, p=0.044). We found a significant association between patients with higher levels of Gal-3 >17.8 ng/mL and HFpEF-PAF (p=0.002). Finally, a multivariate logistic regression analysis adjusted for age, sex and traditional clinical AF risk factors showed that Gal-3 >17,8 ng/mL (OR 3.862, 95% CI 1.416 to 10.532, p=0.008) was an independent predictor of PAF. Conclusions: In patients with HFpEF-PAF Gal-3 was higher and related with both NT-proBNP and LAVI. The latter correlation may be relevant because LAVI is considered an index of left atrial remodeling. Moreover, higher levels of Gal-3>17,8 ng/mL were an independent predictor of PAF.

Abstract 17226: Increased Risk of Heart Failure Associated With Left Atrial Remodeling Without Known Atrial Fibrillation

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Jodi Edwards ◽  
Jiming Fang ◽  
Jeff S Healey ◽  
Kathy Yip ◽  
Lisa Mielniczuk ◽  
...  
Keyword(s):  
Heart Failure ◽  
Atrial Fibrillation ◽  
Left Atrial ◽  
Left Ventricular ◽  
Administrative Databases ◽  
Risk Scores ◽  
Atrial Remodeling ◽  
Left Atrial Remodeling ◽  
Lv Dysfunction ◽  
Increased Risk

Background: Atrial fibrillation (AF) significantly increases risk for heart failure (HF) and independently increases mortality and adverse in-hospital outcomes in HF patients. Validated clinical risk scores (ARC2H) can predict HF in patients with AF, but are limited in application as AF is frequently clinically silent or undetected. However, AF may be preceded by significant preclinical remodeling (left atrial enlargement (LAE) or excessive atrial ectopy (EAE)). Whether LAE and EAE are associated with HF prior to AF is unclear. Method(s): We analyzed consecutive adults >65 years with outpatient echocardiography or Holter at 11 Ontario community cardiology clinics (2010-2017). Exclusions were history of AF, anticoagulation, pacemaker/ICD/ILR, and prosthetic valve. Using linked administrative databases, we assessed 5-year rates of HF (primary) and incident AF and death (secondary) associated with LAE and EAE and among subgroups (M vs. F; <75 vs. >75; CHADS-VASC 0-2 vs. 3-6). Competing risks cox proportional hazards estimated adjusted hazard of HF for severe LAE: >47mm (M);>52mm (F)) or increased APBs/hour (EAE: >30) or both LAE and EAE, adjusting for age, vascular comorbidities and left ventricular (LV) dysfunction. Results: In 28,261 adults (mean 73+/-6 years), direct age-adjusted survival was reduced for those with severe LAE and EAE. 5-year rates of HF were increased for severe (8.8%) vs. moderate (3.5%) and mild (1.4%) LAE and for those with excessive (3.8%) vs. normal (2.5%) ectopy. For both LAE and EAE, those >75 and with a CHADS score 3-6 showed marked increases in HF at 5 years compared to <75 (LAE: 10.6% vs. 7.9%; EAE: 4.3% vs. 1.9%) and CHADS score 0-2 (LAE:21.4% vs. 6.6%; EAE: 8.9% vs. 2.4%). Severe LAE increased hazard of HF 2-fold (HR=2.07; p<.0001), and incident AF over 3-fold (HR= 3.43; p<.0001) and EAE increased hazard of HF (HR=1.31; p<.0001) and incident AF (HR=1.13; p<.0001). Those with both LAE and EAE showed an over 3-fold increased hazard of HF (HR=3.28; p<.0014). Conclusions: Severe LAE and EAE without known AF are associated with increased risk of HF and AF after adjusting for LV dysfunction, particularly for those >75 and with high vascular burden. These data have implications for risk stratification, AF screening, and trials for HF prevention in individuals with left atrial remodeling.

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