scholarly journals Resting energy expenditure and plasma leptin levels in adolescent girls with anorexia nervosa

2003 ◽  
Vol 34 (1) ◽  
pp. 156-161 ◽  
Author(s):  
Yayoi Satoh ◽  
Toshiaki Shimizu ◽  
Tsubasa Lee ◽  
Kyoko Nishizawa ◽  
Megumi Iijima ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Energy Expenditure ◽  
Adolescent Girls ◽  
Resting Energy Expenditure ◽  
Plasma Leptin ◽  
Resting Energy

Changes in resting energy expenditure and body composition in anorexia nervosa patients during refeeding

1993 ◽  
Vol 93 (4) ◽  
pp. 434-438 ◽  
Author(s):  
Dean D Krahn ◽  
Cheryl Rock ◽  
Ronald E Dechert ◽  
Karen K Nairin ◽  
Sheryl A Hasse
Keyword(s):  
Body Composition ◽  
Anorexia Nervosa ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Resting Energy

scholarly journals Chronic Starvation Secondary to Anorexia Nervosa Is Associated With an Adaptive Suppression of Resting Energy Expenditure

2014 ◽  
Vol 99 (3) ◽  
pp. 908-914 ◽  
Author(s):  
Lisa Kosmiski ◽  
Sarah J. Schmiege ◽  
Margherita Mascolo ◽  
Jennifer Gaudiani ◽  
Philip S. Mehler
Keyword(s):  
Anorexia Nervosa ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Resting Energy

Abstract P189: Cardiac Repolarization and Resting Energy Expenditure in Patients Hospitalized With Severe Anorexia Nervosa

2011 ◽  
Vol 4 (suppl_1) ◽  
Author(s):  
Mori J Krantz ◽  
Utpal N Sagar ◽  
Carlin S Long ◽  
Jean T Barbey ◽  
Jennifer L Gaudiani ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Energy Expenditure ◽  
Correlation Coefficients ◽  
Resting Energy Expenditure ◽  
Categorical Variables ◽  
Cardiac Repolarization ◽  
Qtc Interval ◽  
Qtc Prolongation ◽  
Ecg Data ◽  
Resting Energy

Background and Objectives: Anorexia nervosa (AN) carries the highest mortality among psychiatric illnesses and disproportionately impacts women. QTc prolongation is believed to underlie this risk but is a subject of controversy as ECG data among patients with advanced AN is inadequately characterized. Moreover, previous studies have utilized non-digitized ECG data and therefore have limited measurement precision. We sought to determine the prevalence of QTc prolongation and assess its relationship to body mass index (BMI) and resting energy expenditure (REE) within a national AN referral center. Methods and analysis: We identified 34 patients hospitalized with severe AN. ECGs were obtained on admission then digitized and read with high-precision calipers by a single blinded electrophysiologist. We evaluated the proportion of patients with marked QTc prolongation defined as exceeding 0.500 seconds. Descriptive statistics were used to summarize continuous normally distributed data. Categorical variables were summarized with frequencies and percentages. Pearson's and Spearman's correlation coefficients were used to determine if there was an association between QTc and admission BMI and REE calculated using the Harris Benedict equation. Findings: A total of 31 of 34 (91.2%) patients were women, and median age was 27 years. The median weight on admission was 81.4 pounds and median BMI was 13.5 kg/m 2 (interquartile range 11.8 - 14.5) Mean heart rate was 58 bpm and mean QTc calculated by the Fridericia formula was 0.421 seconds. A QTc interval exceeding 0.500 seconds was seen in only one patient (4.8%). There was no significant correlation between QTcF and either BMI (-0.20, p=0.39) REE (+0.19, p=0.40) on hospital admission. Conclusions: QTc interval prolongation occurs infrequently among patients with severe anorexia nervosa; most exhibit normal cardiac repolarization even at the height of their illness. Disease severity as assessed by admission BMI and REE is not significantly correlated with the QTc interval. Beyond the need for larger studies, these findings suggest that other markers of sudden death should be investigated within this vulnerable population.

Serum leptin levels and resting energy expenditure during weight gain in a patient with anorexia nervosa: a case study

1999 ◽  
Vol 7 (5) ◽  
pp. 372-381 ◽  
Author(s):  
Anne Ballauff ◽  
Markus Schwickardi ◽  
Peter M. Wehmeier ◽  
Werner Blum ◽  
Joachim Frey ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Weight Gain ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Serum Leptin ◽  
Resting Energy

scholarly journals l-Tri-iodothyronine is a major determinant of resting energy expenditure in underweight patients with anorexia nervosa and during weight gain

2005 ◽  
Vol 152 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Simone Onur ◽  
Verena Haas ◽  
Anja Bosy-Westphal ◽  
Maren Hauer ◽  
Thomas Paul ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Weight Gain ◽  
Energy Expenditure ◽  
Plasma Concentrations ◽  
Resting Energy Expenditure ◽  
Normal Weight ◽  
Metabolic Adaptation ◽  
Dietary Record ◽  
Underweight Patients ◽  
Resting Energy

Objective: We aimed to define the effect of l-3,5,3′-tri-iodothyronine (T3) on metabolic adaptation in underweight patients with anorexia nervosa (AN) as well as during weight gain. Methods: This involved clinical investigation of 28 underweight patients with AN, who were compared with 49 normal-weight controls. A subgroup of 17 patients was followed during weight gain. Resting energy expenditure was measured by indirect calorimetry. Body composition was measured by anthropometry as well as bioelectrical impedance analysis. Energy intake (EI) was assessed by a 3-day dietary record. Plasma concentrations of thyroid hormones (thyroxine (T4), T3 and thyrotropin (TSH)) were analyzed by enzyme immunoassays. Results: When compared with normal-weight women, underweight patients with AN had reduced fat mass (FM) (−71.3%), fat-free mass (FFM) (−13.1%), resting energy expenditure (REE) (−21.8%), T3- (−33.4%) and T4-concentrations (−19.8%) at unchanged TSH. REE remained reduced after adjustment for FFM (−24.6%). T3 showed a close association with REE. This association remained after adjustment of REE for FFM. Treatment of underweight AN patients resulted in a mean weight gain of 8.3 kg. This was mainly explained by an increase in FM with small or no changes in FFM. REE and T3 also increased (+9.3% and +33.3% respectively) at unchanged TSH and T4. There was a highly significant association between weight gain-induced changes in T3 and changes in adjusted REE (r = 0.78, P < 0.001, based on Pearson’s correlation). An increase in plasma T3 concentrations of 1.8 pmol/l could explain an increase in REE of 0.6 MJ/day (that is, a 32% increase in T3 was associated with a 13% increase in REE). Conclusions: Our data provide evidence that the low T3 concentrations add to metabolic adaptation in underweight patients with AN. During weight gain, increases in T3 are associated with increases in REE, which is independent of FFM. Both results are evidence for a physiologic role of T3 in modulation of energy expenditure in humans.

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