scholarly journals Correct Timing of Proliferation and Differentiation is Necessary for Normal Inner Ear Development and Auditory Hair Cell Viability

2013 ◽  
Vol 242 (2) ◽  
pp. 132-147 ◽  
Author(s):  
Benjamin J. Kopecky ◽  
Israt Jahan ◽  
Bernd Fritzsch
Keyword(s):  
Cell Viability ◽  
Hair Cell ◽  
Inner Ear ◽  
Ear Development ◽  
Inner Ear Development ◽  
Proliferation And Differentiation

scholarly journals Applying genomics to the avian inner ear: Development of subtractive cDNA resources for exploring sensory function and hair cell regeneration

Genomics ◽  
2006 ◽  
Vol 87 (6) ◽  
pp. 801-808 ◽  
Author(s):  
R. David Hawkins ◽  
Cynthia A. Helms ◽  
Julia B. Winston ◽  
Mark E. Warchol ◽  
Michael Lovett
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Sensory Function ◽  
Cell Regeneration ◽  
Hair Cell Regeneration ◽  
Ear Development ◽  
Inner Ear Development ◽  
Avian Inner Ear

scholarly journals Fgf8 genetic labeling reveals the early specification of vestibular hair cell type in mouse utricle

Development ◽  
2020 ◽  
Vol 147 (22) ◽  
pp. dev192849
Author(s):  
Evan M. Ratzan ◽  
Anne M. Moon ◽  
Michael R. Deans
Keyword(s):  
Hair Cell ◽  
Inner Ear ◽  
Hair Cells ◽  
Conditional Knockout ◽  
Developmental Model ◽  
Type I ◽  
Ear Development ◽  
Inner Ear Development ◽  
Morphological Criteria ◽  
Genetic Labeling

ABSTRACTFGF8 signaling plays diverse roles in inner ear development, acting at multiple stages from otic placode induction to cellular differentiation in the organ of Corti. As a secreted morphogen with diverse functions, Fgf8 expression is likely to be spatially restricted and temporally dynamic throughout inner ear development. We evaluated these characteristics using genetic labeling mediated by Fgf8mcm gene-targeted mice and determined that Fgf8 expression is a specific and early marker of Type-I vestibular hair cell identity. Fgf8mcm expression initiates at E11.5 in the future striolar region of the utricle, labeling hair cells following EdU birthdating, and demonstrates that sub-type identity is determined shortly after terminal mitosis. This early fate specification is not apparent using markers or morphological criteria that are not present before birth in the mouse. Although analyses of Fgf8 conditional knockout mice did not reveal developmental phenotypes, the restricted pattern of Fgf8 expression suggests that functionally redundant FGF ligands may contribute to vestibular hair cell differentiation and supports a developmental model in which Type-I and Type-II hair cells develop in parallel rather than from an intermediate precursor.

Comparative analysis of conservation and regulatory network on core transcription factors in mouse inner ear development

2013 ◽  
Vol 35 (10) ◽  
pp. 1198-1208
Author(s):  
Zhi-Qiang CHEN ◽  
Xin-Huan HAN ◽  
Qin-Jun WEI ◽  
Guang-Qian XING ◽  
Xin CAO
Keyword(s):  
Transcription Factors ◽  
Comparative Analysis ◽  
Inner Ear ◽  
Regulatory Network ◽  
Ear Development ◽  
Inner Ear Development

scholarly journals Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice

2009 ◽  
Vol 328 (2) ◽  
pp. 328-341 ◽  
Author(s):  
Garrett A. Soukup ◽  
Bernd Fritzsch ◽  
Marsha L. Pierce ◽  
Michael D. Weston ◽  
Israt Jahan ◽  
...  
Keyword(s):  
Inner Ear ◽  
Knockout Mice ◽  
Microrna Expression ◽  
Ear Development ◽  
Inner Ear Development

scholarly journals Role of microRNAs in inner ear development and hearing loss

Gene ◽  
2019 ◽  
Vol 686 ◽  
pp. 49-55 ◽  
Author(s):  
Rahul Mittal ◽  
George Liu ◽  
Sai P. Polineni ◽  
Nicole Bencie ◽  
Denise Yan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Ear Development ◽  
Inner Ear Development
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