Down syndrome cell adhesion molecule is important for early development inXenopus tropicalis

genesis ◽  
2014 ◽  
Vol 52 (10) ◽  
pp. 849-857 ◽  
Author(s):  
Heidi D. Morales Diaz
Keyword(s):  
Down Syndrome ◽  
Cell Adhesion ◽  
Early Development ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule

Synthesis and phosphorylation of uvomorulin during mouse early development

Development ◽  
1992 ◽  
Vol 115 (1) ◽  
pp. 313-318 ◽  
Author(s):  
M. Sefton ◽  
M.H. Johnson ◽  
L. Clayton
Keyword(s):  
Cell Adhesion ◽  
Early Development ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Blastocyst Stage ◽  
Embryonic Stage ◽  
Cell Stage ◽  
Mouse Oocytes ◽  
Maternal Mrna ◽  
Embryonic Genome

The cell adhesion molecule, uvomorulin, is synthesised in both the 135 × 10(3) M(r) precursor and 120 × 10(3) M(r) mature forms on maternal mRNA templates in unfertilized and newly fertilized mouse oocytes. Synthesis on maternal message ceases during the 2-cell stage to resume later on mRNA encoded presumptively by the embryonic genome. Uvomorulin is detectable by immunoblotting at all stages upto the blastocyst stage, but shows variations in its total amount and processing with embryonic stage. Whilst only trace levels of phosphorylated uvomorulin are detectable in early and late 4-cell embryos, uvomorulin in 8-cell embryos is phosphorylated.

scholarly journals Alternatively spliced down syndrome cell adhesion molecule (Dscam) controls innate immunity in crab

2019 ◽  
Vol 294 (44) ◽  
pp. 16440-16450 ◽  
Author(s):  
Dan Li ◽  
Zhicheng Wan ◽  
Xuejie Li ◽  
Ming Duan ◽  
Lei Yang ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Down Syndrome ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Alternatively Spliced

Herpes virus OsHV-1 and the protistPerkinsus marinusmodify the expression of the Down syndrome cell adhesion molecule gene in gill and mantle ofCrassostreaspp.

2018 ◽  
Vol 49 (11) ◽  
pp. 3638-3646 ◽  
Author(s):  
Lilián Arzeta-Pino ◽  
Armando Acosta ◽  
Maria E. Sarmiento ◽  
Maurilia Rojas-Contreras ◽  
Carmen Rodríguez-Jaramillo ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Herpes Virus ◽  
Adhesion Molecule Gene ◽  
Herpès Virus

scholarly journals Protein production, crystallization and preliminary crystallographic analysis of the four N-terminal immunoglobulin domains of Down syndrome cell adhesion molecule 1

2015 ◽  
Vol 71 (6) ◽  
pp. 775-778 ◽  
Author(s):  
Linna Cheng ◽  
Shu-Ang Li ◽  
Yamei Yu ◽  
Qiang Chen
Keyword(s):  
Down Syndrome ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Rna Splicing ◽  
Cell Adhesion Molecule ◽  
Crystallographic Analysis ◽  
Homophilic Binding ◽  
Ig Superfamily ◽  
Cell Adhesion Molecule 1 ◽  
Insight Into

Down syndrome cell adhesion molecule 1 (Dscam1), a member of the immunoglobulin (Ig) superfamily, plays important roles in both the nervous and the immune systems. Via alternative RNA splicing,DrosophilaDscam1 encodes a vast family of Ig-containing proteins that exhibit isoform-specific homophilic binding. Whether different Dscam1 isoforms adopt the same dimerization mode is under debate, and the detailed mechanism of Dscam1 specificity remains unclear. In this study, eight different isforms of Dscam1 Ig1–4 have been cloned, overexpressed, purified to homogeneity and crystallized. X-ray data were collected to 1.9–4.0 Å resolution. These structures will provide the opportunity to perform extensive structural comparisons of different Dscam1 isoforms and provide insight into its specificity.

Implication of “Down syndrome cell adhesion molecule” in the hippocampal neurogenesis of ischemic monkeys

Hippocampus ◽  
2006 ◽  
Vol 16 (11) ◽  
pp. 924-935 ◽  
Author(s):  
Tetsumori Yamashima ◽  
Boryana K. Popivanova ◽  
Jianzhong Guo ◽  
Susumu Kotani ◽  
Tomohiko Wakayama ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Cell Adhesion ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Hippocampal Neurogenesis
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