Portable Microfluidic System for Rapid Genetic Testing

2015 ◽  
Vol 98 (12) ◽  
pp. 1-6 ◽  
Author(s):  
HIDENORI NAGAI ◽  
YUSUKE FUCHIWAKI
Keyword(s):  
Genetic Testing ◽  
Microfluidic System ◽  
Rapid Genetic Testing

iso-μmGene: an isothermal amplification-based portable microfluidic system for simple, reliable and flexibly multiplexed genetic identification and quantification

The Analyst ◽  
2020 ◽  
Vol 145 (13) ◽  
pp. 4627-4636
Author(s):  
Runtao Zhong ◽  
Shilin Liu ◽  
Guohao Zhang ◽  
Mengyu Wang ◽  
Yeqing Sun
Keyword(s):  
Genetic Testing ◽  
Point Of Care ◽  
Microfluidic System ◽  
Isothermal Amplification ◽  
Genetic Identification ◽  
Lamp System ◽  
Identification And Quantification

We present a portable microfluidic LAMP system (iso-μmGene) with features of multi-well chips for convenient filling and reliable sealing, flexible detection throughput, and stand-alone and well-performing point of care device for genetic testing.

Outcomes associated with rapid genetic testing for BRCA1 and BRCA2 at time of breast cancer diagnosis.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 1577-1577
Author(s):  
Kelly A. Metcalfe ◽  
Aletta Poll ◽  
Andrea Eisen ◽  
Jordan Lerner-Ellis ◽  
Steven Narod
Keyword(s):  
Breast Cancer ◽  
Decision Making ◽  
Genetic Testing ◽  
Cancer Diagnosis ◽  
Psychosocial Functioning ◽  
Genetic Test ◽  
Brca Mutation ◽  
Breast Cancer Diagnosis ◽  
Bilateral Mastectomy ◽  
Rapid Genetic Testing

1577 Background: Bilateral mastectomy improves survival for women with BRCA-associated breast cancer. Most women do not know their BRCA status at the time of BC diagnosis when making surgical decisions. Rapid genetic testing (RGT) allows a woman to have genetic test results prior to treatment decision making, but it is unclear if RGT has an impact on treatment choices. It is also unclear if there are psychosocial implications associated with genetic testing at the time of breast cancer diagnosis. The objective of the current study was to assess the impact of RGT at the time of BC diagnosis on surgical decision-making and psychosocial functioning. Methods: Eligible women were referred from participating surgeons at BC diagnosis. Women completed baseline questionnaires assessing treatment preferences, cancer related distress, anxiety, and depression. All participants received in-person pre-test genetic counselling and genetic test results were given within 10 days. Participants completed surveys at 1 week and 1 year post-genetic testing to assess treatments and psychosocial functioning. Results: 1010 women consented to participate and 60 (5.9%) were identified with a BRCA mutation. 15% of those identified with a BRCA mutation did not meet provincial eligibility criteria for genetic testing, and 20% were eligible prior to a breast cancer diagnosis but had not received testing. Mean levels of cancer-related distress, anxiety and depression declined significantly from baseline to 1 year for all women (all p < .05), and there were no differences at any time point between those with and without a BRCA mutation. Of those identified with a BRCA mutation, 67.3% reported that their surgery choice changed. 73.7% of BRCA carriers had a bilateral mastectomy, compared to 20.2% of BRCA negative (p < 0.001). Most women used genetic testing results for surgical decision making (96.1% of BRCA positive and 86.4% for negative). Conclusions: Rapid genetic testing for BRCA1 and BRCA2 at the time of BC diagnosis does not have a negative impact on psychosocial functioning. There are no differences in cancer-related distress, anxiety or depression between women who receive a positive result compare to a negative genetic test result. Furthermore, surgical choice changed for many women identified with a BRCA mutation, with the majority electing for bilateral mastectomy.

Potential benefits of rapid genetic testing for germline WT1 in infants with bilateral renal tumors: A case report

2021 ◽  
Author(s):  
Haruna Yoshikawa ◽  
Takeshi Sato ◽  
Takahiro Ishikawa ◽  
Jumpei Ito ◽  
Fumito Yamazaki ◽  
...  
Keyword(s):  
Case Report ◽  
Genetic Testing ◽  
Renal Tumors ◽  
Potential Benefits ◽  
Rapid Genetic Testing

scholarly journals Clinical Usefulness of Multiplex PCR Lateral Flow in MRSA Detection: A Novel, Rapid Genetic Testing Method

Inflammation ◽  
2011 ◽  
Vol 35 (3) ◽  
pp. 927-934 ◽  
Author(s):  
Shin Nihonyanagi ◽  
Yuhsaku Kanoh ◽  
Kiyomi Okada ◽  
Toshiki Uozumi ◽  
Yukumasa Kazuyama ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Multiplex Pcr ◽  
Lateral Flow ◽  
Clinical Usefulness ◽  
Testing Method ◽  
Rapid Genetic Testing

scholarly journals Rapid genetic testing facilitating the diagnosis of short QT syndrome

2009 ◽  
Vol 25 (4) ◽  
pp. e133-e135 ◽  
Author(s):  
Calum J. Redpath ◽  
Martin S. Green ◽  
David H. Birnie ◽  
Michael H. Gollob
Keyword(s):  
Genetic Testing ◽  
Short Qt Syndrome ◽  
Qt Syndrome ◽  
Rapid Genetic Testing

Simple and rapid genetic testing for citrin deficiency by screening 11 prevalent mutations in SLC25A13

2012 ◽  
Vol 105 (4) ◽  
pp. 553-558 ◽  
Author(s):  
Atsuo Kikuchi ◽  
Natsuko Arai-Ichinoi ◽  
Osamu Sakamoto ◽  
Yoichi Matsubara ◽  
Takeyori Saheki ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Citrin Deficiency ◽  
Rapid Genetic Testing
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