scholarly journals Combining molecular evolution and environmental genomics to unravel adaptive processes of MHC class IIB diversity in European minnows (Phoxinus phoxinus)

2013 ◽  
Vol 3 (8) ◽  
pp. 2568-2585 ◽  
Author(s):  
Helene Collin ◽  
Reto Burri ◽  
Fabien Comtesse ◽  
Luca Fumagalli
Keyword(s):  
Molecular Evolution ◽  
Phoxinus Phoxinus ◽  
Environmental Genomics ◽  
Adaptive Processes ◽  
Mhc Class Iib ◽  
Class Iib

scholarly journals MHC genes and oxidative stress in sticklebacks: an immuno-ecological approach

2006 ◽  
Vol 273 (1592) ◽  
pp. 1407-1414 ◽  
Author(s):  
Joachim Kurtz ◽  
K. Mathias Wegner ◽  
Martin Kalbe ◽  
Thorsten B.H Reusch ◽  
Helmut Schaschl ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Susceptibility To Infection ◽  
Mhc Genes ◽  
Histocompatibility Complex ◽  
Individual Host ◽  
Experimental Approaches ◽  
Mhc Class Iib ◽  
Class Iib ◽  
First Time ◽  
And Oxidative Stress

Individual variation in the susceptibility to infection may result from the varying ability of hosts to specifically recognize different parasite strains. Alternatively, there could be individual host differences in fitness costs of immune defence. Although, these two explanations are not mutually exclusive, they have so far been treated in separate experimental approaches. To analyse potential relationships, we studied body condition and oxidative stress, which may reflect costs of immunity, in three-spined sticklebacks that had been experimentally exposed to three species of naturally occurring parasite. These sticklebacks differed in a trait, which is crucial to specific parasite defence, i.e. individual genetic diversity at major histocompatibility complex (MHC) class IIB loci. Oxidative stress was quantified as tissue acrolein, a technique that has been applied to questions of immuno-ecology for the first time. We measured gene expression at the MHC and other estimates of immune activation. We found that fish with high levels of MHC expression had poor condition and elevated oxidative stress. These results indicate that MHC-based specific immunity is connected with oxidative stress. They could, thus, also be relevant in the broader context of the evolution of sexually selected signals that are based on carotenoids and are, thus supposed to reflect oxidative stress resistance.

SSCP analysis of Mhc class IIB genes in the threespine stickleback

2001 ◽  
Vol 58 (3) ◽  
pp. 887-890 ◽  
Author(s):  
T. Binz ◽  
T. B. H. Reusch ◽  
C. Wedekind ◽  
M. Milinski
Keyword(s):  
Threespine Stickleback ◽  
Sscp Analysis ◽  
Mhc Class Iib ◽  
Class Iib

scholarly journals Selection at the MHC class IIB locus across guppy (Poecilia reticulata) populations

Heredity ◽  
2009 ◽  
Vol 104 (2) ◽  
pp. 155-167 ◽  
Author(s):  
B A Fraser ◽  
I W Ramnarine ◽  
B D Neff
Keyword(s):  
Poecilia Reticulata ◽  
Mhc Class Iib ◽  
Class Iib

MHC class�IIB gene sequences and expression in quails (Coturnix japonica) selected for high and low antibody responses

2004 ◽  
Vol 56 (4) ◽  
Author(s):  
Sayoko Shimizu ◽  
Takashi Shiina ◽  
Kazuyoshi Hosomichi ◽  
Shinji Takahashi ◽  
Takumi Koyama ◽  
...  
Keyword(s):  
Antibody Responses ◽  
Coturnix Japonica ◽  
Gene Sequences ◽  
Mhc Class Iib ◽  
Class Iib

scholarly journals Polymorphism of sheep MHC Class IIb gene TAPASIN

2010 ◽  
Vol 137 (1-2) ◽  
pp. 176-180 ◽  
Author(s):  
N. Siva Subramaniam ◽  
E.F. Morgan ◽  
C.Y. Lee ◽  
J.D. Wetherall ◽  
D.M. Groth
Keyword(s):  
Mhc Class Iib ◽  
Class Iib

scholarly journals Latitudinal MHC variation and haplotype associated differential survival in response to experimental infection of two strains of Batrachochytrium dendrobatitis (Bd-GPL) in common toads

2019 ◽  
Author(s):  
Maria Cortazar-Chinarro ◽  
Sara Meurling ◽  
Laurens Schroyens ◽  
Mattias Siljestam ◽  
Alex Ritcher-Boix ◽  
...  
Keyword(s):  
Adaptive Immune System ◽  
Bufo Bufo ◽  
Chytrid Fungus ◽  
Differential Survival ◽  
Lower Survival ◽  
The North ◽  
Mhc Haplotype ◽  
Mhc Diversity ◽  
Mhc Class Iib ◽  
Class Iib

AbstractWhile both innate and adaptive immune system mechanisms have been implicated in resistance against the chytrid fungus Batrachochytrium dendrobatitis, studies on the role of specific MHC haplotypes on Bd infection are rare. Here, we studied latitudinal variation in MHC Class IIB loci along a latitudinal gradient from southern to northern Sweden in common toads, Bufo bufo. Swedish toad populations had fewer MHC Class IIB haplotypes compared to a previous study of populations in Britain. Furthermore, we found MHC diversity to decline from south to the north within Sweden. The low diversity may compromise the ability of northern populations to fight emerging disease, such as the chytrid fungus Bd. In a laboratory experiment, we infected newly metamorphosed toads with two strains of the Global Pandemic Lineage of the fungus (Bd-GPL) and compared survival with sham controls. We found Bd-infected toads had lower survival compared to controls. Survival was dependent on Bd-strain and whether experimental toads where collected in the south or the north of Sweden with lower survival in northern individuals. MHC diversity was lower in toads of northern origin, all northern animals being monomorphic for a single MHC haplotype, whereas we found seven different haplotypes in southern animals. Survival of infected animals was dependent on both Bd-strain and MHC haplotype suggesting differential infection dynamics depending on both Bd-strain and host MHC characteristics.

Comparative analysis of the bovine MHC class IIb sequence1 identifies inversion breakpoints and three unexpected genes

2006 ◽  
Vol 37 (2) ◽  
pp. 121-129 ◽  
Author(s):  
C. P. Childers ◽  
H. L. Newkirk ◽  
D. A. Honeycutt ◽  
N. Ramlachan ◽  
D. M. Muzney ◽  
...  
Keyword(s):  
Comparative Analysis ◽  
Mhc Class Iib ◽  
Class Iib ◽  
Inversion Breakpoints
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