scholarly journals Sex disparities in acute kidney injury complicating acute myocardial infarction with cardiogenic shock

2019 ◽  
Vol 6 (4) ◽  
pp. 874-877 ◽  
Author(s):  
Saraschandra Vallabhajosyula ◽  
Lina Ya'Qoub ◽  
Shannon M. Dunlay ◽  
Saarwaani Vallabhajosyula ◽  
Shashaank Vallabhajosyula ◽  
...  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Side Gao ◽  
Qingbo Liu ◽  
Hui Chen ◽  
Mengyue Yu ◽  
Hongwei Li

Abstract Background Acute hyperglycemia has been recognized as a robust predictor for occurrence of acute kidney injury (AKI) in nondiabetic patients with acute myocardial infarction (AMI), however, its discriminatory ability for AKI is unclear in diabetic patients after an AMI. Here, we investigated whether stress hyperglycemia ratio (SHR), a novel index with the combined evaluation of acute and chronic glycemic levels, may have a better predictive value of AKI as compared with admission glycemia alone in diabetic patients following AMI. Methods SHR was calculated with admission blood glucose (ABG) divided by the glycated hemoglobin-derived estimated average glucose. A total of 1215 diabetic patients with AMI were enrolled and divided according to SHR tertiles. Baseline characteristics and outcomes were compared. The primary endpoint was AKI and secondary endpoints included all-cause death and cardiogenic shock during hospitalization. The logistic regression analysis was performed to identify potential risk factors. Accuracy was defined with area under the curve (AUC) by a receiver-operating characteristic (ROC) curve analysis. Results In AMI patients with diabetes, the incidence of AKI (4.4%, 7.8%, 13.0%; p < 0.001), all-cause death (2.7%, 3.6%, 6.4%; p = 0.027) and cardiogenic shock (4.9%, 7.6%, 11.6%; p = 0.002) all increased with the rising tertile levels of SHR. After multivariate adjustment, elevated SHR was significantly associated with an increased risk of AKI (odds ratio 3.18, 95% confidence interval: 1.99–5.09, p < 0.001) while ABG was no longer a risk factor of AKI. The SHR was also strongly related to the AKI risk in subgroups of patients. At ROC analysis, SHR accurately predicted AKI in overall (AUC 0.64) and a risk model consisted of SHR, left ventricular ejection fraction, N-terminal B-type natriuretic peptide, and estimated glomerular filtration rate (eGFR) yielded a superior predictive value (AUC 0.83) for AKI. Conclusion The novel index SHR is a better predictor of AKI and in-hospital mortality and morbidity than admission glycemia in AMI patients with diabetes.


PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222894 ◽  
Author(s):  
Saraschandra Vallabhajosyula ◽  
Shannon M. Dunlay ◽  
Gregory W. Barsness ◽  
Saarwaani Vallabhajosyula ◽  
Shashaank Vallabhajosyula ◽  
...  

2010 ◽  
Vol 38 (2) ◽  
pp. 438-444 ◽  
Author(s):  
Giancarlo Marenzi ◽  
Emilio Assanelli ◽  
Jeness Campodonico ◽  
Monica De Metrio ◽  
Gianfranco Lauri ◽  
...  

2021 ◽  
Vol 35 ◽  
pp. 100826
Author(s):  
Ryota Kosaki ◽  
Kohei Wakabayashi ◽  
Shunya Sato ◽  
Hideaki Tanaka ◽  
Kunihiro Ogura ◽  
...  

Author(s):  
Monika Durak ◽  
Marek Tomala ◽  
Bartłomiej Nawrotek ◽  
Andrzej Machnik ◽  
Jacek Legutko

We report a patient with cardiogenic shock (CS) in the course of acute right ventricular myocardial infarction (MI). Our case highlights the use of continuous veno-venous hemofiltration as a novel treatment option for acute kidney injury in the setting of CS and the use of rotational_atherectomy in patients with MI.


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