scholarly journals Scabrous overexpression in the eye affects R3/R4 cell fate specification and inhibits notch signaling

2015 ◽  
Vol 245 (2) ◽  
pp. 166-174 ◽  
Author(s):  
Verónica Muñoz-Soriano ◽  
Diego Santos ◽  
Fabrice C. Durupt ◽  
Sandra Casani ◽  
Nuria Paricio
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification

scholarly journals RBP-Jκ-Dependent Notch Signaling Is Dispensable for Mouse Early Embryonic Development

2006 ◽  
Vol 26 (13) ◽  
pp. 4769-4774 ◽  
Author(s):  
Céline Souilhol ◽  
Sarah Cormier ◽  
Kenji Tanigaki ◽  
Charles Babinet ◽  
Michel Cohen-Tannoudji
Keyword(s):  
Embryonic Development ◽  
Notch Signaling ◽  
Signaling Pathway ◽  
Cell Fate ◽  
Notch Pathway ◽  
Notch Signaling Pathway ◽  
Preimplantation Embryos ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Evolutionarily Conserved

ABSTRACT The Notch signaling pathway is an evolutionarily conserved signaling system which has been shown to be essential in cell fate specification and in numerous aspects of embryonic development in all metazoans thus far studied. We recently demonstrated that several components of the Notch signaling pathway, including the four Notch receptors and their five ligands known in mammals, are expressed in mouse oocytes, in mouse preimplantation embryos, or both. This suggested a possible implication of the Notch pathway in the first cell fate specification of the dividing mouse embryo, which results in the formation of the blastocyst. To address this issue directly, we generated zygotes in which both the maternal and the zygotic expression of Rbpsuh, a key element of the core Notch signaling pathway, were abrogated. We find that such zygotes give rise to blastocysts which implant and develop normally. Nevertheless, after gastrulation, these embryos die around midgestation, similarly to Rbpsuh-null mutants. This demonstrates that the RBP-Jκ-dependent pathway, otherwise called the canonical Notch pathway, is dispensable for blastocyst morphogenesis and the establishment of the three germ layers, ectoderm, endoderm, and mesoderm. These results are discussed in the light of recent observations which have challenged this conclusion.

scholarly journals Transgenic Expression of Numb Inhibits Notch Signaling in Immature Thymocytes But Does Not Alter T Cell Fate Specification

2002 ◽  
Vol 168 (7) ◽  
pp. 3173-3180 ◽  
Author(s):  
Michelle B. French ◽  
Ute Koch ◽  
Rachel E. Shaye ◽  
Melanie A. McGill ◽  
Sascha E. Dho ◽  
...  
Keyword(s):  
T Cell ◽  
Notch Signaling ◽  
Cell Fate ◽  
Cell Fate Specification ◽  
Transgenic Expression ◽  
Fate Specification ◽  
Immature Thymocytes

scholarly journals Hes5.9 Coordinate FGF and Notch Signaling to Modulate Gastrulation via Regulating Cell Fate Specification and Cell Migration in Xenopus tropicalis

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1363
Author(s):  
Xiao Huang ◽  
Liyue Zhang ◽  
Shanshan Yang ◽  
Yongpu Zhang ◽  
Mingjiang Wu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Notch Signaling ◽  
Signaling Pathways ◽  
Cell Fate ◽  
Expression Patterns ◽  
Marker Genes ◽  
Cell Fate Specification ◽  
Mesodermal Cell ◽  
Cell Fate Decisions ◽  
Fate Specification

Gastrulation drives the establishment of three germ layers and embryonic axes during frog embryonic development. Mesodermal cell fate specification and morphogenetic movements are vital factors coordinating gastrulation, which are regulated by numerous signaling pathways, such as the Wnt (Wingless/Integrated), Notch, and FGF (Fibroblast growth factor) pathways. However, the coordination of the Notch and FGF signaling pathways during gastrulation remains unclear. We identified a novel helix–loop–helix DNA binding domain gene (Hes5.9), which was regulated by the FGF and Notch signaling pathways during gastrulation. Furthermore, gain- and loss-of-function of Hes5.9 led to defective cell migration and disturbed the expression patterns of mesodermal and endodermal marker genes, thus interfering with gastrulation. Collectively, these results suggest that Hes5.9 plays a crucial role in cell fate decisions and cell migration during gastrulation, which is modulated by the FGF and Notch signaling pathways.

scholarly journals Notch Signaling Alters Sensory or Neuronal Cell Fate Specification of Inner Ear Stem Cells

2011 ◽  
Vol 31 (23) ◽  
pp. 8351-8358 ◽  
Author(s):  
S.-J. Jeon ◽  
M. Fujioka ◽  
S.-C. Kim ◽  
A. S. B. Edge
Keyword(s):  
Stem Cells ◽  
Notch Signaling ◽  
Inner Ear ◽  
Cell Fate ◽  
Neuronal Cell ◽  
Cell Fate Specification ◽  
Fate Specification

Sox proteins: regulators of cell fate specification and differentiation

Development ◽  
2013 ◽  
Vol 140 (20) ◽  
pp. 4129-4144 ◽  
Author(s):  
Y. Kamachi ◽  
H. Kondoh
Keyword(s):  
Cell Fate ◽  
Cell Fate Specification ◽  
Fate Specification ◽  
Sox Proteins
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