scholarly journals The homeodomain transcription factor PITX2 is required for specifying correct cell fates and establishing angiogenic privilege in the developing cornea

2014 ◽  
Vol 243 (11) ◽  
pp. 1391-1400 ◽  
Author(s):  
Philip J. Gage ◽  
Chen Kuang ◽  
Amanda L. Zacharias
Keyword(s):  
Transcription Factor ◽  
Cell Fates ◽  
Homeodomain Transcription Factor

Sibling cell fate in the Drosophila adult external sense organ lineage is specified by prospero function, which is regulated by Numb and Notch

Development ◽  
1999 ◽  
Vol 126 (10) ◽  
pp. 2083-2092 ◽  
Author(s):  
G.V. Reddy ◽  
V. Rodrigues
Keyword(s):  
Transcription Factor ◽  
Notch Signaling ◽  
Cell Fate ◽  
Sense Organ ◽  
Sensory Organ ◽  
Sensory Organs ◽  
Cell Fates ◽  
Homeodomain Transcription Factor ◽  
Intrinsic Signal ◽  
Sensory Organ Precursors

Specification of cell fate in the adult sensory organs is known to be dependent on intrinsic and extrinsic signals. We show that the homeodomain transcription factor Prospero (Pros) acts as an intrinsic signal for the specification of cell fates within the mechanosensory lineage. The sensory organ precursors divide to give rise to two secondary progenitors - PIIa and PIIb. Pros is expressed in PIIb, which gives rise to the neuron and thecogen cells. Loss of Pros function affects the identity of PIIb and neurons fail to differentiate. Pros misexpression is sufficient for the transformation of PIIa to PIIb fate. The expression of Pros in the normal PIIb cell appears to be regulated by Notch signaling.

scholarly journals A crucial role for the homeodomain transcription factor Hhex in lymphopoiesis

Blood ◽  
2015 ◽  
Vol 125 (5) ◽  
pp. 803-814 ◽  
Author(s):  
Jacob T. Jackson ◽  
Chayanica Nasa ◽  
Wei Shi ◽  
Nicholas D. Huntington ◽  
Clifford W. Bogue ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Crucial Role ◽  
Homeodomain Transcription Factor ◽  
Key Points

Key Points Hhex regulates development of diverse lymphoid lineages. Hhex regulates cycling of lymphoid precursors.

scholarly journals The PDX1 Homeodomain Transcription Factor Negatively Regulates the Pancreatic Ductal Cell-specific Keratin 19 Promoter

2006 ◽  
Vol 281 (50) ◽  
pp. 38385-38395 ◽  
Author(s):  
Therese B. Deramaudt ◽  
Mira M. Sachdeva ◽  
Melanie P. Wescott ◽  
Yuting Chen ◽  
Doris A. Stoffers ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Homeodomain Transcription Factor ◽  
Keratin 19 ◽  
Ductal Cell ◽  
Pancreatic Ductal Cell

Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1

FEBS Letters ◽  
1999 ◽  
Vol 461 (3) ◽  
pp. 229-234 ◽  
Author(s):  
Tilo Moede ◽  
Barbara Leibiger ◽  
Hamedeh Ghanaat Pour ◽  
Per-Olof Berggren ◽  
Ingo B Leibiger
Keyword(s):  
Transcription Factor ◽  
Nuclear Localization ◽  
Nuclear Localization Signal ◽  
Homeodomain Transcription Factor ◽  
Localization Signal

scholarly journals The Repo Homeodomain Transcription Factor Suppresses Hematopoiesis in Drosophila and Preserves the Glial Fate

2018 ◽  
Vol 39 (2) ◽  
pp. 238-255 ◽  
Author(s):  
Guillaume Trébuchet ◽  
Pierre B. Cattenoz ◽  
János Zsámboki ◽  
David Mazaud ◽  
Daria E. Siekhaus ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Homeodomain Transcription Factor ◽  
Glial Fate

Conservation of Pitx1 expression during amphibian limb morphogenesis

2006 ◽  
Vol 84 (2) ◽  
pp. 257-262 ◽  
Author(s):  
W Y Chang ◽  
F KhosrowShahian ◽  
M Wolanski ◽  
R Marshall ◽  
W McCormick ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Xenopus Laevis ◽  
Expression Patterns ◽  
Limb Bud ◽  
Eleutherodactylus Coqui ◽  
Limb Buds ◽  
Homeodomain Transcription Factor ◽  
Limb Morphogenesis ◽  
Pelvic Limb

In contrast to the pattern of limb emergence in mammals, chicks, and the newt N. viridescens, embryos such as Xenopus laevis and Eleutherodactylus coqui initiate pelvic limb buds before they develop pectoral ones. We studied the expression of Pitx1 in X. laevis and E. coqui to determine if this paired-like homeodomain transcription factor directs differentiation specifically of the hindlimb, or if it directs the second pair of limbs to form, namely the forelimbs. We also undertook to determine if embryonic expression patterns were recapitulated during the regeneration of an amputated limb bud. Pitx1 is expressed in hindlimbs in both X. laevis and E. coqui, and expression is similar in both developing and regenerating limb buds. Expression in hindlimbs is restricted to regions of proliferating mesenchyme.Key words: regeneration, Xenopus laevis, limb bud, Pitx1 protein, specification.

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