scholarly journals Podosomal proteins as causes of human syndromes: A role in craniofacial development?

genesis ◽  
2011 ◽  
Vol 49 (4) ◽  
pp. 209-221 ◽  
Author(s):  
Pilar Cejudo-Martin ◽  
Sara A. Courtneidge
Keyword(s):  
Craniofacial Development

scholarly journals Wolf-Hirschhorn Syndrome-Associated Genes Are Enriched in Motile Neural Crest Cells and Affect Craniofacial Development in Xenopus laevis

2019 ◽  
Vol 10 ◽  
Author(s):  
Alexandra Mills ◽  
Elizabeth Bearce ◽  
Rachael Cella ◽  
Seung Woo Kim ◽  
Megan Selig ◽  
...  
Keyword(s):  
Xenopus Laevis ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Craniofacial Development

The Pleiotropic Intricacies of Hedgehog Signaling: From Craniofacial Patterning to Carcinogenesis

FACE ◽  
2021 ◽  
pp. 273250162110243
Author(s):  
Mikhail Pakvasa ◽  
Andrew B. Tucker ◽  
Timothy Shen ◽  
Tong-Chuan He ◽  
Russell R. Reid
Keyword(s):  
Intracellular Signaling ◽  
Limb Development ◽  
Hedgehog Signaling ◽  
Target Genes ◽  
Craniofacial Development ◽  
Signaling Cascade ◽  
Signaling Mechanisms ◽  
Intracellular Signaling Cascade ◽  
And Function

Hedgehog signaling was discovered more than 40 years ago in experiments demonstrating that it is a fundamental mediator of limb development. Since that time, it has been shown to be important in development, homeostasis, and disease. The hedgehog pathway proceeds through a pathway highly conserved throughout animals beginning with the extracellular diffusion of hedgehog ligands, proceeding through an intracellular signaling cascade, and ending with the activation of specific target genes. A vast amount of research has been done elucidating hedgehog signaling mechanisms and regulation. This research has found a complex system of genetics and signaling that helps determine how organisms develop and function. This review provides an overview of what is known about hedgehog genetics and signaling, followed by an in-depth discussion of the role of hedgehog signaling in craniofacial development and carcinogenesis.

Vitamin K - its essential role in craniofacial development

1994 ◽  
Vol 39 (2) ◽  
pp. 88-92 ◽  
Author(s):  
Andrew M. Howe ◽  
William S. Webster
Keyword(s):  
Vitamin K ◽  
Essential Role ◽  
Craniofacial Development

In utero/lactational and adult exposures to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) show differential effects on craniofacial development and growth in rats

Toxicology ◽  
2015 ◽  
Vol 337 ◽  
pp. 30-38 ◽  
Author(s):  
Sabrina B. Sholts ◽  
Merja Korkalainen ◽  
Ulla Simanainen ◽  
Hanna M. Miettinen ◽  
Helen Håkansson ◽  
...  
Keyword(s):  
In Utero ◽  
Craniofacial Development ◽  
Differential Effects ◽  
Tetrachlorodibenzo P Dioxin

Genes, forces, and forms: Mechanical aspects of prenatal craniofacial development

2006 ◽  
Vol 235 (5) ◽  
pp. 1219-1229 ◽  
Author(s):  
Ralf J. Radlanski ◽  
Herbert Renz
Keyword(s):  
Craniofacial Development

scholarly journals Vgll2a is required for neural crest cell survival during zebrafish craniofacial development

2011 ◽  
Vol 357 (1) ◽  
pp. 269-281 ◽  
Author(s):  
Christopher W. Johnson ◽  
Laura Hernandez-Lagunas ◽  
Weiguo Feng ◽  
Vida Senkus Melvin ◽  
Trevor Williams ◽  
...  
Keyword(s):  
Neural Crest ◽  
Cell Survival ◽  
Neural Crest Cell ◽  
Craniofacial Development ◽  
Crest Cell

scholarly journals Ciliary Signalling and Mechanotransduction in the Pathophysiology of Craniosynostosis

Genes ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 1073
Author(s):  
Federica Tiberio ◽  
Ornella Parolini ◽  
Wanda Lattanzi
Keyword(s):  
Primary Cilium ◽  
Genetic Basis ◽  
Mendelian Inheritance ◽  
Craniofacial Development ◽  
Cranial Sutures ◽  
Craniofacial Malformation ◽  
Computational Annotation ◽  
Neural Crest Origin ◽  
Disease Associated Genes ◽  
Molecular Signals

Craniosynostosis (CS) is the second most prevalent inborn craniofacial malformation; it results from the premature fusion of cranial sutures and leads to dimorphisms of variable severity. CS is clinically heterogeneous, as it can be either a sporadic isolated defect, more frequently, or part of a syndromic phenotype with mendelian inheritance. The genetic basis of CS is also extremely heterogeneous, with nearly a hundred genes associated so far, mostly mutated in syndromic forms. Several genes can be categorised within partially overlapping pathways, including those causing defects of the primary cilium. The primary cilium is a cellular antenna serving as a signalling hub implicated in mechanotransduction, housing key molecular signals expressed on the ciliary membrane and in the cilioplasm. This mechanical property mediated by the primary cilium may also represent a cue to understand the pathophysiology of non-syndromic CS. In this review, we aimed to highlight the implication of the primary cilium components and active signalling in CS pathophysiology, dissecting their biological functions in craniofacial development and in suture biomechanics. Through an in-depth revision of the literature and computational annotation of disease-associated genes we categorised 18 ciliary genes involved in CS aetiology. Interestingly, a prevalent implication of midline sutures is observed in CS ciliopathies, possibly explained by the specific neural crest origin of the frontal bone.

Sleep-disordered breathing, craniofacial development, and neurodevelopment in premature infants: a 2-year follow-up study

2019 ◽  
Vol 60 ◽  
pp. 20-25 ◽  
Author(s):  
Yu-Shu Huang ◽  
Jen-Fu Hsu ◽  
Teresa Paiva ◽  
Wei-Chih Chin ◽  
I-Chia Chen ◽  
...  
Keyword(s):  
Premature Infants ◽  
Sleep Disordered Breathing ◽  
Craniofacial Development ◽  
Follow Up Study ◽  
Disordered Breathing
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