scholarly journals Time‐sequenced transcriptomes of developing distal mouse limb buds: A comparative tissue layer analysis

2021 ◽  
Author(s):  
M. Fernandez‐Guerrero ◽  
S. Zdral ◽  
A. Castilla‐Ibeas ◽  
L. Lopez‐Delisle ◽  
D. Duboule ◽  
...  
Keyword(s):  
Tissue Layer ◽  
Limb Buds ◽  
Layer Analysis ◽  
Distal Mouse ◽  
Mouse Limb

scholarly journals When Wnts antagonize Wnts

2003 ◽  
Vol 162 (5) ◽  
pp. 753-756 ◽  
Author(s):  
Gilbert Weidinger ◽  
Randall T. Moon
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathways ◽  
Limb Bud ◽  
Zebrafish Embryos ◽  
Previous Hypothesis ◽  
Distal Mouse ◽  
Wnt Ligands ◽  
Mouse Limb ◽  
Ectopic Activation ◽  
Canonical Wnt

Secreted Wnt ligands appear to activate a variety of signaling pathways. Two papers in this issue now present genetic evidence that “noncanonical” Wnt signaling inhibits the “canonical” Wnt/β-catenin pathway. Westfall et al. (2003a) show that zebrafish embryos lacking maternal Wnt-5 function are dorsalized due to ectopic activation of β-catenin, whereas Topol et al. (2003) report that chondrogenesis in the distal mouse limb bud depends on inhibition of Wnt/β-catenin signaling by a paralogue of Wnt-5. These studies present the first genetic confirmation of the previous hypothesis that vertebrate Wnt signaling pathways can act in an antagonistic manner.

scholarly journals Conserved cis-regulatory regions in a large genomic landscape control SHH and BMP-regulated Gremlin1 expression in mouse limb buds

2012 ◽  
Vol 12 (1) ◽  
pp. 23 ◽  
Author(s):  
Aimée Zuniga ◽  
Frédéric Laurent ◽  
Javier Lopez-Rios ◽  
Christian Klasen ◽  
Nicolas Matt ◽  
...  
Keyword(s):  
Limb Buds ◽  
Regulatory Regions ◽  
Genomic Landscape ◽  
Mouse Limb ◽  
Landscape Control

Induction of skeletal malformations in organ cultures of mouse limb buds

1975 ◽  
Vol 31 (2) ◽  
pp. 227-228 ◽  
Author(s):  
B. Zimmermann ◽  
D. Neubert ◽  
D. Bachmann ◽  
H. -J. Merker
Keyword(s):  
Organ Cultures ◽  
Limb Buds ◽  
Skeletal Malformations ◽  
Mouse Limb
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