scholarly journals Advancing research on cognitive flexibility in eating disorders: The importance of distinguishing attentional set-shifting and reversal learning

2014 ◽  
Vol 47 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Jennifer E. Wildes ◽  
Erika E. Forbes ◽  
Marsha D. Marcus
Keyword(s):  
Eating Disorders ◽  
Cognitive Flexibility ◽  
Reversal Learning ◽  
Set Shifting ◽  
Attentional Set ◽  
Attentional Set Shifting

scholarly journals Reversal learning and attentional set-shifting in mice

2012 ◽  
Vol 62 (3) ◽  
pp. 1168-1174 ◽  
Author(s):  
Gregory B. Bissonette ◽  
Elizabeth M. Powell
Keyword(s):  
Reversal Learning ◽  
Set Shifting ◽  
Attentional Set ◽  
Attentional Set Shifting

Effect of a 5-HT7 Receptor Antagonist on Reversal Learning in the Rat Attentional Set-Shifting Test

2020 ◽  
Vol 12 (1) ◽  
pp. 42-48
Author(s):  
Alma Hrnjadovic ◽  
James Friedmann ◽  
Sandra Barhebreus ◽  
Patricia J. Allen ◽  
Bernat Kocsis
Keyword(s):  
Receptor Antagonist ◽  
Reversal Learning ◽  
Set Shifting ◽  
Attentional Set ◽  
Attentional Set Shifting

scholarly journals Fronto-striatal circuits for cognitive flexibility in far from onset Huntington’s disease: evidence from the Young Adult Study

2020 ◽  
pp. jnnp-2020-324104 ◽  
Author(s):  
Christelle Langley ◽  
Sarah Gregory ◽  
Katie Osborne-Crowley ◽  
Claire O'Callaghan ◽  
Paul Zeun ◽  
...  
Keyword(s):  
Young Adult ◽  
Functional Connectivity ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cognitive Flexibility ◽  
Study Cohort ◽  
Set Shifting ◽  
Attentional Set ◽  
Adult Study ◽  
Attentional Set Shifting

ObjectivesCognitive flexibility, which is key for adaptive decision-making, engages prefrontal cortex (PFC)-striatal circuitry and is impaired in both manifest and premanifest Huntington’s disease (pre-HD). The aim of this study was to examine cognitive flexibility in a far from onset pre-HD cohort to determine whether an early impairment exists and if so, whether fronto-striatal circuits were associated with this deficit.MethodsIn the present study, we examined performance of 51 pre-HD participants (mean age=29.22 (SD=5.71) years) from the HD Young Adult Study cohort and 53 controls matched for age, sex and IQ, on the Cambridge Neuropsychological Test Automated Battery (CANTAB) Intra-Extra Dimensional Set-Shift (IED) task. This cohort is unique as it is the furthest from disease onset comprehensively studied to date (mean years=23.89 (SD=5.96) years). The IED task measures visual discrimination learning, cognitive flexibility and specifically attentional set-shifting. We used resting-state functional MRI to examine whether the functional connectivity between specific fronto-striatal circuits was dysfunctional in pre-HD, compared with controls, and whether these circuits were associated with performance on the critical extradimensional shift stage.ResultsOur results demonstrated that the CANTAB IED task detects a mild early impairment in cognitive flexibility in a pre-HD group far from onset. Attentional set-shifting was significantly related to functional connectivity between the ventrolateral PFC and ventral striatum in healthy controls and to functional connectivity between the dorsolateral PFC and caudate in pre-HD participants.ConclusionWe postulate that this incipient impairment of cognitive flexibility may be associated with intrinsically abnormal functional connectivity of fronto-striatal circuitry in pre-HD.

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