Sox14 is essential for initiation of neuronal differentiation in the chick spinal cord

2021 ◽  
Author(s):  
Taiki Katsuyama ◽  
Minori Kadoya ◽  
Manabu Shirai ◽  
Noriaki Sasai
Keyword(s):  
Spinal Cord ◽  
Neuronal Differentiation ◽  
Chick Spinal Cord

Onset of neuronal differentiation is regulated by paraxial mesoderm and requires attenuation of FGF signalling

Development ◽  
2002 ◽  
Vol 129 (7) ◽  
pp. 1681-1691 ◽  
Author(s):  
Ruth Diez del Corral ◽  
Dorette N. Breitkreuz ◽  
Kate G. Storey
Keyword(s):  
Spinal Cord ◽  
Neuronal Differentiation ◽  
Inverse Relationship ◽  
Neural Cell ◽  
Paraxial Mesoderm ◽  
Cell Fates ◽  
Neural Genes ◽  
Fgf Signalling ◽  
Somitic Mesoderm ◽  
Chick Spinal Cord

While many neuronal differentiation genes have been identified, we know little about what determines when and where neurons will form and how this process is coordinated with the differentiation of neighbouring tissues. In most vertebrates the onset of neuronal differentiation takes place in the spinal cord in a head to tail sequence. Here we demonstrate that the changing signalling properties of the adjacent paraxial mesoderm control the progression of neurogenesis in the chick spinal cord. We find an inverse relationship between the expression of caudal neural genes in the prospective spinal cord, which is maintained by underlying presomitic mesoderm and FGF signalling, and neuronal differentiation, which is repressed by such signals and accelerated by somitic mesoderm. We show that key to this interaction is the ability of somitic mesoderm to repress Fgf8 transcription in the prospective spinal cord. Our findings further indicate that attenuation of FGF signalling in the prospective spinal cord is a prerequisite for the onset of neuronal differentiation and may also help to resolve mesodermal and neural cell fates. However, inhibition of FGF signalling alone does not promote the formation of neurons, which requires still further somite signalling. We propose a model in which signalling from somitic tissue promotes the differentiation of the spinal cord and serves to co-ordinate neural and mesodermal development.

Species differences in the distribution and coexistence ratio of serotonin and substance P in the monkey, cat, rat and chick spinal cord

1991 ◽  
Vol 132 (2) ◽  
pp. 155-158 ◽  
Author(s):  
Nobuo Okado ◽  
Mutsumi Matsukawa ◽  
Shinobu Noritake ◽  
Shigeru Ozaki ◽  
Shun Hamada ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Substance P ◽  
Species Differences ◽  
Chick Spinal Cord

Neuronotrophic effects of skeletal muscle fractions on spinal cord differentiation

Development ◽  
1982 ◽  
Vol 71 (1) ◽  
pp. 83-95
Author(s):  
L. Hsu ◽  
D. Natyzak ◽  
G. L. Trupin
Keyword(s):  
Skeletal Muscle ◽  
Spinal Cord ◽  
Neuronal Migration ◽  
Prolonged Treatment ◽  
Embryonic Chick ◽  
Neuronal Responses ◽  
Normal Muscle ◽  
Glial Development ◽  
Independent Effects ◽  
Chick Spinal Cord

Soluble fractions of homogenized skeletal muscle were found to promote neuronal migration and neuritic and glial outgrowth from embryonic chick spinal cord explants. Fractions obtained from skeletal muscle immobilized by prolonged treatment with curare were significantly more effective than normal muscle in accelerating neuronal and glial development. Fractions from other tissues such as brain and lung did not enhance neuronal differentiation, but were effective in stimulating outgrowth of glial cells. Separate measurements of glial and neuronal responses indicate that tissue fractions produce independent effects on the glial and neuronal components.

scholarly journals Lineage, arrangement, and death of clonally related motoneurons in chick spinal cord

1990 ◽  
Vol 10 (7) ◽  
pp. 2451-2462 ◽  
Author(s):  
SM Leber ◽  
SM Breedlove ◽  
JR Sanes
Keyword(s):  
Spinal Cord ◽  
Chick Spinal Cord

scholarly journals Coordination of progenitor specification and growth in mouse and chick spinal cord

Science ◽  
2014 ◽  
Vol 345 (6204) ◽  
pp. 1254927-1254927 ◽  
Author(s):  
A. Kicheva ◽  
T. Bollenbach ◽  
A. Ribeiro ◽  
H. P. Valle ◽  
R. Lovell-Badge ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Chick Spinal Cord

Neurotrophic factors BDNF and GDNF protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo

1999 ◽  
Vol 112 (1) ◽  
pp. 99-106 ◽  
Author(s):  
Douglas M Bradley ◽  
Francesca D Beaman ◽  
D.Blaine Moore ◽  
Kara Kidd ◽  
Marieta Barrow Heaton
Keyword(s):  
Spinal Cord ◽  
Neurotrophic Factors ◽  
Embryonic Chick ◽  
Chick Spinal Cord
Sign in / Sign up

Export Citation Format

Share Document