A Notch-dependent transcriptional hierarchy promotes mesenchymal transdifferentiation in the cardiac cushion

2014 ◽  
Vol 243 (7) ◽  
pp. 894-905 ◽  
Author(s):  
Alex C.Y. Chang ◽  
Victoria C. Garside ◽  
Michele Fournier ◽  
Justin Smrz ◽  
Pavle Vrljicak ◽  
...  
Keyword(s):  
Cardiac Cushion

Endocytic activity in embryonic cardiac cushion mesenchyme in vivo and in collagen gel lattices

1983 ◽  
Vol 205 (3) ◽  
pp. 331-346 ◽  
Author(s):  
Don A. Hay ◽  
Roger R. Markwald ◽  
Alexis P. Sage
Keyword(s):  
Collagen Gel ◽  
Cardiac Cushion ◽  
Endocytic Activity

scholarly journals Frzb modulates Wnt-9a-mediated β-catenin signaling during avian atrioventricular cardiac cushion development

2005 ◽  
Vol 278 (1) ◽  
pp. 35-48 ◽  
Author(s):  
Anthony D. Person ◽  
Robert J. Garriock ◽  
Paul A. Krieg ◽  
Raymond B. Runyan ◽  
Scott E. Klewer
Keyword(s):  
Cardiac Cushion

scholarly journals Proteolytic cleavage of versican during cardiac cushion morphogenesis

2006 ◽  
Vol 235 (8) ◽  
pp. 2238-2247 ◽  
Author(s):  
Christine B. Kern ◽  
Waleed O. Twal ◽  
Corey H. Mjaatvedt ◽  
Sarah E. Fairey ◽  
Bryan P. Toole ◽  
...  
Keyword(s):  
Proteolytic Cleavage ◽  
Cardiac Cushion

scholarly journals Observation of the abluminal surface of the atrioventricular endothelium which undergoes transition into cardiac cushion mesenchymal cells in the chick embryo.

2000 ◽  
Vol 42 (3) ◽  
pp. 169-175
Author(s):  
Keiko Iwakami ◽  
Keitaro Isokawa ◽  
Hitomi Sejima ◽  
Osamu Shimizu ◽  
Tamotsu Morikawa ◽  
...  
Keyword(s):  
Chick Embryo ◽  
Mesenchymal Cells ◽  
Cardiac Cushion

ErbB3 is required for normal cerebellar and cardiac development: a comparison with ErbB2-and heregulin-deficient mice

Development ◽  
1997 ◽  
Vol 124 (24) ◽  
pp. 4999-5011 ◽  
Author(s):  
S.L. Erickson ◽  
K.S. O'Shea ◽  
N. Ghaboosi ◽  
L. Loverro ◽  
G. Frantz ◽  
...  
Keyword(s):  
Chromaffin Cells ◽  
Cardiac Development ◽  
Enteric Ganglia ◽  
Erbb2 Receptor ◽  
Myocyte Differentiation ◽  
Development And Differentiation ◽  
Cranial Ganglia ◽  
Cardiac Cushion ◽  
Adrenal Chromaffin ◽  
Deficient Mice

Heregulins bind directly to ErbB3 and ErbB4 receptors, leading to multiple dimerization possibilities including heterodimerization with the ErbB2 receptor. We have generated ErbB3-, ErbB2- and heregulin-deficient mice to assess their roles in development and differentiation. Heregulin(−/−) and ErbB2(−/−) embryos died on E10.5 due to a lack of cardiac ventricular myocyte differentiation; ErbB3(−/−) embryos survived until E13.5 exhibiting cardiac cushion abnormalities leading to blood reflux through defective valves. In ErbB3(−/−) embryos, the midbrain/hindbrain region was strikingly affected, with little differentiation of the cerebellar plate. Cranial ganglia defects, while present in all three nulls, were less severe in ErbB3(−/−) embryos. The cranial ganglia defects, along with a dramatic reduction in Schwann cells, enteric ganglia and adrenal chromaffin cells, suggests a generalized effect on the neural crest. Numerous organs, including the stomach and pancreas also exhibited anomalous development.

scholarly journals Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation

2003 ◽  
Vol 258 (2) ◽  
pp. 252-263 ◽  
Author(s):  
Yukiko Sugi ◽  
Naoki Ito ◽  
Györgyi Szebenyi ◽  
Kioina Myers ◽  
John F Fallon ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Mesenchymal Cells ◽  
Valve Leaflet ◽  
Fibroblast Growth ◽  
Cardiac Cushion
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