Tissue-Specific effects of maizebronze gene promoter mutations induced byDs1 insertion and excision

1989 ◽  
Vol 10 (6) ◽  
pp. 412-424 ◽  
Author(s):  
Thomas D. Sullivan ◽  
John W. Schiefelbein ◽  
Oliver E. Nelson
Keyword(s):  
Gene Promoter ◽  
Tissue Specific ◽  
Specific Effects ◽  
Promoter Mutations

scholarly journals Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice.

1991 ◽  
Vol 266 (36) ◽  
pp. 24613-24620
Author(s):  
A. Subramaniam ◽  
W.K. Jones ◽  
J. Gulick ◽  
S. Wert ◽  
J. Neumann ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Gene Promoter ◽  
Chain Gene ◽  
Heavy Chain Gene ◽  
Myosin Heavy Chain Gene ◽  
Tissue Specific ◽  
Specific Regulation

scholarly journals Breaking-off tissue specific activity of the oil palm metallothionein-like gene promoter in T1 seedlings of tomato exposed to metal ions

2013 ◽  
Vol 170 (3) ◽  
pp. 346-354 ◽  
Author(s):  
Hossein Kamaladini ◽  
Siti Nor Akmar Abdullah ◽  
Maheran Abdul Aziz ◽  
Ismanizan Bin Ismail ◽  
Fatemeh Haddadi
Keyword(s):  
Metal Ions ◽  
Oil Palm ◽  
Specific Activity ◽  
Gene Promoter ◽  
Tissue Specific

Human globin gene promoter sequences are sufficient for specific expression of a hybrid gene transfected into tissue culture cells

1987 ◽  
Vol 7 (1) ◽  
pp. 398-402
Author(s):  
T Rutherford ◽  
A W Nienhuis
Keyword(s):  
Gene Expression ◽  
Globin Gene ◽  
Gene Promoter ◽  
Gene Promoters ◽  
Globin Genes ◽  
Specific Expression ◽  
Tissue Specific ◽  
Promoter Sequences ◽  
Erythroleukemia Cells ◽  
Murine Erythroleukemia

The contribution of the human globin gene promoters to tissue-specific transcription was studied by using globin promoters to transcribe the neo (G418 resistance) gene. After transfection into different cell types, neo gene expression was assayed by scoring colony formation in the presence of G418. In K562 human erythroleukemia cells, which express fetal and embryonic globin genes but not the adult beta-globin gene, the neo gene was expressed strongly from a fetal gamma- or embryonic zeta-globin gene promoter but only weakly from the beta promoter. In murine erythroleukemia cells which express the endogenous mouse beta genes, the neo gene was strongly expressed from both beta and gamma promoters. In two nonerythroid cell lines, human HeLa cells and mouse 3T3 fibroblasts, the globin gene promoters did not allow neo gene expression. Globin-neo genes were integrated in the erythroleukemia cell genomes mostly as a single copy per cell and were transcribed from the appropriate globin gene cap site. We conclude that globin gene promoter sequences extending from -373 to +48 base pairs (bp) (relative to the cap site) for the beta gene, -385 to +34 bp for the gamma gene, and -555 to +38 bp for the zeta gene are sufficient for tissue-specific and perhaps developmentally specific transcription.

Tissue-specific transcription of the mouse alpha-fetoprotein gene promoter is dependent on HNF-1

1989 ◽  
Vol 9 (10) ◽  
pp. 4204-4212
Author(s):  
M H Feuerman ◽  
R Godbout ◽  
R S Ingram ◽  
S M Tilghman
Keyword(s):  
Specific Binding ◽  
Gene Promoter ◽  
Binding Activity ◽  
Alpha Fetoprotein ◽  
Transient Expression Assay ◽  
Band Shift ◽  
Specific Expression ◽  
Tissue Specific ◽  
Cis Acting ◽  
Dnase I Footprinting

Previous work identified four upstream cis-acting elements required for tissue-specific expression of the alpha-fetoprotein (AFP) gene: three distal enhancers and a promoter. To further define the role of the promoter in regulating AFP gene expression, segments of the region were tested for the ability to direct transcription of a reporter gene in transient expression assay. Experiments showed that the region within 250 base pairs of the start of transcription was sufficient to confer liver-specific transcription. DNase I footprinting and band shift assays indicated that the region between -130 and -100 was recognized by two factors, one of which was highly sequence specific and found only in hepatoma cells. Competition assays suggested that the liver-specific binding activity was HNF-1, previously identified by its binding to other liver-specific promoters. Mutation of the HNF-1 recognition site at -120 resulted in a significant reduction in transcription in transfection assays, suggesting a biological role for HNF-1 in the regulation of AFP expression.

scholarly journals Prediction of tissue-specific effects of gene knockout on apoptosis in different anatomical structures of human brain

BMC Genomics ◽  
2015 ◽  
Vol 16 (S13) ◽  
Author(s):  
Evgeny D Petrovskiy ◽  
Olga V Saik ◽  
Evgeny S Tiys ◽  
Inna N Lavrik ◽  
Nikolay A Kolchanov ◽  
...  
Keyword(s):  
Human Brain ◽  
Gene Knockout ◽  
Anatomical Structures ◽  
Tissue Specific ◽  
Specific Effects

scholarly journals Tissue-specific effects of temperature on proteasome function

2020 ◽  
Vol 25 (3) ◽  
pp. 563-572 ◽  
Author(s):  
Johanna Pispa ◽  
Olli Matilainen ◽  
Carina I. Holmberg
Keyword(s):  
Tissue Specific ◽  
Specific Effects ◽  
Effects Of Temperature

Tissue-specific effects of sulfonylureas

2000 ◽  
Vol 14 (4) ◽  
pp. 192-196 ◽  
Author(s):  
Frances M Ashcroft ◽  
Fiona M Gribble
Keyword(s):  
Tissue Specific ◽  
Specific Effects

scholarly journals Tissue specific effects of feeds supplemented with grape pomace or olive oil mill wastewater on detoxification enzymes in sheep

2017 ◽  
Vol 4 ◽  
pp. 364-372 ◽  
Author(s):  
Efthalia Kerasioti ◽  
Zoi Terzopoulou ◽  
Ourania Komini ◽  
Ioannis Kafantaris ◽  
Sotiria Makri ◽  
...  
Keyword(s):  
Olive Oil ◽  
Grape Pomace ◽  
Detoxification Enzymes ◽  
Olive Oil Mill Wastewater ◽  
Tissue Specific ◽  
Specific Effects
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