scholarly journals Cell polarity and spindle orientation in the distal epithelium of embryonic lung

2011 ◽  
Vol 240 (2) ◽  
pp. 441-445 ◽  
Author(s):  
Ahmed H. El-Hashash ◽  
David Warburton
Keyword(s):  
Cell Polarity ◽  
Spindle Orientation ◽  
Embryonic Lung

scholarly journals Retraction: Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium. Development doi: 10.1242/dev.058479

Development ◽  
2017 ◽  
Vol 144 (20) ◽  
pp. 3849-3849 ◽  
Author(s):  
Ahmed HK El-Hashash ◽  
Gianluca Turcatel ◽  
Denise Al Alam ◽  
Sue Buckley ◽  
Hiroshi Tokumitsu ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Cell Polarity ◽  
Spindle Orientation ◽  
Embryonic Lung ◽  
Lung Epithelium

scholarly journals Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium

Development ◽  
2011 ◽  
Vol 138 (7) ◽  
pp. 1395-1407 ◽  
Author(s):  
Ahmed HK El-Hashash ◽  
Gianluca Turcatel ◽  
Denise Al Alam ◽  
Sue Buckley ◽  
Hiroshi Tokumitsu ◽  
...  
Keyword(s):  
Notch Signaling ◽  
Cell Fate ◽  
Cell Polarity ◽  
Spindle Orientation ◽  
Embryonic Lung ◽  
Lung Epithelium

Cortical Cyclin A controls spindle orientation during asymmetric cell division

2021 ◽  
Author(s):  
Pénélope Darnat ◽  
Angelique Burg ◽  
Jérémy Sallé ◽  
Jérôme Lacoste ◽  
Sophie Louvet-Vallée ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Polarity ◽  
Cell Cycle Progression ◽  
Planar Cell Polarity ◽  
Asymmetric Cell Division ◽  
Cyclin A ◽  
Spindle Orientation ◽  
Posterior Cortex ◽  
Cell Diversity

Abstract Cell proliferation and cell polarity need to be precisely coordinated to orient the asymmetric cell divisions crucial for generating cell diversity in epithelia. In many instances, the Frizzled/Dishevelled planar cell polarity pathway is involved in mitotic spindle orientation, but how this is spatially and temporally coordinated with cell cycle progression has remained elusive. Using Drosophila sensory organ precursor cells as a model system, we show that Cyclin A, the main Cyclin driving the transition to M-phase of the cell cycle, is recruited to the apical-posterior cortex in prophase by the Frizzled/Dishevelled complex. This cortically localized Cyclin A then regulates the orientation of the division by recruiting Mud, a homologue of NuMA, the well-known spindle-associated protein. The observed non-canonical subcellular localization of Cyclin A reveals this mitotic factor as a direct link between cell proliferation, cell polarity and spindle orientation.

scholarly journals Cytokine receptor-Eb1 interaction couples cell polarity and fate during asymmetric cell division

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Cuie Chen ◽  
Ryan Cummings ◽  
Aghapi Mordovanakis ◽  
Alan J Hunt ◽  
Michael Mayer ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Division ◽  
Cell Fate ◽  
Cell Polarity ◽  
Adult Stem Cells ◽  
Asymmetric Cell Division ◽  
Cytokine Receptor ◽  
Spindle Orientation ◽  
Germline Stem Cells ◽  
Self Renewal

Asymmetric stem cell division is a critical mechanism for balancing self-renewal and differentiation. Adult stem cells often orient their mitotic spindle to place one daughter inside the niche and the other outside of it to achieve asymmetric division. It remains unknown whether and how the niche may direct division orientation. Here we discover a novel and evolutionary conserved mechanism that couples cell polarity to cell fate. We show that the cytokine receptor homolog Dome, acting downstream of the niche-derived ligand Upd, directly binds to the microtubule-binding protein Eb1 to regulate spindle orientation in Drosophila male germline stem cells (GSCs). Dome’s role in spindle orientation is entirely separable from its known function in self-renewal mediated by the JAK-STAT pathway. We propose that integration of two functions (cell polarity and fate) in a single receptor is a key mechanism to ensure an asymmetric outcome following cell division.

scholarly journals CDC-42 controls early cell polarity and spindle orientation in C. elegans

2001 ◽  
Vol 11 (7) ◽  
pp. 482-488 ◽  
Author(s):  
Monica Gotta ◽  
Mary C. Abraham ◽  
Julie Ahringer
Keyword(s):  
Cell Polarity ◽  
Spindle Orientation ◽  
C Elegans
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