scholarly journals Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure

2020 ◽  
Vol 7 (3) ◽  
pp. 1101-1108
Author(s):  
Marcelo Rodrigues Dos Santos ◽  
Guilherme Wesley Peixoto Fonseca ◽  
Letícia Pironato Sherveninas ◽  
Francis Ribeiro Souza ◽  
Antônio Carlos Battaglia Filho ◽  
...  
Keyword(s):  
Heart Failure ◽  
Functional Capacity ◽  
Patients With Heart Failure ◽  
Gynoid Fat ◽  
Male Patients

P4539Android to gynoid fat ratio and its association with functional capacity in male patients with heart failure

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
M R Dos Santos ◽  
G W P Fonseca ◽  
L Sherveninas ◽  
F R Souza ◽  
A C Battaglia Filho ◽  
...  
Keyword(s):  
Heart Failure ◽  
Functional Capacity ◽  
Fat Distribution ◽  
Exercise Intolerance ◽  
Sarcopenic Obesity ◽  
Peak Vo2 ◽  
Patients With Heart Failure ◽  
Gynoid Fat ◽  
Male Patients ◽  
G Ratio

Abstract Background Obesity may have a protective role in patients with heart failure with reduced ejection fraction (HFrEF), a phenomenon known as obesity paradox. However, some patients can also present sarcopenic obesity with similar exercise intolerance as lean patients with muscle wasting. However, the impact of body fat distribution on exercise intolerance in HFrEF is unknown. Purpose To study the association between android to gynoid fat ratio and functional capacity (VO2 peak) in male patients with HFrEF. Methods We enrolled 118 male with HFrEF with left ventricular ejection fraction (LVEF) <40%, mean age of 56±7 years old. Body composition was measured with dual x-ray absorptiometry. Android and gynoid fat were measured and the ratio between them was calculated (A/G ratio). Appendicular lean mass (ALM) was calculated as the lean muscle mass of both arms and legs divided by the height squared. Sarcopenic obesity was defined according to Foundation for the National Institutes of Health criteria (ALM adjusted for body mass index <0.789 for men). Muscle strength was assessed using the handgrip dynamometer (cutoff point for sarcopenia was defined as proposed by European Working Group on Sarcopenia in Older People). Blood sample was used to measure metabolic and hormonal parameters. Results Of those 118 patients, 15 (12.7%) showed sarcopenic obesity. In our cohort, the median A/G ratio was 0.55. A/G ratio >0.55 was detected in 60 patients. Weight and BMI were higher in patients with A/G ratio >0.55 (P<0.001). Absolute peak VO2 was similar between patients with A/G ratio lower or higher than 0.55 (1.48±0.40 vs. 1.43±0.40 L/min, P=0.559), while relative peak VO2 was lower in patients with A/G ratio >0.55 (18.7±5.3 vs. 22.5±6.1 mL/kg/min, P<0.001). LVEF, total cholesterol, LDL, haemoglobin, and IGF-1 were similar between patients with A/G ratio lower or higher than 0.55 (P>0.05). On the other hand, HDL, total testosterone, free testosterone, and DHEA were lower in patients with A/G ratio >0.55 (P<0.05). Logistic regression analysis showed A/G Ratio >0.55 to be independently associated with reduced peak VO2 (L/min) adjusted for age, BMI, LVEF, presence of sarcopenia, anabolic hormones, and haemoglobin (odds ratio 3.895, 95% CI 1.030–14.730, p=0.045). Conclusion Our data suggest that body fat distribution, particularly android and gynoid fat composition, might have an important adverse role on functional capacity in male patients with HFrEF. Acknowledgement/Funding FAPESP #2016/24306-0 and 2016/24833-0

Soothing the sleeping giant: improving skeletal muscle oxygen kinetics and exercise intolerance in HFpEF

2015 ◽  
Vol 119 (6) ◽  
pp. 734-738 ◽  
Author(s):  
Satyam Sarma ◽  
Benjamin D. Levine
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Oxygen Consumption ◽  
Functional Capacity ◽  
Oxidative Capacity ◽  
Exercise Intolerance ◽  
Aerobic Performance ◽  
Muscle Oxygen ◽  
Oxygen Kinetics ◽  
Patients With Heart Failure

Patients with heart failure with preserved ejection fraction (HFpEF) have similar degrees of exercise intolerance and dyspnea as patients with heart failure with reduced EF (HFrEF). The underlying pathophysiology leading to impaired exertional ability in the HFpEF syndrome is not completely understood, and a growing body of evidence suggests “peripheral,” i.e., noncardiac, factors may play an important role. Changes in skeletal muscle function (decreased muscle mass, capillary density, mitochondrial volume, and phosphorylative capacity) are common findings in HFrEF. While cardiac failure and decreased cardiac reserve account for a large proportion of the decline in oxygen consumption in HFrEF, impaired oxygen diffusion and decreased skeletal muscle oxidative capacity can also hinder aerobic performance, functional capacity and oxygen consumption (V̇o2) kinetics. The impact of skeletal muscle dysfunction and abnormal oxidative capacity may be even more pronounced in HFpEF, a disease predominantly affecting the elderly and women, two demographic groups with a high prevalence of sarcopenia. In this review, we 1) describe the basic concepts of skeletal muscle oxygen kinetics and 2) evaluate evidence suggesting limitations in aerobic performance and functional capacity in HFpEF subjects may, in part, be due to alterations in skeletal muscle oxygen delivery and utilization. Improving oxygen kinetics with specific training regimens may improve exercise efficiency and reduce the tremendous burden imposed by skeletal muscle upon the cardiovascular system.

scholarly journals Neuro-hormonal activation predicts ventilatory response to exercise and functional capacity in patients with heart failure

2005 ◽  
Vol 8 (1) ◽  
pp. 46-53 ◽  
Author(s):  
Claudio Passino ◽  
Roberta Poletti ◽  
Francesca Bramanti ◽  
Concetta Prontera ◽  
Aldo Clerico ◽  
...  
Keyword(s):  
Heart Failure ◽  
Functional Capacity ◽  
Ventilatory Response ◽  
Patients With Heart Failure ◽  
Hormonal Activation ◽  
Response To Exercise

Inflammatory biomarkers and effect of exercise on functional capacity in patients with heart failure: Insights from a randomized clinical trial

2017 ◽  
Vol 24 (8) ◽  
pp. 808-817 ◽  
Author(s):  
Miguel M Fernandes-Silva ◽  
Guilherme V Guimarães ◽  
Vagner OC Rigaud ◽  
Marco S Lofrano-Alves ◽  
Rafael E Castro ◽  
...  
Keyword(s):  
Heart Failure ◽  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Functional Capacity ◽  
Inflammatory Biomarkers ◽  
Patients With Heart Failure

scholarly journals Limited value of anaerobic threshold for assessing functional capacity in patients with heart failure

1993 ◽  
Vol 16 (2) ◽  
pp. 133-137 ◽  
Author(s):  
Kyoko Miyagi ◽  
Hidetsugu Asanoi ◽  
Shinji Ishizaka ◽  
Tomoki Kameyama ◽  
Shigetake Sasayama
Keyword(s):  
Heart Failure ◽  
Anaerobic Threshold ◽  
Functional Capacity ◽  
Patients With Heart Failure
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