scholarly journals The draft genome of Actinia tenebrosa reveals insights into toxin evolution

2019 ◽  
Vol 9 (19) ◽  
pp. 11314-11328 ◽  
Author(s):  
Joachim M. Surm ◽  
Zachary K. Stewart ◽  
Alexie Papanicolaou ◽  
Ana Pavasovic ◽  
Peter J. Prentis
Keyword(s):  
Draft Genome ◽  
Toxin Evolution

scholarly journals Toxins from scratch? Diverse, multimodal gene origins in the predatory robber fly Dasypogon diadema indicate a dynamic venom evolution in dipteran insects

GigaScience ◽  
2019 ◽  
Vol 8 (7) ◽  
Author(s):  
Stephan Holger Drukewitz ◽  
Lukas Bokelmann ◽  
Eivind A B Undheim ◽  
Björn M von Reumont
Keyword(s):  
Single Gene ◽  
Draft Genome ◽  
Evolutionary Analysis ◽  
Orphan Genes ◽  
High Quality ◽  
Venom Protein ◽  
Robber Flies ◽  
Venom Evolution ◽  
Toxin Evolution ◽  
Venom Proteins

Abstract Background Venoms and the toxins they contain represent molecular adaptations that have evolved on numerous occasions throughout the animal kingdom. However, the processes that shape venom protein evolution are poorly understood because of the scarcity of whole-genome data available for comparative analyses of venomous species. Results We performed a broad comparative toxicogenomic analysis to gain insight into the genomic mechanisms of venom evolution in robber flies (Asilidae). We first sequenced a high-quality draft genome of the hymenopteran hunting robber fly Dasypogon diadema, analysed its venom by a combined proteotranscriptomic approach, and compared our results with recently described robber fly venoms to assess the general composition and major components of asilid venom. We then applied a comparative genomics approach, based on 1 additional asilid genome, 10 high-quality dipteran genomes, and 2 lepidopteran outgroup genomes, to reveal the evolutionary mechanisms and origins of identified venom proteins in robber flies. Conclusions While homologues were identified for 15 of 30 predominant venom protein in the non-asilid genomes, the remaining 15 highly expressed venom proteins appear to be unique to robber flies. Our results reveal that the venom of D. diadema likely evolves in a multimodal fashion comprising (i) neofunctionalization after gene duplication, (ii) expression-dependent co-option of proteins, and (iii) asilid lineage-specific orphan genes with enigmatic origin. The role of such orphan genes is currently being disputed in evolutionary genomics but has not been discussed in the context of toxin evolution. Our results display an unexpected dynamic venom evolution in asilid insects, which contrasts the findings of the only other insect toxicogenomic evolutionary analysis, in parasitoid wasps (Hymenoptera), where toxin evolution is dominated by single gene co-option. These findings underpin the significance of further genomic studies to cover more neglected lineages of venomous taxa and to understand the importance of orphan genes as possible drivers for venom evolution.

Draft genome of starch-degrading actinobacterium, Microbacterium mangrovi MUSC 115T isolated from intertidal sediments

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Hooi-Leng Ser ◽  
Wen-Si Tan ◽  
Huey-Jia Cheng ◽  
Wai-Fong Yin ◽  
Kok-Gan Chan ◽  
...  
Keyword(s):  
Draft Genome ◽  
Intertidal Sediments ◽  
Total Size ◽  
General Physiology ◽  
Genome Features

Microbacterium mangrovi strain MUSC 115T was isolated from intertidal sediments of Kuantan, Malaysia. Here we describe the draft genome of amylolytic strain MUSC 115T with total size of 4.4 Mbp from 55 contigs and G + C content of 70.0%. Total of 4,096 coding genes were observed, with 2 putative amylases genes in the draft genome of MUSC 115T. These genome features of MUSC 115T can improve our understanding of its starch-degrading mechanism and general physiology of the species, which provide opportunities for biotechnological and industrial exploitation.

scholarly journals Draft Genome Sequence of Trebouxiophyceae sp. Strain KSI-1, Isolated from an Island Hot Spring

2018 ◽  
Vol 7 (16) ◽  
Author(s):  
Hiro Takahashi ◽  
Satoshi Tanaka ◽  
Shuhei Hayashi ◽  
Shido Miyaki ◽  
Anna Takahashi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Green Alga ◽  
Genome Sequence ◽  
Hot Spring ◽  
Draft Genome ◽  
Draft Genome Sequence

Trebouxiophyceae sp. KSI-1 is a green alga isolated from a seashore hot spring on Satsuma Iōjima in Kagoshima, Japan, and is highly tolerant to oxidative stress.

scholarly journals Draft Genome Sequence of Urease-Producing Pseudorhodobacter sp. Strain E13, Isolated from the Yellow Sea in Gunsan, South Korea

2019 ◽  
Vol 8 (23) ◽  
Author(s):  
Si Chul Kim ◽  
Hyo Jung Lee
Keyword(s):  
South Korea ◽  
Genome Sequence ◽  
Yellow Sea ◽  
Draft Genome ◽  
The Yellow Sea ◽  
Draft Genome Sequence ◽  
Protein Coding ◽  
Coding Sequences ◽  
Gram Negative ◽  
Content Type

Here, we report the draft genome sequence of Pseudorhodobacter sp. strain E13, a Gram-negative, aerobic, nonflagellated, and rod-shaped bacterium which was isolated from the Yellow Sea in South Korea. The assembled genome sequence is 3,878,578 bp long with 3,646 protein-coding sequences in 159 contigs.

scholarly journals Draft Genome Sequences of 12 Mycolicibacterium smegmatis Strains Resistant to Imidazo[1,2-b][1,2,4,5]Tetrazines

2019 ◽  
Vol 8 (16) ◽  
Author(s):  
Aleksey A. Vatlin ◽  
Kirill V. Shur ◽  
Valery N. Danilenko ◽  
Dmitry A. Maslov
Keyword(s):  
Draft Genome ◽  
Transcriptional Repressor ◽  
Antituberculosis Drug ◽  
Genome Sequences ◽  
Content Type ◽  
Drug Candidates

Here, we report 12 draft genome sequences of mutant Mycolicibacterium smegmatis strains resistant to imidazo[1,2-b][1,2,4,5]tetrazines, which are antituberculosis drug candidates. We have identified 7 different mutations in the MSMEG_1380 gene, which encodes the AcrR/TetR_N transcriptional repressor, which may activate efflux-mediated resistance.

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