scholarly journals Morphoregulatory pathways in prostate ductal development

2017 ◽  
Vol 246 (2) ◽  
pp. 89-99 ◽  
Author(s):  
Monica Montano ◽  
Wade Bushman
Keyword(s):  
Ductal Development

scholarly journals Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth

Neoplasia ◽  
2017 ◽  
Vol 19 (6) ◽  
pp. 496-508 ◽  
Author(s):  
Anisha M. Hammer ◽  
Gina M. Sizemore ◽  
Vasudha C. Shukla ◽  
Alex Avendano ◽  
Steven T. Sizemore ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Matrix Stiffness ◽  
Ductal Development

scholarly journals Androgen receptor DNA methylation regulates the timing and androgen sensitivity of mouse prostate ductal development

2014 ◽  
Vol 396 (2) ◽  
pp. 237-245 ◽  
Author(s):  
Kimberly P. Keil ◽  
Lisa L. Abler ◽  
Jimena Laporta ◽  
Helene M. Altmann ◽  
Bing Yang ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Androgen Receptor ◽  
Mouse Prostate ◽  
Androgen Sensitivity ◽  
Ductal Development

scholarly journals Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland

2021 ◽  
pp. 002215542110137
Author(s):  
Shinya Matsuoka ◽  
Hiroyoshi Suzuki ◽  
Chieko Kato ◽  
Mai Kamikawa-Tokai ◽  
Akihiro Kamikawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Adhesion ◽  
Mammary Gland ◽  
Epithelial Mesenchymal Transition ◽  
Combined Treatment ◽  
Myoepithelial Cells ◽  
Mouse Mammary Gland ◽  
Mesenchymal Transition ◽  
Ovariectomized Mice ◽  
Ductal Development

Grainyhead-like 2 (Grhl2) is a transcription factor regulating cell adhesion genes. Grhl2 acts as an epithelial–mesenchymal transition suppressor, and it is a proto-oncogene involved in estrogen-stimulated breast cancer proliferation. However, its expression during ovarian hormone–dependent mammary ductal development remains obscure. We here examined Grhl2 expression in the mammary gland of normal and steroid-replaced ovariectomized mice. Grhl2 protein signals were detected in both the mammary luminal epithelial and myoepithelial nuclei. The ratio and density of Grhl2-positive nuclei increased after the onset of puberty and progressed with age, whereas Grhl2-negative epithelial cells were detected in mature ducts. Claudin 3, claudin 4, claudin 7, and E-cadherin gene expression in the mammary gland was upregulated, and their expression was highly correlated with Grhl2 gene expression. Furthermore, Grhl2 mRNA expression and ductal lumen width were significantly increased by the combined treatment of estrogen and progesterone compared with estrogen alone. These results suggest that Grhl2 expressed in the luminal epithelial and myoepithelial cells from the early phase of ductal development, controlling the expression of cell adhesion molecules to establish functional ducts:

scholarly journals In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci

2015 ◽  
Vol 26 (1-2) ◽  
pp. 57-79 ◽  
Author(s):  
Darryl L. Hadsell ◽  
Louise A. Hadsell ◽  
Walter Olea ◽  
Monique Rijnkels ◽  
Chad J. Creighton ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Qtl Mapping ◽  
In Silico ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Ductal Development

Abstract 4337: PDGFR-α induced stiffness abrogates mammary ductal development and enhances tumorigenesisin vivo

2017 ◽  
Author(s):  
Anisha Mathur Hammer ◽  
Gina M. Sizemore ◽  
Vasudha Shukla ◽  
Steven T. Sizemore ◽  
Maria Cuitino ◽  
...  
Keyword(s):  
Ductal Development

scholarly journals The Role of Csmd1 during Mammary Gland Development

Genes ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 162
Author(s):  
Samuel J. Burgess ◽  
Hannah Gibbs ◽  
Carmel Toomes ◽  
Patricia L. Coletta ◽  
Sandra M. Bell
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
Expression Patterns ◽  
Development In Vitro ◽  
Duct Development ◽  
Gland Development ◽  
Ductal Development

The Cub Sushi Multiple Domains-1 (CSMD1) protein is a tumour suppressor which has been shown to play a role in regulating human mammary duct development in vitro. CSMD1 knockdown in vitro demonstrated increased cell proliferation, invasion and motility. However, the role of Csmd1 in vivo is poorly characterised when it comes to ductal development and is therefore an area which warrants further exploration. In this study a Csmd1 knockout (KO) mouse model was used to identify the role of Csmd1 in regulating mammary gland development during puberty. Changes in duct development and protein expression patterns were analysed by immunohistochemistry. This study identified increased ductal development during the early stages of puberty in the KO mice, characterised by increased ductal area and terminal end bud number at 6 weeks. Furthermore, increased expression of various proteins (Stat1, Fak, Akt, Slug/Snail and Progesterone receptor) was shown at 4 weeks in the KO mice, followed by lower expression levels from 6 weeks in the KO mice compared to the wild type mice. This study identifies a novel role for Csmd1 in mammary gland development, with Csmd1 KO causing significantly more rapid mammary gland development, suggesting an earlier adult mammary gland formation.

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