Hox genes: Downstream “effectors” of retinoic acid signaling in vertebrate embryogenesis

genesis ◽  
2019 ◽  
pp. e23306 ◽  
Author(s):  
Christof Nolte ◽  
Bony De Kumar ◽  
Robb Krumlauf
Keyword(s):  
Retinoic Acid ◽  
Hox Genes ◽  
Retinoic Acid Signaling ◽  
Downstream Effectors

scholarly journals Retinoic Acid Signaling in Vertebrate Hindbrain Segmentation: Evolution and Diversification

Diversity ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 398
Author(s):  
Alice M. H. Bedois ◽  
Hugo J. Parker ◽  
Robb Krumlauf
Keyword(s):  
Retinoic Acid ◽  
Regulatory Network ◽  
Hox Genes ◽  
Morphological Diversity ◽  
Retinoic Acid Signaling ◽  
Vertebrate Lineage ◽  
Axial Patterning ◽  
Process Thought ◽  
Key Drivers ◽  
Gene Regulatory

In metazoans, Hox genes are key drivers of morphogenesis. In chordates, they play important roles in patterning the antero-posterior (A-P) axis. A crucial aspect of their role in axial patterning is their collinear expression, a process thought to be linked to their response to major signaling pathways such as retinoic acid (RA) signaling. The amplification of Hox genes following major events of genome evolution can contribute to morphological diversity. In vertebrates, RA acts as a key regulator of the gene regulatory network (GRN) underlying hindbrain segmentation, which includes Hox genes. This review investigates how the RA signaling machinery has evolved and diversified and discusses its connection to the hindbrain GRN in relation to diversity. Using non-chordate and chordate deuterostome models, we explore aspects of ancient programs of axial patterning in an attempt to retrace the evolution of the vertebrate hindbrain GRN. In addition, we investigate how the RA signaling machinery has evolved in vertebrates and highlight key examples of regulatory diversification that may have influenced the GRN for hindbrain segmentation. Finally, we describe the value of using lamprey as a model for the early-diverged jawless vertebrate group, to investigate the elaboration of A-P patterning mechanisms in the vertebrate lineage.

scholarly journals Retinoic acid signaling targets Hox genes during the amphioxus gastrula stage: Insights into early anterior–posterior patterning of the chordate body plan

2010 ◽  
Vol 338 (1) ◽  
pp. 98-106 ◽  
Author(s):  
Demian Koop ◽  
Nicholas D. Holland ◽  
Marie Sémon ◽  
Susana Alvarez ◽  
Angel Rodriguez de Lera ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Hox Genes ◽  
Body Plan ◽  
Retinoic Acid Signaling ◽  
Gastrula Stage ◽  
Anterior Posterior

scholarly journals GABAergic differentiation in the basal ganglia requires retinoic acid signaling

2011 ◽  
Vol 356 (1) ◽  
pp. 181
Author(s):  
Christina Chatzi ◽  
Thomas Brade ◽  
Gregg Duester
Keyword(s):  
Retinoic Acid ◽  
Basal Ganglia ◽  
Retinoic Acid Signaling

scholarly journals Diencephalic Size Is Restricted by a Novel Interplay Between GCN5 Acetyltransferase Activity and Retinoic Acid Signaling

2017 ◽  
Vol 37 (10) ◽  
pp. 2565-2579 ◽  
Author(s):  
Jonathan J. Wilde ◽  
Julie A. Siegenthaler ◽  
Sharon Y.R. Dent ◽  
Lee A. Niswander
Keyword(s):  
Retinoic Acid ◽  
Retinoic Acid Signaling ◽  
Acetyltransferase Activity
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