Characterization of Pitx2c expression in the mouse heart using a reporter transgene

2010 ◽  
Vol 240 (1) ◽  
pp. 195-203 ◽  
Author(s):  
Milena B. Furtado ◽  
Christine Biben ◽  
Hidetaka Shiratori ◽  
Hiroshi Hamada ◽  
Richard P. Harvey
Keyword(s):  
Mouse Heart ◽  
Reporter Transgene

scholarly journals Characterization of ClC‐2 Chloride Channel/PKA Interaction in Mouse Heart

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Zheng Maggie Huang ◽  
Fiona Britton ◽  
Can Yuan ◽  
Changlong An ◽  
William Hatton ◽  
...  
Keyword(s):  
Chloride Channel ◽  
Mouse Heart

scholarly journals Characterization of dynamic gene networks in response to thoracotomy, ischemia-reperfusion in mouse heart

2019 ◽  
Vol 11 (2) ◽  
pp. 215
Author(s):  
S. Badawi ◽  
B. Pillot ◽  
L. Augeul ◽  
M. Ovize ◽  
M. Kurdi ◽  
...  
Keyword(s):  
Gene Networks ◽  
Ischemia Reperfusion ◽  
Mouse Heart

Characterization of Fibroblast Growth Factor Receptor 1 RNA Expression in the Embryonic Mouse Heart

1995 ◽  
Vol 752 (1 Cardiac Growt) ◽  
pp. 406-416 ◽  
Author(s):  
KISHORE B. S. PASUMARTHI ◽  
YAN JIN ◽  
MARGARET E. BOCK ◽  
ARISTIDES LYTRAS ◽  
ELISSAVET KARDAMI ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Mouse Heart ◽  
Rna Expression ◽  
Fibroblast Growth ◽  
Embryonic Mouse

scholarly journals Characterization of the ER -/-mouse heart

2004 ◽  
Vol 101 (39) ◽  
pp. 14234-14239 ◽  
Author(s):  
C. Forster ◽  
S. Kietz ◽  
K. Hultenby ◽  
M. Warner ◽  
J.-A. Gustafsson
Keyword(s):  
Mouse Heart

Characterization of βARKct engineered extracellular vesicles and model specific cardioprotection

2021 ◽  
Author(s):  
Jin-Sook Kwon ◽  
Sarah M Schumacher ◽  
Erhe Gao ◽  
J Kurt Chuprun ◽  
Jessica Ibetti ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Mouse Heart ◽  
Receptor Kinase ◽  
Embryonic Fibroblasts ◽  
Induced Apoptosis ◽  
And Control ◽  
G Protein Coupled

Recent data supporting any benefit of stem cell therapy for ischemic heart disease has suggested paracrine-based mechanisms via extracellular vesicles (EVs) including exosomes. We have previously engineered cardiac-derived progenitor cell (CDC) to express a peptide inhibitor, βARKct, of G protein-coupled receptor kinase 2, leading to improvements in cell proliferation, survival and metabolism. In this study we tested whether βARKct-CDC EVs would be efficacious when applied to stressed myocytes in vitro and in vivo. When isolated EVs from βARKct-CDC and control GFP-CDC were added to cardiomyocytes in culture, they both protected against hypoxia-induced apoptosis. We tested whether these EVs could protect the mouse heart in vivo following exposure either to myocardial infarction (MI) or acute catecholamine toxicity. Both types of EVs significantly protected against ischemic injury and improved cardiac function after MI compared to mice treated with EVs from mouse embryonic fibroblasts, however βARKct EVs treated mice did display some unique beneficial properties including significantly altered pro- and anti-inflammatory cytokines. Importantly, in a catecholamine toxicity model of heart failure (HF), myocardial injections of βARKct-containing EVs were superior at preventing HF compared to control EVs and this catecholamine toxicity protection was recapitulated in vitro. Therefore, introduction of the βARKct into cellular EVs can have improved reparative properties in the heart especially against catecholamine damage, which is significant since sympathetic nervous system activity is increased in HF.

Characterization of dynamic gene networks of control ischemic reperfused mouse heart

2018 ◽  
Vol 120 ◽  
pp. 44
Author(s):  
S. Badawi ◽  
M. Ovize ◽  
L. Augeul ◽  
B. Pillot ◽  
M. Kurdi ◽  
...  
Keyword(s):  
Gene Networks ◽  
Mouse Heart

scholarly journals Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development

2007 ◽  
Vol 54 (3,4) ◽  
pp. 276-288 ◽  
Author(s):  
Yuka Takehara-Kasamatsu ◽  
Kunihiro Tsuchida ◽  
Masashi Nakatani ◽  
Tatsuya Murakami ◽  
Akira Kurisaki ◽  
...  
Keyword(s):  
Heart Development ◽  
Family Members ◽  
Mouse Heart ◽  
Related Gene ◽  
Regulatory Factor ◽  
Negative Regulatory Factor
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