scholarly journals Physiological adaptations to sugar‐mimic alkaloids: Insights from Bombyx mori for long‐term adaption and short‐term response

2020 ◽  
Vol 10 (18) ◽  
pp. 9682-9695
Author(s):  
Shunze Jia ◽  
Yinghui Li ◽  
Xiangping Dai ◽  
Xiaotong Li ◽  
Yanyan Zhou ◽  
...  
Keyword(s):  
Bombyx Mori ◽  
Short Term ◽  
Physiological Adaptations ◽  
Term Response

Unfolding the case of returnees: How the European Union and its member States are addressing the return of foreign fighters and their families

2021 ◽  
pp. 1-23
Author(s):  
Carlota Rigotti ◽  
Júlia Zomignani Barboza
Keyword(s):  
European Union ◽  
Perceived Threat ◽  
The European Union ◽  
Security Threat ◽  
Short Term ◽  
Member States ◽  
Foreign Fighters ◽  
Term Response

Abstract The return of foreign fighters and their families to the European Union has mostly been considered a security threat by member States, which consequently adopt repressive measures aimed at providing an immediate, short-term response to this perceived threat. In addition to this strong-arm approach, reintegration strategies have also been used to prevent returnees from falling back into terrorism and to break down barriers of hostility between citizens in the long term. Amidst these different strategies, this paper seeks to identify which methods are most desirable for handling returnees.

An oncology clinical trial design with randomization adaptive to both short- and long-term responses

2017 ◽  
Vol 28 (7) ◽  
pp. 2015-2031 ◽  
Author(s):  
Hao Liu ◽  
Xiao Lin ◽  
Xuelin Huang
Keyword(s):  
Trial Design ◽  
Clinical Trial Design ◽  
Therapeutic Benefit ◽  
Survival Outcome ◽  
Operating Characteristics ◽  
Short Term ◽  
Term Survival ◽  
Long Term Survival ◽  
Term Response

In oncology clinical trials, both short-term response and long-term survival are important. We propose an urn-based adaptive randomization design to incorporate both of these two outcomes. While short-term response can update the randomization probability quickly to benefit the trial participants, long-term survival outcome can also change the randomization to favor the treatment arm with definitive therapeutic benefit. Using generalized Friedman’s urn, we derive an explicit formula for the limiting distribution of the number of subjects assigned to each arm. With prior or hypothetical knowledge on treatment effects, this formula can be used to guide the selection of parameters for the proposed design to achieve desirable patient number ratios between different treatment arms, and thus optimize the operating characteristics of the trial design. Simulation studies show that the proposed design successfully assign more patients to the treatment arms with either better short-term tumor response or long-term survival outcome or both.

Short-term response in new users of anti-TNF predicts long-term productivity and non-disability: analysis of Czech ATTRA ankylosing spondylitis biologic registry

2019 ◽  
Vol 20 (2) ◽  
pp. 183-192
Author(s):  
Jan Tužil ◽  
Tomáš Mlčoch ◽  
Jitka Jirčíková ◽  
Jakub Závada ◽  
Lucie Nekvindová ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Short Term ◽  
Term Response

Aristotle's Manipulative Maxims

2020 ◽  
Vol 82 (3) ◽  
pp. 371-392
Author(s):  
Daniel DiLeo
Keyword(s):  
Political Knowledge ◽  
Short Term ◽  
Human Good ◽  
Political Problem ◽  
Term Response

AbstractIn actual regimes as described by Aristotle, authoritative civic choices were not the outcome of speech among citizens about the noble things and the just things. Rather, he saw them as products of the flawed presuppositions and misperceptions of dominant factions. Since he held that the human good was dependent on the persistence of lawful systems of rule, no matter how flawed, he viewed the tendency of dominant factions toward regime-destructive extremism as the fundamental political problem. His short-term response was to teach manipulative rhetoric and the outline of a strategy for regime preservation to his students. This equipped his students to prevail against the speech of the ignorant and malevolent and impressed those students with the need to acquire political knowledge. His long-term response was the initiation of a system of education that would turn citizens away from regime-destructive predilections.

Thermal acclimation of respiration but not photosynthesis in Pinus radiata

2008 ◽  
Vol 35 (6) ◽  
pp. 448 ◽  
Author(s):  
Lai Fern Ow ◽  
David Whitehead ◽  
Adrian S. Walcroft ◽  
Matthew H. Turnbull
Keyword(s):  
Pinus Radiata ◽  
Growth Temperature ◽  
Dark Respiration ◽  
Temperature Acclimation ◽  
Short Term ◽  
Photosynthesis And Respiration ◽  
Term Response ◽  
N Status ◽  
Respiratory Responses

Pinus radiata L. were grown in climate-controlled cabinets under three night/day temperature treatments, and transferred between treatments to mimic changes in growth temperature. The objective was to determine the extent to which dark respiration and photosynthesis in pre-existing and new needles acclimate to changes in growth temperatures. We also assessed whether needle nitrogen influenced the potential for photosynthetic and respiratory acclimation, and further assessed if short-term (instantaneous, measured over a few hours) respiratory responses are accurate predictors of long-term (acclimated, achieved in days–weeks) responses of respiration to changing temperature. Results show that respiration displayed considerable potential for acclimation. Cold and warm transfers resulted in some acclimation of respiration in pre-existing needles, but full acclimation was displayed only in new needles formed at the new growth temperature. Short-term respiratory responses were poor predictors of the long-term response of respiration due to acclimation. There was no evidence that photosynthesis in pre-existing or new needles acclimated to changes in growth temperature. N status of leaves had little impact on the extent of acclimation. Collectively, our results indicate that there is little likelihood that respiration would be significantly stimulated in this species as night temperatures increase over the range of 10–20°C, but that inclusion of temperature acclimation of respiration would in fact lead to a shift in the balance between photosynthesis and respiration in favour of carbon uptake.

scholarly journals Refreshing and Removing Items in Working Memory: Different Approaches to Equivalent Processes?

2019 ◽  
Author(s):  
Evan Nathaniel Lintz ◽  
Matthew Johnson
Keyword(s):  
Working Memory ◽  
Lexical Decision ◽  
Response Time ◽  
Fundamental Difference ◽  
Long Term Memory ◽  
Test Results ◽  
Short Term ◽  
Term Memory ◽  
Term Response

Researchers have investigated “refreshing” of items in working memory (WM) as ameans of preserving them, while concurrently, other studies have examined “removal” of items from WM that are irrelevant. However, it is unclear whether refreshing and removal in WM truly represent different processes, or if participants, in an effort to avoid the to-be-removed items, simply refresh alternative items. We conducted two experiments to test whether these putative processes can be distinguished from one another. Participants were presented with sets of three words and then cued to either refresh one item or remove two items from WM, followed by a lexical decision probe containing either one of the just-seen words or a non-word. In Experiment 1, all probes were valid and in Experiment 2, probes were occasionally invalid (the probed word was one of the removed/non-refreshed items). In both experiments, participants also received a subsequent surprise long-term memory test. Results from both experiments suggested the expected advantages for refreshed (or non-removed) items in both short-term response time and long-term recognition, but no differences between refresh and remove instructions that would suggest a fundamental difference in processes. Thus, we argue that a functional distinction between refreshing and removal may not be necessary, and propose that both of these putative processes could potentially be subsumed under an overarching conceptual perspective based on the flexible reallocation of mental or reflective attention.

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