scholarly journals Zebrafishcdc25a is expressed during early development and limiting for post-blastoderm cell cycle progression

2007 ◽  
Vol 236 (12) ◽  
pp. 3427-3435 ◽  
Author(s):  
Damian E. Dalle Nogare ◽  
Andrea Arguello ◽  
Shelley Sazer ◽  
Mary Ellen Lane
Keyword(s):  
Cell Cycle ◽  
Early Development ◽  
Cell Cycle Progression ◽  
Cycle Progression ◽  
Blastoderm Cell

scholarly journals Aneuploidy during the onset of mouse embryo development

Reproduction ◽  
2020 ◽  
Vol 160 (5) ◽  
pp. 773-782
Author(s):  
Tereza Pauerova ◽  
Lenka Radonova ◽  
Kristina Kovacovicova ◽  
Lucia Novakova ◽  
Michal Skultety ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Early Development ◽  
Cell Cycle Progression ◽  
Developmental Stages ◽  
Model Organism ◽  
Cell Stage ◽  
Cycle Progression ◽  
Animal Reproduction ◽  
Cycle Arrest ◽  
Mouse Embryo Development

Aneuploidy is the most frequent single cause leading into the termination of early development in human and animal reproduction. Although the mouse is frequently used as a model organism for studying the aneuploidy, we have only incomplete information about the frequency of numerical chromosomal aberrations throughout development, usually limited to a particular stage or assumed from the occurrence of micronuclei. In our study, we systematically scored aneuploidy in in vivo mouse embryos, from zygotes up to 16-cell stage, using kinetochore counting assay. We show here that the frequency of aneuploidy per blastomere remains relatively similar from zygotes until 8-cell embryos and then increases in 16-cell embryos. Due to the accumulation of blastomeres, aneuploidy per embryo increases gradually during this developmental period. Our data also revealed that the aneuploidy from zygotes and 2-cell embryos does not propagate further into later developmental stages, suggesting that embryos suffering from aneuploidy are eliminated at this stage. Experiments with reconstituted live embryos revealed, that hyperploid blastomeres survive early development, although they exhibit slower cell cycle progression and suffer frequently from DNA fragmentation and cell cycle arrest.

1955-P: GLP-1R Activation Attenuates Prostate Cancer Growth via Inhibiting Cell Cycle Progression

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1955-P
Author(s):  
TORU SHIGEOKA ◽  
TAKASHI NOMIYAMA ◽  
TAKAKO KAWANAMI ◽  
YURIKO HAMAGUCHI ◽  
TOMOKO TANAKA ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Cycle Progression ◽  
Cancer Growth ◽  
Cycle Progression
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