scholarly journals Thyroid hormone-induced sonic hedgehog signal up-regulates its own pathway in a paracrine manner in theXenopus laevisintestine during metamorphosis

2011 ◽  
Vol 241 (2) ◽  
pp. 403-414 ◽  
Author(s):  
Takashi Hasebe ◽  
Mitsuko Kajita ◽  
Liezhen Fu ◽  
Yun-Bo Shi ◽  
Atsuko Ishizuya-Oka
Keyword(s):  
Thyroid Hormone ◽  
Sonic Hedgehog ◽  
Hedgehog Signal

scholarly journals Early Palaeozoic dentine and patterned scales in the embryonic catshark tail

2007 ◽  
Vol 4 (1) ◽  
pp. 87-90 ◽  
Author(s):  
Zerina Johanson ◽  
Mikiko Tanaka ◽  
Natalie Chaplin ◽  
Moya Smith
Keyword(s):  
Scale Development ◽  
Sonic Hedgehog ◽  
The Body ◽  
Iterative Sequence ◽  
Histological Structure ◽  
Scyliorhinus Canicula ◽  
Pulp Cavity ◽  
Early Palaeozoic ◽  
Hedgehog Signal ◽  
Modular Nature

Regular scale patterning, restricted to the caudalmost tail and organized into two opposing rows on each side of the tail, is observed in few chondrichthyans. These evenly spaced scales, in dorsal and ventral rows, develop in an iterative sequence from the caudal tip, either side of the notochord. They are subsequently lost as a scattered pattern of placoid scales develops on the body and fins. An identical organized pattern is observed in tail scales of Scyliorhinus canicula (catshark), where the expression of sonic hedgehog signal is restricted to the epithelium of developing scales and remains localized to the scale pocket. Regulation of iterative scale position by sonic hedgehog is deeply conserved in vertebrate phylogeny. These scales also reveal an archaic histological structure of a dentine type found in the oldest known shark scales from the Ordovician and Silurian. This combination of regulated pattern and ancient dentine occurs only in the tail, representing the primary scalation. Scattered body scales in elasmobranchs such as S. canicula originate secondarily from differently regulated development, one with typical orthodentine around a central pulp cavity. These observations emphasize the modular nature of chondrichthyan scale development and illustrate previously undetected variation as an atavism in extant chondrichthyan dentine.

Imaging of the Ciliary Cholesterol Underlying the Sonic Hedgehog Signal Transduction

2021 ◽  
pp. 49-57
Author(s):  
Tatsuo Miyamoto ◽  
Kosuke Hosoba ◽  
Silvia Natsuko Akutsu ◽  
Shinya Matsuura
Keyword(s):  
Signal Transduction ◽  
Sonic Hedgehog ◽  
Hedgehog Signal Transduction ◽  
Hedgehog Signal

scholarly journals Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

eLife ◽  
2014 ◽  
Vol 3 ◽  
Author(s):  
Shen Yue ◽  
Liu-Ya Tang ◽  
Ying Tang ◽  
Yi Tang ◽  
Qiu-Hong Shen ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Feedback Loop ◽  
Hect Domain ◽  
E3 Ligases ◽  
Caveolin 1 ◽  
Shh Pathway ◽  
Sorting Signals ◽  
Pathway Activation ◽  
Endocytic Sorting ◽  
Hedgehog Signal

Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development. Here, we report endocytic sorting signals for the receptor Patched1 (Ptch1), comprising two ‘PPXY’ motifs, that direct it to degradation in lysosomes. These signals are recognized by two HECT-domain ubiquitin E3 ligases, Smurf1 and Smurf2, which are induced by Shh and become enriched in Caveolin-1 lipid rafts in association with Ptch1. Smurf-mediated endocytic turnover of Ptch1 is essential for its clearance from the primary cilium and pathway activation. Removal of both Smurfs completely abolishes the ability of Shh to sustain the proliferation of postnatal granule cell precursors in the cerebellum. These findings reveal a novel step in the Shh pathway activation as part of the Ptch1 negative feedback loop that precisely controls the signaling output in response to Shh gradient signal.

