scholarly journals Transcription factor TEAD2 is involved in neural tube closure

genesis ◽  
2007 ◽  
Vol 45 (9) ◽  
pp. 577-587 ◽  
Author(s):  
Kotaro J. Kaneko ◽  
Matthew J. Kohn ◽  
Chengyu Liu ◽  
Melvin L. DePamphilis
Keyword(s):  
Transcription Factor ◽  
Neural Tube ◽  
Neural Tube Closure ◽  
Tube Closure

scholarly journals Aberrant Gcm1 expression mediates Wnt/β-catenin pathway activation in folate deficiency involved in neural tube defects

2021 ◽  
Vol 12 (3) ◽  
Author(s):  
Jianting Li ◽  
Qiu Xie ◽  
Jun Gao ◽  
Fang Wang ◽  
Yihua Bao ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Neural Tube ◽  
Neural Development ◽  
Folate Deficiency ◽  
Early Embryo ◽  
Neural Tube Closure ◽  
Anteroposterior Patterning ◽  
T Cell Factor ◽  
Pathway Activation ◽  
Tube Closure

AbstractWnt signaling plays a major role in early neural development. An aberrant activation in Wnt/β-catenin pathway causes defective anteroposterior patterning, which results in neural tube closure defects (NTDs). Changes in folate metabolism may participate in early embryo fate determination. We have identified that folate deficiency activated Wnt/β-catenin pathway by upregulating a chorion-specific transcription factor Gcm1. Specifically, folate deficiency promoted formation of the Gcm1/β-catenin/T-cell factor (TCF4) complex formation to regulate the Wnt targeted gene transactivation through Wnt-responsive elements. Moreover, the transcription factor Nanog upregulated Gcm1 transcription in mESCs under folate deficiency. Lastly, in NTDs mouse models and low-folate NTDs human brain samples,Gcm1and Wnt/β-catenin targeted genes related to neural tube closure are specifically overexpressed. These results indicated that low-folate level promoted Wnt/β-catenin signaling via activating Gcm1, and thus leaded into aberrant vertebrate neural development.

Whole Rat Embryos Require Methionine for Neural Tube Closure when Cultured on Cow Serum

1989 ◽  
Vol 119 (11) ◽  
pp. 1716-1725 ◽  
Author(s):  
Caroline N. D. Coelho ◽  
James A. Weber ◽  
Norman W. Klein ◽  
Willard G. Daniels ◽  
Thomas A Hoagland
Keyword(s):  
Neural Tube ◽  
Neural Tube Closure ◽  
Rat Embryos ◽  
Tube Closure

scholarly journals Novel Mode of Defective Neural Tube Closure in the Non-Obese Diabetic (NOD) Mouse Strain

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
J. Michael Salbaum ◽  
Claudia Kruger ◽  
Jacalyn MacGowan ◽  
Nils J. Herion ◽  
David Burk ◽  
...  
Keyword(s):  
Neural Tube ◽  
Mouse Strain ◽  
Nod Mouse ◽  
Neural Tube Closure ◽  
Tube Closure
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