Neural crest and placode roles in formation and patterning of cranial sensory ganglia in lamprey

Tian Yuan; Joshua R. York; David W. McCauley

doi:10.1002/dvg.23356

The cranial sensory ganglia in culture: Differences in the response of placode-derived and neural crest-derived neurons to nerve growth factor

Developmental Biology ◽

10.1016/0012-1606(85)90435-x ◽

1985 ◽

Vol 111 (1) ◽

pp. 62-72 ◽

Cited By ~ 78

Author(s):

Alun M. Davies ◽

Ronald M. Lindsay

Keyword(s):

Nerve Growth Factor ◽

Growth Factor ◽

Neural Crest ◽

Sensory Ganglia ◽

Nerve Growth ◽

Cranial Sensory Ganglia ◽

Culture Differences

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Compensatory defects associated with mutations in Hoxa1 restore normal palatogenesis to Hoxa2 mutants

Development ◽

10.1242/dev.126.22.5011 ◽

1999 ◽

Vol 126 (22) ◽

pp. 5011-5026 ◽

Cited By ~ 3

Author(s):

J.R. Barrow ◽

M.R. Capecchi

Keyword(s):

Cleft Palate ◽

Neural Crest ◽

Craniofacial Development ◽

Sensory Ganglia ◽

Craniofacial Skeleton ◽

Multiple Defects ◽

Abnormal Posture ◽

Gene Functions ◽

Craniofacial Defects ◽

Cranial Sensory Ganglia

The rhombencephalic neural crest play several roles in craniofacial development. They give rise to the cranial sensory ganglia and much of the craniofacial skeleton, and are vital for patterning of the craniofacial muscles. The loss of Hoxa1 or Hoxa2 function affects the development of multiple neural crest-derived structures. To understand how these two genes function together in craniofacial development, an allele was generated that disrupts both of these linked genes. Some of the craniofacial defects observed in the double mutants were additive combinations of those that exist in each of the single mutants, indicating that each gene functions independently in the formation of these structures. Other defects were found only in the double mutants demonstrating overlapping or synergistic functions. We also uncovered multiple defects in the attachments and trajectories of the extrinsic tongue and hyoid muscles in Hoxa2 mutants. Interestingly, the abnormal trajectory of two of these muscles, the styloglossus and the stylohyoideus, blocked the attachment of the hyoglossus to the greater horn of the hyoid, which in turn correlated exactly with the presence of cleft palate in Hoxa2 mutants. We suggest that the hyoglossus, whose function is to depress the lateral edges of the tongue, when unable to make its proper attachment to the greater horn of the hyoid, forces the tongue to adopt an abnormal posture which blocks closure of the palatal shelves. Unexpectedly, in Hoxa1/Hoxa2 double mutants, the penetrance of cleft palate is dramatically reduced. We show that two compensatory defects, associated with the loss of Hoxa1 function, restore normal attachment of the hyoglossus to the greater horn thereby allowing the palatal shelves to lift and fuse above the flattened tongue.

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Gene expression profiling of cranial sensory ganglia that transmit food intake stimuli

BioFactors ◽

10.1002/biof.552210104 ◽

2004 ◽

Vol 21 (1-4) ◽

pp. 15-18 ◽

Cited By ~ 2

Author(s):

Ichiro Matsumoto ◽

Shugo Nakamura ◽

Yasufumi Emori ◽

Soichi Arai ◽

Keiko Abe

Keyword(s):

Gene Expression ◽

Food Intake ◽

Gene Expression Profiling ◽

Expression Profiling ◽

Sensory Ganglia ◽

Cranial Sensory Ganglia

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Regulation of Chick Ebf1-3 Gene Expression in the Pharyngeal Arches, Cranial Sensory Ganglia and Placodes

Cells Tissues Organs ◽

10.1159/000369880 ◽

2014 ◽

Vol 199 (4) ◽

pp. 278-293 ◽

Cited By ~ 4

Author(s):

Mohammed Abu El-Magd ◽

Ayman A. Saleh ◽

Foad Farrag ◽

Reda M. Abd El-Aziz ◽

Haytham A. Ali ◽

...

Keyword(s):

Gene Expression ◽

Sensory Ganglia ◽

Pharyngeal Arches ◽

Cranial Sensory Ganglia

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Spatial and temporal distribution of vinculin and talin in migrating avian neural crest cells and their derivatives

Development ◽

10.1242/dev.108.3.421 ◽

1990 ◽

Vol 108 (3) ◽

pp. 421-433

Author(s):

J.L. Duband ◽

J.P. Thiery

Keyword(s):

Neural Crest ◽

Expression Patterns ◽

Temporal Distribution ◽

Neural Crest Cells ◽

Cell Types ◽

Avian Embryo ◽

Sensory Ganglia ◽

Adhesive Properties ◽

Final Destination ◽

Derivatives Of

Neural crest cells express different adhesion modes at each phase of their development starting with their separation from the neural tube, followed by migration along definite pathways throughout the embryo, and finally to settlement and differentiation in elected embryonic regions. In order to determine possible changes in the cytoskeleton organization and function during these processes, we have studied the in situ distribution of two major cytoskeleton-associated elements involved in the membrane anchorage of actin microfilaments, i.e. vinculin and talin, during the ontogeny of the neural crest and its derivatives in the avian embryo. Prior to emigration, neural crest cells exhibited both vinculin and talin at levels similar to the neighbouring neural epithelial cells, and this expression apparently did not change as cells became endowed with migratory properties. However, vinculin became selectively enhanced in neural crest cells as they further migrated towards their final destination. This increase in vinculin amount was particularly striking in vagal and truncal neural crest cells entering cellular environments, such as the sclerotome and the gut mesenchyme. Talin was also expressed by neural crest cells but, in contrast to vinculin, staining was not conspicuous compared to neighbouring mesenchymal cells. High levels of vinculin persisted throughout embryogenesis in almost all neural derivatives of the neural crest, including the autonomous and sensory ganglia and Schwann cells along the peripheral nerves. In contrast, the non-neural derivatives of the neural crest rapidly lost their prominent vinculin staining after migration. The pattern of talin in the progeny of the neural crest was complex and varied with the cell types: for example, some cranial sensory ganglia expressed high amounts of the molecule whereas autonomic ganglia were nearly devoid of it. Our results suggest that (i) vinculin and talin may follow independent regulatory patterns within the same cell population, (ii) the level of expression of vinculin and talin in neural crest cells may be consistent with the rapid, constant modulations of their adhesive properties, and (iii) the expression patterns of the two molecules may also be correlated with the genesis of the peripheral nervous system.

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