scholarly journals Revisiting the human dental follicle: from tooth development to its association with unerupted or impacted teeth and pathological changes

2021 ◽  
Author(s):  
Victor Coutinho Bastos ◽  
Ricardo Santiago Gomez ◽  
Carolina Cavaliéri Gomes
Keyword(s):  
Tooth Development ◽  
Dental Follicle ◽  
Pathological Changes ◽  
Impacted Teeth

scholarly journals Study of Pathological Changes in the Dental Follicle of Disease-Free Impacted Third Molars

2018 ◽  
Vol 17 (4) ◽  
pp. 611-615 ◽  
Author(s):  
Victor de Mello Palma ◽  
Cristiane Cademartori Danesi ◽  
Cristiane Frantz Arend ◽  
Andressa Borin Venturini ◽  
Diego Segatto Blaya ◽  
...  
Keyword(s):  
Dental Follicle ◽  
Pathological Changes ◽  
Third Molars ◽  
Disease Free

scholarly journals Long-term follow-up in lower right second premolar tooth with a dental follicle but no tooth bud: A case report

2021 ◽  
Vol 11 (Suppl. 1) ◽  
pp. 312-315
Author(s):  
Yusuf Sukurica ◽  
Asu Çakır
Keyword(s):  
Case Report ◽  
Tooth Development ◽  
Development Stage ◽  
Dental Follicle ◽  
Primary Molar ◽  
Long Term Follow Up ◽  
Native Speakers Of English ◽  
The Right

Aim: The patient was followed up in consultation with the orthodontist, and after a long-term follow-up, it was found that the dental germ developed, but the position of the tooth was horizontal. When the follow-ups were continued, it was observed that the position of the tooth also improved, and it progressed smoothly along the tooth eruption path. Methodology: In the panoramic radiography of an 8-year-old male patient who applied to the clinic complaining about the left upper first primary molar tooth, the right lower permanent second premolar tooth follicle developed, but there was no tooth development in the follicle. Results: When follicle formation is observed, only following the patients without directing them to orthodontic treatment, which is expensive and difficult, positively affects their dental structure. Following patients without affecting their lives can be significant. Conclusion: We emphasize the importance of long-term follow-up when follicle formation was observed. We predicted that this situation was caused by the disconnection in the interaction of transcription factors and signals in the tooth development stage.   How to cite this article: Sukurica Y, Çakır A. Long-term follow-up in lower right second premolar tooth with a dental follicle but no tooth bud: A case report. Int Dent Res 2021;11(Suppl.1):312-5. https://doi.org/10.5577/10.5577/intdentres.2021.vol11.suppl1.47   Linguistic Revision: The English in this manuscript has been checked by at least two professional editors, both native speakers of English.

scholarly journals Dental Follicle Cells: Roles in Development and Beyond

2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Tao Zhou ◽  
Jinhai Pan ◽  
Peiyao Wu ◽  
Ruijie Huang ◽  
Wei Du ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Clinical Application ◽  
Alveolar Bone ◽  
Tooth Development ◽  
Tooth Germ ◽  
Follicle Cells ◽  
Tooth Root ◽  
Dental Follicle ◽  
Mesenchymal Progenitor Cells ◽  
Dental Follicle Cells

Dental follicle cells (DFCs) are a group of mesenchymal progenitor cells surrounding the tooth germ, responsible for cementum, periodontal ligament, and alveolar bone formation in tooth development. Cascades of signaling pathways and transcriptional factors in DFCs are involved in directing tooth eruption and tooth root morphogenesis. Substantial researches have been made to decipher multiple aspects of DFCs, including multilineage differentiation, senescence, and immunomodulatory ability. DFCs were proved to be multipotent progenitors with decent amplification, immunosuppressed and acquisition ability. They are able to differentiate into osteoblasts/cementoblasts, adipocytes, neuron-like cells, and so forth. The excellent properties of DFCs facilitated clinical application, as exemplified by bone tissue engineering, tooth root regeneration, and periodontium regeneration. Except for the oral and maxillofacial regeneration, DFCs were also expected to be applied in other tissues such as spinal cord defects (SCD), cardiomyocyte destruction. This article reviewed roles of DFCs in tooth development, their properties, and clinical application potentials, thus providing a novel guidance for tissue engineering.

