scholarly journals Haemodynamic effects and potential clinical implications of inhaled nitric oxide during right heart catheterization in heart transplant candidates

2020 ◽  
Vol 7 (2) ◽  
pp. 673-681
Author(s):  
Christopher Strong ◽  
Luís Raposo ◽  
Mariana Castro ◽  
Sérgio Madeira ◽  
António Tralhão ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Heart Transplant ◽  
Right Heart Catheterization ◽  
Haemodynamic Effects ◽  
Inhaled Nitric Oxide ◽  
Heart Catheterization ◽  
Clinical Implications ◽  
Right Heart ◽  
Transplant Candidates

Comparison of Inhaled Nitric Oxide and Inhaled Aerosolized Prostacyclin in the Evaluation of Heart Transplant Candidates With Elevated Pulmonary Vascular Resistance

CHEST Journal ◽  
1998 ◽  
Vol 114 (3) ◽  
pp. 780-786 ◽  
Author(s):  
Åsa Haraldsson ◽  
Niels Kieler-Jensen ◽  
Ulla Nathorst-Westfelt ◽  
Claes-Håkan Bergh ◽  
Sven-Erik Ricksten
Keyword(s):  
Nitric Oxide ◽  
Pulmonary Vascular Resistance ◽  
Vascular Resistance ◽  
Heart Transplant ◽  
Inhaled Nitric Oxide ◽  
Transplant Candidates

Abstract 15302: Cardiac MRI Assessment of Cardiac Output Agrees With Simultaneous Fick Assessment in Pediatric Heart Transplant Patients

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Jennifer Schramm ◽  
Ileen Cronin ◽  
Robert McCarter ◽  
Russell Cross ◽  
joshua kanter ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Heart Transplant ◽  
Phase Contrast ◽  
Right Heart Catheterization ◽  
Heart Catheterization ◽  
Limits Of Agreement ◽  
Right Heart ◽  
Transplant Patients ◽  
Pediatric Heart Transplant ◽  
Good Agreement

Introduction: Systemic cardiac output (Qs) and pulmonary blood flow (Qp) can be measured by cardiac magnetic resonance (CMR) and invasive oximetry, with studies showing good agreement between the two modalities. CMR-guided right heart catheterization (MR-RHC) collects simultaneous CMR and oximetry measurements permitting direct comparison. This study assessed agreement between CMR and Fick measurements of cardiac output in the pediatric heart transplant (HT) population. Methods: Twenty-three pediatric HT patients (body surface area range 0.6-2 m 2 ) with 53 MR-RHC between 2014 -2020 were reviewed. One outlier was excluded due to erroneous pulmonary vein saturation, leaving 52 MR-RHC for analysis. Measurements of un-indexed Qs and Qp from both CMR phase contrast and invasive oximetry using Fick were collected. Bland-Altman (BA) statistical and graphical analyses compared CMR versus Fick estimates of Qs and Qp. Results: BA limits of agreement (LOA) and corresponding concordance plot demonstrate good agreement between CMR and Fick (Figure 1). Panels A and B are the BA and concordance plots for Qs, respectively. Panels C and D are the BA and concordance plots for Qp, respectively. The 95% confidence interval LOA are -1.0 to +1.8 for Qs and -1.0 to +1.7 for Qp. Average bias and Lin correlation are similar for Qs and Qp at +0.36 L/min and 0.8, respectively. Conclusions: CMR and Fick measurements of Qs and Qp are similar in pediatric HT patients, with a tendency for slightly higher values by Fick estimates and similar LOA to previously published results. CMR acquired hemodynamics offer a radiation-free modality to reduce overall radiation exposure for pediatric HT patients.

The Role of Serial Right Heart Catheterization Survey in Patients Awaiting Heart Transplant on Ventricular Assist Device

ASAIO Journal ◽  
2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Diana T. Ruan ◽  
Maryjane Farr ◽  
Yuming Ning ◽  
Paul Kurlansky ◽  
Gabriel Sayer ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Ventricular Assist Device ◽  
Right Heart Catheterization ◽  
Heart Catheterization ◽  
Right Heart ◽  
Assist Device ◽  
Ventricular Assist

scholarly journals P354 Right heart catheterization parameters, echocardiography parameters and B-Type natriuretic peptide prediction of acute cellular rejection in the first year after heart transplant

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
A A Valentim Goncalves ◽  
T Pereira-Da-Silva ◽  
R Soares ◽  
R Ilhao Moreira ◽  
L De Sousa ◽  
...  
Keyword(s):  
Natriuretic Peptide ◽  
Heart Transplant ◽  
Right Heart Catheterization ◽  
Acute Cellular Rejection ◽  
Atrial Pressure ◽  
Right Atrial ◽  
Heart Catheterization ◽  
First Year ◽  
Right Heart ◽  
Cellular Rejection

Abstract Introduction Since the mid-1970s, the diagnosis of acute cellular rejection (ACR) has been made by endomyocardial biopsy (EMB). Whether B-Type Natriuretic Peptide (BNP), transthoracic echocardiography (TTE) parameters and right heart catheterization (RHC) parameters can detect rejection in heart transplant (HT) patients have yielded conflicting results and did not overcome the use of EMB in the first year after HT. Purpose The aim of this study was to evaluate whether BNP, TTE and RHC parameters can be used to detect ACR in the first year after HT. Methods Prospective study of consecutive EMB performed in the first year after HT. Plasma BNP levels, TTE and RHC were performed at the same day. Clinical significant ACR was defined as ≥ 2R, according to the ISHLT 2004 grading. The area under the curve (AUC) was analysed for statistically significant associations to detect ACR. Results From 2017 to 2018, 50 EMB were performed with the following results: 2R - 5 (10.0%); 1R- 29 (58.0%); 0 – 16 (32%). Mean age was 48.7 ± 8.3 years, with mean BNP value of 964.4 ± 1114.7pg/ml. AUC results of BNP and several TTE and RHC parameters for the prediction of ACR are represented in the table. Right atrial pressure (RAP) value (p = 0.027) was the only significantly predictor of ACR, while isovolumic relaxation time measured by TTE revealed a borderline significant trend (p = 0.076). RAP > 10mmHg had a sensitivity of 60.0% and a specificity of 84.4% for detecting ACR. Conclusion Detecting ACR without EMB remains a clinical challenge, but RAP measured by RHC was a significant predictor of ACR in the first year after HT, while BNP values did not correlate with ACR. AUC values PARAMETERS AUC p 95% CI BNP 0.658 0.251 0.405-0.911 Troponin I 0.591 0.507 0.260-0.923 Left ventricular ejection fraction 0.416 0.541 0.218-0.614 E/A 0.480 0.895 0.282-0.678 Deceleration time 0.463 0.463 0.161-0.765 Isovolumic relaxion time 0.745 0.076 0.427-1.000 Cardiac index 0.595 0.488 0.346-0.845 Pulmonary capillary wedge pressure 0.628 0.401 0.329-0.926 Mean pulmonary artery pressure 0.684 0.181 0.511-0.857 Right atrial pressure 0.804 0.027 0.631-0.978 AUC values

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