scholarly journals Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis

2014 ◽  
Vol 244 (2) ◽  
pp. 122-133 ◽  
Author(s):  
Cynthia R. Hill ◽  
Britni H. Jacobs ◽  
Christopher B. Brown ◽  
Joey V. Barnett ◽  
Steven L. Goudy
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Type Iii ◽  
Beta Receptor ◽  
Osteoblast Development ◽  
Growth Factor Beta

scholarly journals Reduced expression of transforming growth factor-beta receptor type III in high stage neuroblastomas

2000 ◽  
Vol 82 (6) ◽  
pp. 1171-1176 ◽  
Author(s):  
A Iolascon ◽  
L Giordani ◽  
A Borriello ◽  
R Carbone ◽  
A Izzo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Receptor Type ◽  
Type Iii ◽  
Beta Receptor ◽  
High Stage ◽  
Growth Factor Beta

Osteoinductive effect of soluble transforming growth factor beta receptor 3 on human osteoblast lineage

2021 ◽  
Author(s):  
Angelica Mastandrea Amanso ◽  
Archana Kamalakar ◽  
Sara Bitarafan ◽  
Shelly Abramowicz ◽  
Hicham Drissi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Human Osteoblast ◽  
Beta Receptor ◽  
Growth Factor Beta ◽  
Osteoblast Lineage

Structure and Polymorphism Analysis of Transforming Growth Factor Beta Receptor 1 (TGFBR1) in Pigs

2005 ◽  
Vol 43 (9-10) ◽  
pp. 491-500 ◽  
Author(s):  
Shin-ichi Shimanuki ◽  
Ayumi Mikawa ◽  
Yuko Miyake ◽  
Noriyuki Hamasima ◽  
Satoshi Mikawa ◽  
...  
Keyword(s):  
Growth Factor ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Polymorphism Analysis ◽  
Beta Receptor ◽  
Growth Factor Beta

scholarly journals Novel Transforming Growth Factor-Beta Receptor 1 Antagonists through a Pharmacophore-Based Virtual Screening Approach

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2824 ◽  
Author(s):  
Junhao Jiang ◽  
Hui Zhou ◽  
Qihua Jiang ◽  
Lili Sun ◽  
Ping Deng
Keyword(s):  
Growth Factor ◽  
Virtual Screening ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Malignant Tumors ◽  
Pharmacophore Model ◽  
New Drugs ◽  
Beta Receptor ◽  
Potential Activity ◽  
Growth Factor Beta

As new drugs for the treatment of malignant tumors, transforming growth factor-beta receptor 1 (TGFβR1) antagonists have attracted wide attention. Based on the crystal structure of TGFβR1-BMS22 complex, the pharmacophore model A02 with two hydrogen bond acceptors (HBAs) and four hydrophobic (HYD) properties was constructed. From the common features of active ligands reported in the literature, pharmacophore model B10 was also generated, which has two aromatic ring centers (RAs) and two HYD properties. The two models have high sensitivity and specificity to the training set, and they are highly consistent in spatial structure. Combining the two pharmacophore models, two novel skeleton structures with potential activity were selected by virtual screening from the DruglikeDiverse, MiniMaybridge, and ZINC Drug-Like databases. Four compounds (YXY01–YXY04) with potential anti-TGFβR1 activity were designed based on the new skeleton structures. In combination with Lipinski’s rules; absorption, distribution, metabolism, excretion, and toxicity (ADMET); and, toxicological properties predicted in the study, YXY01-03 with the novel skeleton, good drug-like properties, and potential activity were finally discovered and may have higher safety relative to BMS22, which may be valuable for further research.

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