scholarly journals Detection of the gubernacular canal and its attachment to the dental follicle may indicate an abnormal eruption status

2019 ◽  
Vol 89 (5) ◽  
pp. 781-787 ◽  
Author(s):  
Hugo Gaêta-Araujo ◽  
Matheus Bronetti da Silva ◽  
Camila Tirapelli ◽  
Deborah Queiroz Freitas ◽  
Christiano de Oliveira-Santos
Keyword(s):  
Tooth Eruption ◽  
Dental Follicle ◽  
Chi Square ◽  
Tooth Formation ◽  
Detection Rates ◽  
Impacted Teeth ◽  
Significance Level ◽  
Attachment Sites ◽  
Delayed Eruption ◽  
Unerupted Teeth

ABSTRACT Objectives: To evaluate and compare the detection of gubernacular canals (GC) and their characteristics in normal and abnormal tooth eruption. Materials and Methods: Patients with unerupted teeth were classified according to sex and age. Each tooth was classified according to dental group, eruption status, formation status, angulation, and GC detection. The opening of the GC in the alveolar crest and the attachment sites in relation to the dental follicle were assessed. Data were analyzed by the chi-square and Kruskal-Wallis tests, with a significance level of 5%. Results: Cone-beam computed tomography scans of 159 patients were evaluated. The final sample (N = 598) consisted of 423 teeth with normal eruption, 140 impacted teeth, and 35 teeth with delayed eruption. The overall detection rate of GC was 90.6%. These rates were 94.1%, 87.1%, and 62.9% for normal eruption, impacted teeth, and delayed eruption, respectively. GC detection rates were higher in the early stages of tooth formation in normal tooth eruption and in impacted teeth. The rate of GC detection was even lower in delayed teeth when they were angulated. Unusual attachment sites of the GC to the dental follicle were associated with abnormal eruption status. Conclusions: The results of the present study suggest that GC characteristics may indicate an abnormal eruption status.

scholarly journals Function of Dental Follicle Progenitor/Stem Cells and Their Potential in Regenerative Medicine: From Mechanisms to Applications

Biomolecules ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 997
Author(s):  
Ruiye Bi ◽  
Ping Lyu ◽  
Yiming Song ◽  
Peiran Li ◽  
Dongzhe Song ◽  
...  
Keyword(s):  
Stem Cells ◽  
Regenerative Medicine ◽  
Bone Repair ◽  
Alveolar Bone ◽  
Tooth Development ◽  
Current Knowledge ◽  
Critical Role ◽  
Deep Understanding ◽  
Dental Follicle ◽  
Application Potential

Dental follicle progenitor/stem cells (DFPCs) are a group of dental mesenchyme stem cells that lie in the dental follicle and play a critical role in tooth development and maintaining function. Originating from neural crest, DFPCs harbor a multipotential differentiation capacity. More importantly, they have superiorities, including the easy accessibility and abundant sources, active self-renewal ability and noncontroversial sources compared with other stem cells, making them an attractive candidate in the field of tissue engineering. Recent advances highlight the excellent properties of DFPCs in regeneration of orofacial tissues, including alveolar bone repair, periodontium regeneration and bio-root complex formation. Furthermore, they play a unique role in maintaining a favorable microenvironment for stem cells, immunomodulation and nervous related tissue regeneration. This review is intended to summarize the current knowledge of DFPCs, including their stem cell properties, physiological functions and clinical application potential. A deep understanding of DFPCs can thus inspire novel perspectives in regenerative medicine in the future.

scholarly journals Matrix Metalloproteinase 2: A Possible Role inTooth Development and Eruption

