From primordial germ cell to primordial follicle: mammalian female germ cell development

genesis ◽  
2006 ◽  
Vol 44 (12) ◽  
pp. 622-632 ◽  
Author(s):  
Melissa E. Pepling
Keyword(s):  
Germ Cell ◽  
Primordial Germ Cell ◽  
Primordial Follicle ◽  
Cell Development ◽  
Germ Cell Development ◽  
Female Germ Cell ◽  
Mammalian Female

scholarly journals PI3K/PTEN/AKT Signaling Pathways in Germ Cell Development and Their Involvement in Germ Cell Tumors and Ovarian Dysfunctions

2021 ◽  
Vol 22 (18) ◽  
pp. 9838
Author(s):  
Massimo De Felici ◽  
Francesca Gioia Klinger
Keyword(s):  
Germ Cell ◽  
Signaling Pathways ◽  
Ovarian Function ◽  
Primordial Germ Cells ◽  
Primordial Germ Cell ◽  
Germ Cell Tumors ◽  
Primordial Follicle ◽  
Akt Signaling ◽  
Cell Development ◽  
Germ Cell Development

Several studies indicate that the PI3K/PTEN/AKT signaling pathways are critical regulators of ovarian function including the formation of the germ cell precursors, termed primordial germ cells, and the follicular pool maintenance. This article reviews the current state of knowledge of the functional role of the PI3K/PTEN/AKT pathways during primordial germ cell development and the dynamics of the ovarian primordial follicle reserve and how dysregulation of these signaling pathways may contribute to the development of some types of germ cell tumors and ovarian dysfunctions.

scholarly journals Disorganization of the germ cell pool leads to primary ovarian insufficiency

Reproduction ◽  
2017 ◽  
Vol 153 (6) ◽  
pp. R205-R213 ◽  
Author(s):  
Ikko Kawashima ◽  
Kazuhiro Kawamura
Keyword(s):  
Germ Cell ◽  
Cell Biology ◽  
Embryonic Stem ◽  
Primordial Follicle ◽  
Cell Development ◽  
Primary Ovarian Insufficiency ◽  
Ovarian Insufficiency ◽  
Germ Cell Development ◽  
Female Germ Cell

The mammalian ovary is an organ that controls female germ cell development, storing them and releasing mature oocytes for transporting to the oviduct. During the fetal stage, female germ cells change from a proliferative state to meiosis before forming follicles with the potential for the growth of surrounding somatic cells. Understanding of molecular and physiological bases of germ cell development in the fetal ovary contributed not only to the elucidation of genetic disorders in primary ovarian insufficiency (POI), but also to the advancement of novel treatments for patients with POI. Accumulating evidence indicates that mutations inNOBOX,DAZLandFIGLAgenes are associated with POI. In addition, cell biology studies revealed the important roles of these genes as essential translational factors for germ cell development. Recent insights into the role of the PI3K (phosphatidylinositol 3-kinase)-Akt signaling pathway in primordial follicle activation allowed the development of a new infertility treatment, IVA (in vitroactivation), leading to successful pregnancy/delivery in POI patients. Furthermore, elucidation of genetic dynamics underlying female germ cell development could allow regeneration of oocytes from ES (embryonic stem)/iPS (induced pluripotent stem) cells in mammals. The purpose of this review is to summarize basic findings related to female germ cell development and potential clinical implications, especially focusing on POI etiologies. We also summarize evolving new POI therapies based on IVA as well as oocyte regeneration.

scholarly journals Female Germ Cell Development, Functioning and Associated Adversities under Unfavorable Circumstances

2021 ◽  
Vol 22 (4) ◽  
pp. 1979
Author(s):  
Dinesh Bharti ◽  
Manisha Tikka ◽  
Sang-Yun Lee ◽  
Eun-Yeong Bok ◽  
Hyeon-Jeong Lee ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Autocrine Signaling ◽  
Unprotected Sexual Intercourse ◽  
Germ Cell Development ◽  
Female Germ Cell ◽  
One Year

In the present era, infertility is one of the major issues which restricts many couples to have their own children. Infertility is the inability to achieve a clinical pregnancy after regular unprotected sexual intercourse for the period of one year or more. Various factors including defective male or female germ cell development, unhealthy and improper lifestyles, diseases like cancer and associated chemo-or-radiation therapies, congenital disorders, etc., may be responsible for infertility. Therefore, it is highly important to understand the basic concepts of germ cell development including primordial germ cell (PGC) formation, specification, migration, entry to genital ridges and their molecular mechanisms, activated pathways, paracrine and autocrine signaling, along with possible alteration which can hamper germ cell development and can cause adversities like cancer progression and infertility. Knowing all these aspects in a proper way can be very much helpful in improving our understanding about gametogenesis and finding possible ways to cure related disorders. Here in this review, various aspects of gametogenesis especially female gametes and relevant factors causing functional impairment have been thoroughly discussed.

scholarly journals Female Germ Cell Development, Functioning and Associated Adversities Under Unfavorable Circumstances

2021 ◽  
Author(s):  
Dinesh Bharti ◽  
Manisha Tikka ◽  
Sang-Yun Lee ◽  
Eun-Yeong Bok ◽  
Hyeon-Jeong Lee ◽  
...  
Keyword(s):  
Germ Cell ◽  
Cancer Progression ◽  
Molecular Mechanisms ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Autocrine Signaling ◽  
Unprotected Sexual Intercourse ◽  
Germ Cell Development ◽  
Female Germ Cell ◽  
One Year

In the present era, infertility is one of the major issues which restricts many couples to have their own kids. Infertility is the inability to achieve a clinical pregnancy after regular unprotected sexual intercourse for the period of one year or more. Various factors including defective male or female germ cell development, unhealthy and improper lifestyles, diseases like cancer and associated chemo-or-radiation therapies, congenital disorders etc. may be responsible for infertility. Therefore, it is highly important to understand the basic concepts of germ cell development including primordial germ cell (PGC) formation, specification, migration, entry to genital ridges and their molecular mechanisms, activated pathways, paracrine and autocrine signaling, along with possible alteration which can hamper germ cell development and can cause adversities like cancer progression and infertility. Knowing all these aspects in a proper way can be very much helpful in improving our understanding about gametogenesis and finding possible ways to cure related disorders. Here in this review, various aspects of gametogenesis especially female gametes and relevant factors causing functional impairment have been thoroughly discussed.

scholarly journals Persistent Requirement and Alteration of the Key Targets of PRDM1 During Primordial Germ Cell Development in Mice1

2016 ◽  
Vol 94 (1) ◽  
Author(s):  
Chika Yamashiro ◽  
Takayuki Hirota ◽  
Kazuki Kurimoto ◽  
Tomonori Nakamura ◽  
Yukihiro Yabuta ◽  
...  
Keyword(s):  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Germ Cell Development

scholarly journals MicroRNA Biogenesis Is Required for Mouse Primordial Germ Cell Development and Spermatogenesis

PLoS ONE ◽  
2008 ◽  
Vol 3 (3) ◽  
pp. e1738 ◽  
Author(s):  
Katsuhiko Hayashi ◽  
Susana M. Chuva de Sousa Lopes ◽  
Masahiro Kaneda ◽  
Fuchou Tang ◽  
Petra Hajkova ◽  
...  
Keyword(s):  
Germ Cell ◽  
Primordial Germ Cell ◽  
Cell Development ◽  
Microrna Biogenesis ◽  
Germ Cell Development ◽  
Mouse Primordial Germ Cell
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