scholarly journals Reverse electromechanical modelling of diastolic dysfunction in spontaneous hypertensive rat after sacubitril/valsartan therapy

2020 ◽  
Vol 7 (6) ◽  
pp. 4040-4050
Author(s):  
Yen‐Ling Sung ◽  
Ting‐Tse Lin ◽  
Jhen‐Yang Syu ◽  
Hung‐Jui Hsu ◽  
Kai‐Yuan Lin ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Spontaneous Hypertensive Rat ◽  
Hypertensive Rat

Plasma Glucagon and Free Fatty Acid Responses to a Glucose Load in the Obese Spontaneous Hypertensive Rat (SHROB) Model of Metabolic Syndrome X

2002 ◽  
Vol 227 (3) ◽  
pp. 164-170 ◽  
Author(s):  
Rodney A. Velliquette ◽  
Richard J. Koletsky ◽  
Paul Ernsberger
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Metabolic Syndrome X ◽  
Molar Ratio ◽  
Syndrome X ◽  
Oral Glucose ◽  
Plasma Glucagon ◽  
Glucose Load ◽  
Spontaneous Hypertensive Rat ◽  
Hypertensive Rat

Metabolic Syndrome X is a cluster of abnormalities including insulin resistance, hyperlipidemia, hypertension, and obesity. We sought to determine if excess plasma glucagon and free fatty acids (FFA) might contribute to the insulin resistance in the obese spontaneous hypertensive rat (SHROB), a unique animal model of leptin resistance and metabolic Syndrome X. SHROB were extremely hyperinsulinemic and mildly glucose intolerant compared with lean SHR. SHROB had elevated fasting plasma glucagon and FFA, and showed paradoxical responses to an oral glucose challenge, with increased glucagon at 30 and 60 min postchallenge (200% ± 45% and 91% ± 13%, respectively; n = 9). In lean SHR, glucagon was nearly unchanged by glucose loading (<30% increase, P > 0.05; n = 5). Plasma FFA were not affected by a glucose load in SHROB, whereas SHR showed a decrease of 40% ± 6% (n = 5–9). The I/G molar ratio changed in opposite directions in the two genotypes, with a decrease in SHROB at 30 and 60 min, in contrast to the appropriate increase at 30 and 60 min postchallenge in the lean SHR (P < 0.01; n = 5–9). Administration of 500 ng/kg exogenous glucagon to SHR raised glucagon 56% ± 5% to a level that was similar to fasting SHROB. This level of circulating glucagon was sufficient to elevate glucose and insulin during the 7 hr of observation (n = 9). Based on these results, we suggest that fasting hyperglucagonemia and impaired suppression of glucagon secretion and FFA in response to an oral glucose load may contribute to insulin resistance and glucose intolerance in the SHROB model of metabolic Syndrome X.

PPAR-alpha activator (fenofibrate) restores endothelium responses in spontaneous hypertensive rat

2000 ◽  
Vol 151 (1) ◽  
pp. 213
Author(s):  
O. Jaboureck ◽  
I. Six ◽  
D. Deplancke ◽  
A. Caillez ◽  
J.C. Fruchart ◽  
...  
Keyword(s):  
Ppar Alpha ◽  
Spontaneous Hypertensive Rat ◽  
Hypertensive Rat

Renoprotective Differences between Perindopril and Enalapril in the Diabetic Hypertensive Rat Do Not Reflect Glomerular Angiotensin-Converting Enzyme Activity

1998 ◽  
Vol 94 (5) ◽  
pp. 511-516 ◽  
Author(s):  
K. A. Duggan ◽  
G. Hodge ◽  
M. M. Makarious ◽  
J. A. Charlesworth
Keyword(s):  
Enzyme Activity ◽  
Angiotensin Converting Enzyme ◽  
Protein Content ◽  
Protein Accumulation ◽  
Converting Enzyme ◽  
Angiotensin Converting Enzyme Activity ◽  
Spontaneous Hypertensive Rat ◽  
Hypertensive Rat ◽  
Plasma Angiotensin ◽  
Plasma Angiotensin Converting Enzyme

1. The various angiotensin-converting enzyme inhibitors have structural differences which affect their affinities for the catalytic sites on converting enzyme. We postulated that such differences might result in differences in renoprotective efficacy. We investigated this in the diabetic spontaneous hypertensive rat. We also investigated whether these differences might reflect variations in glomerular or plasma angiotensin-converting enzyme activity. 2. One week after induction of diabetes, rats were started on antihypertensive therapy: enalapril, 10 mg · day−1 · kg−1, or perindopril, 4 mg · day−1 · kg−1, in the drinking water. After 3 months, the rats were killed, blood samples were taken and tissues were harvested. Angiotensin-converting enzyme activity in isolated glomeruli and plasma was measured by fluorimetric assay. Glomerular protein content was also determined. 3. Urinary protein excretion was significantly lower in perindopril-treated rats than in either controls (P < 0.0005) or enalapril-treated rats P < 0.05). Glomerular protein content was also lower in perindopril-treated rats (P < 0.05 versus enalapril; P < 0.005 versus control). There was no difference in glomerular angiotensin-converting enzyme activity between the two inhibitors although both were lower than control values (enalapril P < 0.025; perindopril P < 0.025). Plasma angiotensin-converting enzyme activity was significantly lower in the perindopril group than in either control (P < 0.005) or the enalapril group (P < 0.01). 4. We conclude that in the spontaneous hypertensive rat with streptozotocin-induced diabetes, perindopril is more effective than enalapril in reducing proteinuria and glomerular protein accumulation. This difference does not result from differences in glomerular-converting enzyme activity.

scholarly journals The lung beta-receptor in the spontaneous hypertensive rat.

1984 ◽  
Vol 48 (11) ◽  
pp. 1203-1209 ◽  
Author(s):  
FUMITAKA OHSUZU ◽  
H. WILLIAM STRAUSS ◽  
CHARLES J. HOMCY
Keyword(s):  
Beta Receptor ◽  
Spontaneous Hypertensive Rat ◽  
Hypertensive Rat

Expression of DNA synthetic phase(S-phase) in the cardiomegaly of the spontaneous hypertensive rat(SHR)

1990 ◽  
Vol 22 ◽  
pp. S101
Author(s):  
H. Tachibana ◽  
S. Inoue ◽  
T. Sakai ◽  
T. Saito ◽  
T. Katagiri ◽  
...  
Keyword(s):  
S Phase ◽  
Spontaneous Hypertensive Rat ◽  
Hypertensive Rat ◽  
Synthetic Phase
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