scholarly journals Hypoxia inducible factor‐2α importance for migration, proliferation, and self‐renewal of trunk neural crest cells

2020 ◽  
Author(s):  
Camilla U. Niklasson ◽  
Elina Fredlund ◽  
Emanuela Monni ◽  
Jessica M. Lindvall ◽  
Zaal Kokaia ◽  
...  
Keyword(s):  
Neural Crest ◽  
Hypoxia Inducible Factor ◽  
Neural Crest Cells ◽  
Self Renewal ◽  
Trunk Neural Crest

scholarly journals Cancer-associated HIF-2α impacts trunk neural crest stemness

2020 ◽  
Author(s):  
Sofie Mohlin ◽  
Camilla U. Persson ◽  
Elina Fredlund ◽  
Emanuela Monni ◽  
Jessica M. Lindvall ◽  
...  
Keyword(s):  
Neural Crest ◽  
Normal Development ◽  
Hypoxia Inducible Factor ◽  
Neural Crest Cells ◽  
Sympathetic Ganglia ◽  
Stem Cell Population ◽  
Neural Crest Development ◽  
Trunk Neural Crest

AbstractThe neural crest is a stem cell population that gives rise to sympathetic ganglia, the cell type of origin of neuroblastoma. Hypoxia Inducible Factor (HIF)-2α is associated with high risk neuroblastoma, however, little is known about its role in normal neural crest development. To address this important question, here we show that HIF-2α is expressed in trunk neural crest cells of human, murine and avian embryos. Modulating HIF-2α in vivo not only causes developmental delays but also induces proliferation and stemness of neural crest cells while altering the number of cells migrating ventrally to sympathoadrenal sites. Transcriptome changes after loss of HIF-2α reflect the in vivo phenotype. The results suggest that expression levels of HIF-2α must be strictly controlled and abnormal levels increase stemness and may promote metastasis. Our findings help elucidate the role of HIF-2α during normal development with implications also in tumor initiation at the onset of neuroblastoma.

scholarly journals Molecular and Cellular Features of Murine Craniofacial and Trunk Neural Crest Cells as Stem Cell-Like Cells

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e84072 ◽  
Author(s):  
Kunie Hagiwara ◽  
Takeshi Obayashi ◽  
Nobuyuki Sakayori ◽  
Emiko Yamanishi ◽  
Ryuhei Hayashi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Crest ◽  
Neural Crest Cells ◽  
Trunk Neural Crest

scholarly journals Characterization of late emerging trunk neural crest cells in the turtle Trachemys scripta

2010 ◽  
Vol 344 (1) ◽  
pp. 531
Author(s):  
Judith A. Cebra-Thomas ◽  
James Robinson ◽  
Melinda Yin ◽  
James McCarthy ◽  
Sonal Shah ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Trachemys Scripta ◽  
Trunk Neural Crest

scholarly journals Matrigel supports neural, melanocytic and chondrogenic differentiation of trunk neural crest cells

2013 ◽  
Vol 57 (11-12) ◽  
pp. 885-890 ◽  
Author(s):  
Ana B. Ramos-Hryb ◽  
Meline C. Da-Costa ◽  
Andréa G. Trentin ◽  
Giordano W. Calloni
Keyword(s):  
Neural Crest ◽  
Chondrogenic Differentiation ◽  
Neural Crest Cells ◽  
Trunk Neural Crest

An SEM analysis of neural crest migration in the mouse

Development ◽  
1983 ◽  
Vol 74 (1) ◽  
pp. 97-118
Author(s):  
C. A. Erickson ◽  
J. A. Weston
Keyword(s):  
Neural Crest ◽  
Basal Lamina ◽  
Neural Tube ◽  
Neural Crest Cells ◽  
Sem Analysis ◽  
Basement Membranes ◽  
Dorsal Neural Tube ◽  
Trunk Neural Crest ◽  
Unique Cell ◽  
Neural Crest Migration

The cellular morphology and migratory pathways of the trunk neural crest are described in normal mouse embryos, and in embryos homozygous for Patch in which neural crest derivatives develop abnormally. Trunk neural crest cells initially appear in 8½-day embryos as a unique cell population on the dorsal neural tube surface and are relatively rounded. Once they begin to migrate the cells flatten and orient somewhat tangentially to the neural tube, and advance ventrad between the somites and neural tube. At the onset of migration neural crest cells extend lamellipodia onto the surface of the tube while detaching their trailing processes from the lumenal surface. The basal lamina on the dorsal neural tube is discontinuous when cell migration begins in this region. As development proceeds, the basal lamina gradually becomes continuous from a lateral to dorsal direction and neural crest emigration is progressively confined to the narrowing region of discontinuous basal lamina. Cell separation from the neural tube ceases concomitant with completion of a continuous basement membrane. Preliminary observations of the mutant embryos reveal that abnormal extracellular spaces appear and patterns of crest migration are subsequently altered. We conclude that the extracellular matrix, extracellular spaces and basement membranes may delimit crest migration in the mouse.

scholarly journals Transcriptome dataset of trunk neural crest cells migrating along the ventral pathway of chick embryos

Data in Brief ◽  
2018 ◽  
Vol 21 ◽  
pp. 2547-2553 ◽  
Author(s):  
Christina Murko ◽  
Felipe Monteleone Vieceli ◽  
Marianne Bronner
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Chick Embryos ◽  
Ventral Pathway ◽  
Trunk Neural Crest

scholarly journals Trunk neural crest cells form an ectomesenchymal dermis in the turtle plastron

2011 ◽  
Vol 356 (1) ◽  
pp. 251
Author(s):  
Judith A. Cebra-Thomas ◽  
Sonal Shah ◽  
Gulnar Mangat ◽  
Tania Doles ◽  
Anne Terrell ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Trunk Neural Crest

scholarly journals Late-emigrating trunk neural crest cells in turtle embryos generate an osteogenic ectomesenchyme in the plastron

2013 ◽  
Vol 242 (11) ◽  
pp. 1223-1235 ◽  
Author(s):  
Judith A. Cebra-Thomas ◽  
Anne Terrell ◽  
Kayla Branyan ◽  
Sonal Shah ◽  
Ritva Rice ◽  
...  
Keyword(s):  
Neural Crest ◽  
Neural Crest Cells ◽  
Trunk Neural Crest
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