Residential cognitive-behavioral weight-loss intervention for obesity with and without binge-eating disorder: A prospective case-control study with five-year follow-up

2016 ◽  
Vol 49 (7) ◽  
pp. 723-730 ◽  
Author(s):  
Simona Calugi ◽  
Antonella Ruocco ◽  
Marwan El Ghoch ◽  
Coppini Andrea ◽  
Eleonora Geccherle ◽  
...  
Keyword(s):  
Weight Loss ◽  
Eating Disorder ◽  
Case Control Study ◽  
Case Control ◽  
Weight Loss Intervention ◽  
Behavioral Weight Loss ◽  
Behavioral Weight Loss Intervention ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals Autologous adipose-derived stem cells for the treatment of complex cryptoglandular perianal fistula: a prospective case-control study

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yang Zhang ◽  
Min Ni ◽  
Chungen Zhou ◽  
Yehuang Wang ◽  
Yaxian Wang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Adverse Events ◽  
Case Control Study ◽  
Perianal Fistula ◽  
Case Control ◽  
Wexner Score ◽  
Significant Difference ◽  
Control Study ◽  
Prospective Case Control Study

Abstract Background Complex cryptoglandular perianal fistula (CPAF) is a kind of anal fistula that may cause anal incontinence after surgery. Minimally invasive surgery of anal fistula is constantly emerging. Over the past 20 years, there are several sphincter-sparing surgeries, one of which is autologous adipose-derived stem cell (ADSC) transplantation. However, to date, there is no study regarding the treatment of complex CPAF with ADSC in China. This is the first study in China on the treatment of complex CPAF with ADSC to evaluate its safety and efficacy. Methods Totally, 24 patients with complex CPAF were enrolled in this prospective case-control study from January 2018 to December 2019 in the National Colorectal Disease Center of Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine. Patients were divided into ADSC group and endorectal advancement flap (ERAF) group according to their desire. The healing of fistulas (healing of all treated fistulas at baseline, confirmed by doctor’s clinical assessment and magnetic resonance imaging or transrectal ultrasonography) was evaluated at week 12 after treatment. In addition to their safety evaluation based on adverse events monitored at each follow-up, the patients were also asked to complete some scoring scales at each follow-up including pain score with visual analog score (VAS) and anal incontinence score with Wexner score. Results The closure rates within ADSC group and ERAF group at week 12 were 54.55% (6/11) and 53.85% (7/13), respectively, without significant difference between them. VAS score in ADSC group was significantly lower than that in ERAF group at the 5th day postoperatively [1(0,2) VS 2(2,4), p = 0.011], but no differences were observed at the other time. Wexner score of all patients was not increased with no significant differences between the two groups. Adverse events were observed fewer in ADSC group (27.27%) than that in ERAF group (53.85%), but there was no significant difference between them. Conclusion This study indicated safety and efficiency of ADSC for the treatment of complex CPAF in the short term, which is not inferior to that of ERAF. ADSC may provide a promised and potential treatment for complex CPAF conforming to the future of the treatment, which is reconstruction and regeneration. Trail registration ChiCTR, ChiCTR1800014599. Registered 23 January 2018—retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj=24548

scholarly journals Bariatric Surgery for Hypothalamic Obesity in Craniopharyngioma Patients: A Retrospective, Matched Case-Control Study

2021 ◽  
Author(s):  
Selveta S van Santen ◽  
Peter Wolf ◽  
Natalia Kremenevski ◽  
Cesar L Boguszewski ◽  
Hannes Beiglböck ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Case Control Study ◽  
Case Control ◽  
Hypothalamic Obesity ◽  
Control Study

Abstract Context Craniopharyngioma is a sellar tumor associated with high rates of pituitary deficiencies (~98%) and hypothalamic obesity (~50%). Objective To determine the efficacy regarding long-term weight loss after bariatric surgery in obese craniopharyngioma patients with hypothalamic dysfunction. Design Retrospective case control study. Setting Multicenter international study. Patients and participants Obese craniopharyngioma patients (N = 16; of which 12 women) with a history of bariatric surgery [12 Roux-en-Y gastric bypass, 4 sleeve gastrectomy; median age of 21 years (range 15-52), median follow-up 5.2 years (range 2.0-11.3)] and age/sex/surgery/BMI-matched obese controls (N = 155). Main outcome measures Weight loss and obesity-related comorbidities up to 5 years after bariatric surgery were compared and changes in hormonal replacement therapy evaluated. Results Mean weight loss at 5-year follow-up was 22.0% (95% CI 16.1, 27.8) in patients versus 29.5% (28.0, 30.9) in controls (P = 0.02), which was less after Roux-en-Y gastric bypass (22.7% [16.9, 28.5] vs. 32.0% [30.4, 33.6]; P = 0.003) but at a similar level after sleeve gastrectomy (21.7% [–1.8, 45.2] vs. 21.8% [18.2, 25.5]; P = 0.96). No major changes in endocrine replacement therapy were observed after surgery. One patient died (unknown cause). One patient had long-term absorptive problems. Conclusions Obese patients with craniopharyngioma had a substantial mean weight loss of 22% at 5-year follow-up after bariatric surgery, independent of type of bariatric surgery procedure. Weight loss was lower than in obese controls after Roux-en-Y gastric bypass. Bariatric surgery appears effective and relatively safe in the treatment of obese craniopharyngioma patients.

Vitamin D levels in Irish children with fractures: A prospective case–control study with 5 year follow-up

The Surgeon ◽  
2021 ◽  
Author(s):  
Dave M. Moore ◽  
Mike O'Sullivan ◽  
Pat Kiely ◽  
Jacques Noel ◽  
Pat O'Toole ◽  
...  
Keyword(s):  
Vitamin D ◽  
Case Control Study ◽  
Case Control ◽  
Vitamin D Levels ◽  
Control Study ◽  
Prospective Case Control Study

scholarly journals The Impact of COVID-19 Lockdown on Patients with Obesity after Intensive Cognitive Behavioral Therapy—A Case-Control Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2021
Author(s):  
Simona Calugi ◽  
Beatrice Andreoli ◽  
Laura Dametti ◽  
Anna Dalle Grave ◽  
Nicole Morandini ◽  
...  
Keyword(s):  
Weight Loss ◽  
Health Status ◽  
Binge Eating ◽  
General Health ◽  
Case Control Study ◽  
Behavioral Therapy ◽  
Case Control ◽  
General Health Status ◽  
Control Study

Background: The COVID-19 lockdown may have negatively impacted the treatment of obesity. This study aimed to assess the effect of COVID-19 lockdown in patients with obesity treated with intensive residential cognitive behavioral therapy (CBT-OB). Methods: This retrospective case-control study analyzed 129 patients with severe obesity who experienced COVID-19 lockdown in the 6 months after discharge from intensive residential CBT-OB, comparing their outcomes on weight loss, binge-eating episodes, and general health status with those in a sample of patients matched by gender, age, and body mass index given the same treatment before the COVID-19 outbreak as control. Patients were assessed at baseline and by phone interview 6-month follow-up. Results: Both groups had lost more than 9% of their baseline bodyweight and reported a significant decrease in binge-eating episodes and similar general health status at 6-month follow-up. However, control patients achieved a significantly greater weight loss than those who experienced lockdown, although half of lockdown patients reported persisting with CBT-OB procedures after their discharge. Conclusion: Patients with obesity treated with CBT-OB and exposed to COVID-19 lockdown, despite achieving lower weight loss than non-exposed patients, had a healthy weight loss at 6-month follow-up and comparable reduction in binge-eating behaviors.

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