scholarly journals Characteristics and outcomes of transitions among heart failure categories: a prospective observational cohort study

2020 ◽  
Vol 7 (2) ◽  
pp. 616-625 ◽  
Author(s):  
Jun Gu ◽  
Zhao‐fang Yin ◽  
Hui‐li Zhang ◽  
Yu‐qi Fan ◽  
Jun‐feng Zhang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cohort Study ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Observational Cohort

scholarly journals Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study

The Lancet ◽  
2019 ◽  
Vol 394 (10205) ◽  
pp. 1254-1263 ◽  
Author(s):  
Bernadet T Santema ◽  
Wouter Ouwerkerk ◽  
Jasper Tromp ◽  
Iziah E Sama ◽  
Alice Ravera ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cohort Study ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Observational Cohort

scholarly journals Prevalence and Prognostic Significance of Frailty in Gerontal Inpatients With Pre-clinical Heart Failure: A Subgroup Analysis of a Prospective Observational Cohort Study in China

2020 ◽  
Vol 7 ◽  
Author(s):  
Pei-Pei Zheng ◽  
Si-Min Yao ◽  
Jing Shi ◽  
Yu-Hao Wan ◽  
Di Guo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cohort Study ◽  
Subgroup Analysis ◽  
Frailty Index ◽  
Observational Cohort Study ◽  
Prospective Observational Cohort Study ◽  
Frailty Phenotype ◽  
Observational Cohort ◽  
Clinical Heart Failure

Objective: To evaluate the prognostic value of frailty in gerontal pre-clinical heart failure (stage B heart failure, SBHF) inpatients.Background: The association between frailty and SBHF remains unknown.Methods: We conducted a subgroup analysis of a prospective observational cohort study on frailty. The previous study recruited 1,000 elderly inpatients who were consecutively admitted to a tertiary referral hospital in Beijing, China, from September 2018 to February 2019. The outcomes were all-cause death or readmission at 1-year follow-up. SBHF was diagnosed for asymptomatic cardiac structural or functional abnormalities. Frailty was assessed using the Comprehensive Geriatric Assessment-Frailty Index (CGA-FI).Results: Overall, 531 inpatients aged ≥65 years were deemed to have SBHF and followed up for 1 year. Of them, 34.5% exhibited frailty. During the follow-up period, all-cause death or readmission occurred in 157 (29.5%) participants. Of these participants, 36.6% (67/183) and 25.9% (90/348) belonged to the frail and non-frail groups, respectively (χ2 = 6.655, P = 0.010). Frailty, defined by the CGA-FI, rather than Fried frailty phenotype, could independently predict 1-year all-cause death or readmission (hazard ratio, 1.56; 95% confidence interval, 1.03–2.35; P = 0.034) and was more suitable for predicting all-cause death or readmission than N-terminal pro-B-type natriuretic peptide in female SBHF inpatients aged 80 years or over(AUCCGA−FI vs. AUCNT−proBNP 0.654 vs. 0.575, P = 0.017).Conclusions: Frailty is highly prevalent even among SBHF inpatients aged ≥65 years. The CGA-FI can independently predict 1-year all-cause death or readmission, rather than Fried frailty phenotype. Frailty in gerontal SBHF inpatients deserves more attention.Clinical Trial registration: ChiCTR1800017204; date of registration: 07/18/2018.

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