Retinoic acid down-regulates Tbx1 expression and induces abnormal differentiation of tongue muscles in fetal mice

2008 ◽  
Vol 237 (10) ◽  
pp. 3059-3070 ◽  
Author(s):  
Junko Okano ◽  
Yasuo Sakai ◽  
Kohei Shiota
Keyword(s):  
Retinoic Acid ◽  
Fetal Mice ◽  
Tongue Muscles ◽  
Tbx1 Expression

Developmental anomalies induced by all-trans retinoic acid in fetal mice: I. Macroscopic findings

Teratology ◽  
1986 ◽  
Vol 34 (1) ◽  
pp. 37-49 ◽  
Author(s):  
Yoshiko Yasuda ◽  
Masaharu Okamoto ◽  
Hiroyoshi Konishi ◽  
Takuya Matsuo ◽  
Takahide Kihara ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Developmental Anomalies ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Fetal Mice ◽  
Macroscopic Findings

Retinoic Acid Induces Myogenic Tongue Abnormalities in Fetal Mice

2015 ◽  
Vol 119 (3) ◽  
pp. e209
Author(s):  
Wei Cong ◽  
Bo Liu ◽  
Ru Wang ◽  
Jing Xiao
Keyword(s):  
Retinoic Acid ◽  
Fetal Mice

Retinoic acid alters EGF receptor expression during palatogenesis

Development ◽  
1988 ◽  
Vol 102 (4) ◽  
pp. 853-867 ◽  
Author(s):  
B.D. Abbott ◽  
E.D. Adamson ◽  
R.M. Pratt
Keyword(s):  
Cell Death ◽  
Retinoic Acid ◽  
Epithelial Cells ◽  
Programmed Cell Death ◽  
Egf Receptor ◽  
Receptor Expression ◽  
Egf Receptors ◽  
Receptor Localization ◽  
All Trans Retinoic Acid ◽  
Fetal Mice

Various growth factors are necessary for normal embryonic development and EGF receptors are present in developing palatal shelves of embryonic/fetal mice at least from day 12 of gestation. The medial epithelium of the palatal shelf undergoes a series of developmental events which do not occur in the oral and nasal epithelia. In utero and in organ culture, the control palatal medial epithelium shows a developmental decline in EGF receptors, demonstrated both by a decrease in the binding of antibody to EGF receptors and a decrease in the binding of 125I-EGF; decreases which are not observed in cells of the adjacent oral or nasal epithelium. During this period, medial cells cease DNA synthesis and undergo programmed cell death. Medial epithelial cells exposed to all-trans-retinoic acid continue to express EGF receptors, bind EGF, proliferate, fail to undergo programmed cell death and exhibit a morphology typical of nasal cells. The data suggest that this disturbance by retinoic acid of EGF receptor localization and subsequent alterations in differentiation of the epithelial cells plays a role in the retinoic-acid-mediated induction of cleft palate.

Developmental anomalies induced by all-trans-retinoic acid in fetal mice: II. Induction of abnormal neuroepithelium

Teratology ◽  
1987 ◽  
Vol 35 (3) ◽  
pp. 355-366 ◽  
Author(s):  
Yoshiko Yasuda ◽  
Hiroyoshi Konishi ◽  
Takahide Kihara ◽  
Takashi Tanimura
Keyword(s):  
Retinoic Acid ◽  
Developmental Anomalies ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Fetal Mice

Influence of retinoic acid on TBX1 expression in myocardial cells induced by Shh and Fgf8

2009 ◽  
Vol 3 (1) ◽  
pp. 61-66 ◽  
Author(s):  
Miao Liu ◽  
Xiaoyan Wu ◽  
Jiawei Xu ◽  
Runming Jin
Keyword(s):  
Retinoic Acid ◽  
Myocardial Cells ◽  
Tbx1 Expression
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