scholarly journals MBRS-32. TOPOISOMERASE II β INDUCES NEURONAL, BUT NOT GLIAL, DIFFERENTIATION IN MEDULLOBLASTOMA

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii404-iii404
Author(s):  
Hiroaki Miyahara ◽  
Manabu Natsumeda ◽  
Junichi Yoshimura ◽  
Yukihiko Fujii ◽  
Akiyoshi Kakita ◽  
...  
Keyword(s):  
Histone Modification ◽  
Neuronal Differentiation ◽  
Sonic Hedgehog ◽  
Topoisomerase Ii ◽  
Therapeutic Targets ◽  
Glial Differentiation ◽  
Favorable Prognosis ◽  
Differentiated Cells ◽  
Histone Modification Enzymes ◽  
Hedgehog Signal

Abstract BACKGROUND We previously reported that Gli3, which was a downstream molecule of Sonic Hedgehog signal, induced neuronal and/or glial differentiation in some types of medulloblastoma (desmoplastic/nodular medulloblastoma and medulloblastoma with extensive nodularity), and patients of medulloblastoma with neuronal differentiation showed favorable prognosis, but those with glial differentiation tended to show miserable prognosis (Miyahara H, Neuropathology, 2013). This time, we focused on Topoisomerase II β (Top2β), which was reported to induce neuronal differentiation and inhibit glial differentiation, and examined the expression of Top2β in medulloblastomas with neuronal and glial differentiations. METHODS We assessed the expression of Top2β, NeuN, and GFAP using triple fluorescent immunostaining method in medulloblastoma samples with both neuronal and glial differentiations. Furthermore, the expression of Top2β, H3K4me2, and H3K27me3 were also assessed, because Top2βwas positively or negatively regulated by H3K4me2 and H3K27me3, respectively. RESULTS Many large nuclei in the nodules, in which differentiated cells were seen, was visualized by Top2β. The Top2β signals were seen in NeuN+ cells but not GFAP+ cells. H3K4me2 signals were visualized in Top2β+ large nuclei, but H3K27me3 and NeuN+ large nuclei were distributed independently. CONCLUSIONS These results indicate that Top2β may be a molecule associated with neuronal, but not glial, differentiation of medulloblastoma cells. Drugs targeting histone modification enzymes such as EZH2 inhibitors are possible therapeutic targets as a differentiation-inducing therapy for medulloblastoma.

Sonic hedgehog signal peptide mutation in a patient with holoprosencephaly

2000 ◽  
Vol 47 (4) ◽  
pp. 514-516 ◽  
Author(s):  
Mitsuhiro Kato ◽  
Eiji Nanba ◽  
Shinjiro Akaboshi ◽  
Takashi Shiihara ◽  
Aiko Ito ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Signal Peptide ◽  
Hedgehog Signal

scholarly journals New Insights into Development of Female Reproductive Tract—Hedgehog-Signal Response in Wolffian Tissues Directly Contributes to Uterus Development

2021 ◽  
Vol 22 (3) ◽  
pp. 1211
Author(s):  
Ryuma Haraguchi ◽  
Gen Yamada ◽  
Aki Murashima ◽  
Daisuke Matsumaru ◽  
Riko Kitazawa ◽  
...  
Keyword(s):  
Sonic Hedgehog ◽  
Cell Tracking ◽  
Reproductive Tract ◽  
Female Reproductive Tract ◽  
Mouse Uterus ◽  
Uterine Growth ◽  
Mullerian Ducts ◽  
Radial Axis ◽  
Hedgehog Signal

The reproductive tract in mammals emerges from two ductal systems during embryogenesis: Wolffian ducts (WDs) and Mullerian ducts (MDs). Most of the female reproductive tract (FRT) including the oviducts, uterine horn and cervix, originate from MDs. It is widely accepted that the formation of MDs depends on the preformed WDs within the urogenital primordia. Here, we found that the WD mesenchyme under the regulation of Hedgehog (Hh) signaling is closely related to the developmental processes of the FRT during embryonic and postnatal periods. Deficiency of Sonic hedgehog (Shh), the only Hh ligand expressed exclusively in WDs, prevents the MD mesenchyme from affecting uterine growth along the radial axis. The in vivo cell tracking approach revealed that after WD regression, distinct cells responding to WD-derived Hh signal continue to exist in the developing FRT and gradually contribute to the formation of various tissues such as smooth muscle, endometrial stroma and vascular vessel, in the mouse uterus. Our study thus provides a novel developmental mechanism of FRT relying on WD.

Sign in / Sign up

Export Citation Format

Share Document