2019 ◽  
Vol 21 (1) ◽  
pp. 41-51
Author(s):  
Nathália G. Sandoval DDS, MSc ◽  
Nayra S. C. Lima DDS, MSc ◽  
Willian G. Bautz DDS, PhD ◽  
Leticia N. Gama-de-Souza DDS, PhD ◽  
Karla L. A. Coburn DDS, PhD
Keyword(s):  
Lamina Propria ◽  
Germ Cells ◽  
Alveolar Bone ◽  
Bone Cells ◽  
Tooth Development ◽  
Tooth Eruption ◽  
Matrix Metalloproteinase 2 ◽  
Enamel Organ ◽  
Dental Follicle ◽  
Dental Papilla

Introduction: Tooth development results from a highly coordinated epithelial-mesenchyme interaction in which mesenchyme cells originate the dental papilla and dental follicle, while ectodermal cells originate the enamel organ. Simultaneously, bone tissue is formed around the developing tooth, trapping it in a bony crypt. Tooth eruption requires the resorption of the coronal part of the bony crypt, followed by degradation of the lamina propria, most likely by metalloproteinases (MMPs) activity. Objectives:  The aim of this research was to determine MMP-2 expression in the dental germ cells (ameloblasts, odontoblasts, dental papilla and dental follicle) and surrounding tissues (alveolar bone and lamina propria) of rat molars throughout the eruptive process. Material and Methods: A total of 24 rats (4,6,9,11,14 and 16 days old) were used in this study. MMP-2 was detected through immunohistochemistry. A qualitative analysis was performed to investigate the expression of MMP-2 in the dental germ cells, lamina propria, and coronal and basal regions of the bony crypt. Results: MMP-2 expression was observed in the dental papilla cells, dental follicle, ameloblasts, odontoblasts and bone cells from the coronal and basal regions of the bony crypt. MMP-2 was also detected in the lamina propria during the mucosal penetration stage of tooth eruption. Conclusion: We conclude that MMP-2 may be important for the extracellular matrix rearrangement necessary for tooth development and secretion of its mineralized tissues.  We also conclude that MMP-2 may play a role in the extensive tissue remodeling during the intra-and-extra-osseous phases of the tooth eruption process.

Induction of Salivary Gland–Like Cells from Dental Follicle Epithelial Cells

2017 ◽  
Vol 96 (9) ◽  
pp. 1035-1043 ◽  
Author(s):  
Q.L. Xu ◽  
A. Furuhashi ◽  
Q.Z. Zhang ◽  
C.M. Jiang ◽  
T.-H. Chang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Salivary Gland ◽  
Epithelial Cells ◽  
Tooth Development ◽  
Ex Vivo ◽  
Dental Follicle ◽  
Epithelial Stem Cells ◽  
Cell Based Therapy ◽  
Promising Source

The dental follicle (DF), most often associated with unerupted teeth, is a condensation of ectomesenchymal cells that surrounds the tooth germ in early stages of tooth development. In the present study, we aim to isolate epithelial stem-like cells from the human DF and explore their potential differentiation into salivary gland (SG) cells. We demonstrated the expression of stem cell–related genes in the epithelial components of human DF tissues, and these epithelial progenitor cells could be isolated and ex vivo expanded in a reproducible manner. The human DF-derived epithelial cells possessed clonogenic and sphere-forming capabilities, as well as expressed a panel of epithelial stem cell–related genes, thus conferring stem cell properties (hDF-EpiSCs). When cultured under in vitro 3-dimensional induction conditions, hDF-EpiSCs were capable to differentiate into SG acinar and duct cells. Furthermore, transplantation of hDF-EpiSC–loaded native de-cellularized rat parotid gland scaffolds into the renal capsule of nude mice led to the differentiation of transplanted hDF-EpiSCs into salivary gland–like cells. These findings suggest that hDF-EpiSCs might be a promising source of epithelial stem cells for the development of stem cell–based therapy or bioengineering SG tissues to repair/regenerate SG dysfunction.

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