Origin and fate of cardiac mesenchyme

Brian S. Snarr; Christine B. Kern; Andy Wessels

doi:10.1002/dvdy.21725

Mechanisms of epibolic tissue spreading analyzed in a model morphogenetic system. Roles for cell migration and tissue contractility

Journal of Cell Science ◽

10.1242/jcs.102.2.373 ◽

1992 ◽

Vol 102 (2) ◽

pp. 373-385 ◽

Cited By ~ 1

Author(s):

M.T. Armstrong ◽

P.B. Armstrong

Keyword(s):

Extracellular Matrix ◽

Chick Embryo ◽

Epithelial Tissue ◽

Cortical Cells ◽

Culture Model ◽

Retinal Epithelium ◽

Core Tissue ◽

Mesenchyme Cells ◽

Cardiac Mesenchyme ◽

System 1

The processes responsible for epithelial spreading during wound healing and embryonic morphogenesis were investigated in an organ culture model in which an epithelial tissue (chick embryo pigmented retinal epithelium) spread over the surface of an aggregate of mesenchyme cells (chick embryo cardiac mesenchyme). The heart mesenchyme aggregate is differentiated into a core of stellate cells associated with a fibronectin-poor matrix surrounded by a cortical zone, 2–5 cells in thickness, of flattened cells embedded in a fibronectin-rich extracellular matrix. Envelopment of the mesenchyme aggregate is accompanied by a movement of the cells and the fibronectin-rich extracellular matrix of the cortex over the core tissue in advance of the spreading pigmented retina tissue. Three distinct processes were identified as contributing to epithelial spreading in this system: (1) active migration of the pigmented retinal epithelium; (2) active contraction of the cortical cells of the mesenchyme aggregate to tow the attached epithelial tissue over the mesenchyme aggregate; and (3) ingression of surface-located cells of the mesenchyme aggregate to decrease the exposed surface area by decreasing the number of cells at the surface.

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Identification of a 283-kDa Protein Component of the Particulate Matrix Associated with Cardiac Mesenchyme Formation

Cells Tissues Organs ◽

10.1159/000147810 ◽

1996 ◽

Vol 155 (4) ◽

pp. 219-230 ◽

Cited By ~ 12

Author(s):

A.R. Sinning ◽

C.C. Hewitt

Keyword(s):

Protein Component ◽

Particulate Matrix ◽

Cardiac Mesenchyme

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The development of hepatogenic potency in the endoderm of quail embryos

Development ◽

10.1242/dev.52.1.49 ◽

1979 ◽

Vol 52 (1) ◽

pp. 49-62

Author(s):

Sumiko Fukuda

Keyword(s):

Digestive Tract ◽

The Other ◽

Chick Embryos ◽

Posterior Half ◽

Coelomic Cavity ◽

Somite Stage ◽

Anterior Half ◽

Other Hand ◽

Cardiac Region ◽

Cardiac Mesenchyme

Hepatogenic potency of the endoderm is detectable in the anterior half of the endoderm of quail embryos older than 2-somite stage when endodermal fragments are cultured with or without heterologous chick mesenchymes, in the coelomic cavity of 3-day chick embryos. On the other hand, the posterior half of the endoderm never has hepatogenic potency. The hepatogenic potency of the endoderm is gradually stabilised with increasing age. However, expression of hepatogenesis can be affected when the endoderm is associated with inductively active digestive tract mesenchymes. Mesenchyme taken from the presumptive cardiac region (‘cardiac’ mesenchyme) of chick embryos is necessary for the uncommitted anterior endoderm to acquire hepatogenic potency, and this effect is specific for the ‘cardiac’ mesenchyme. The ‘cardiac’ mesenchyme, however, fails to induce hepatic epithelium in the allantoic endoderm, which can differentiate heterotypically when cultured in combination with digestive tract mesenchymes. The evidence presented in this study suggests that the effect of ‘cardiac’ mesenchyme on the acquisition of hepatogenic potency in the endoderm is limited.

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