YAP maintains the production of intermediate progenitor cells and upper‐layer projection neurons in the mouse cerebral cortex

2021 ◽  
Author(s):  
Yi‐Ching Su ◽  
Tzu‐Heng Hung ◽  
Tzu‐Fang Wang ◽  
Ying‐Hsuan Lee ◽  
Tsu‐Wei Wang ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Progenitor Cells ◽  
Projection Neurons ◽  
Mouse Cerebral Cortex

scholarly journals BMP signaling alters aquaporin-4 expression in the mouse cerebral cortex

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kazuya Morita ◽  
Naoyuki Matsumoto ◽  
Kengo Saito ◽  
Toshihide Hamabe-Horiike ◽  
Keishi Mizuguchi ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Molecular Mechanisms ◽  
Water Movement ◽  
Water Channel ◽  
Bmp Signaling ◽  
Aquaporin 4 ◽  
Mammalian Brain ◽  
Physiological Conditions ◽  
Pathological Conditions ◽  
Mouse Cerebral Cortex

AbstractAquaporin-4 (AQP4) is a predominant water channel expressed in astrocytes in the mammalian brain. AQP4 is crucial for the regulation of homeostatic water movement across the blood–brain barrier (BBB). Although the molecular mechanisms regulating AQP4 levels in the cerebral cortex under pathological conditions have been intensively investigated, those under normal physiological conditions are not fully understood. Here we demonstrate that AQP4 is selectively expressed in astrocytes in the mouse cerebral cortex during development. BMP signaling was preferentially activated in AQP4-positive astrocytes. Furthermore, activation of BMP signaling by in utero electroporation markedly increased AQP4 levels in the cerebral cortex, and inhibition of BMP signaling strongly suppressed them. These results indicate that BMP signaling alters AQP4 levels in the mouse cerebral cortex during development.

scholarly journals Modeling human‐specific interlaminar astrocytes in the mouse cerebral cortex

2020 ◽  
Vol 529 (4) ◽  
pp. 802-810
Author(s):  
Ragunathan Padmashri ◽  
Baiyan Ren ◽  
Braden Oldham ◽  
Yoosun Jung ◽  
Ryan Gough ◽  
...  
Keyword(s):  
Cerebral Cortex ◽  
Mouse Cerebral Cortex ◽  
Human Specific
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