Sox6 is required for normal fiber type differentiation of fetal skeletal muscle in mice

2007 ◽  
Vol 236 (8) ◽  
pp. 2062-2076 ◽  
Author(s):  
Nobuko Hagiwara ◽  
Michael Yeh ◽  
Ann Liu
Keyword(s):  
Skeletal Muscle ◽  
Fiber Type ◽  
Fiber Type Differentiation ◽  
Normal Fiber

A Second Look at Fiber Type Differentiation in Porcine Skeletal Muscle

1978 ◽  
Vol 46 (1) ◽  
pp. 125-132 ◽  
Author(s):  
D. H. Beermann ◽  
R. G. Cassens ◽  
G. J. Hausman
Keyword(s):  
Skeletal Muscle ◽  
Fiber Type ◽  
Second Look ◽  
Fiber Type Differentiation

Kynurenine aminotransferase isoforms display fiber-type specific expression in young and old human skeletal muscle

2020 ◽  
Vol 134 ◽  
pp. 110880 ◽  
Author(s):  
V.L. Wyckelsma ◽  
W. Lindkvist ◽  
T. Venckunas ◽  
M. Brazaitis ◽  
S. Kamandulis ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Fiber Type ◽  
Specific Expression ◽  
Kynurenine Aminotransferase

The KATP channel Kir6.2 subunit content is higher in glycolytic than oxidative skeletal muscle fibers

2011 ◽  
Vol 301 (4) ◽  
pp. R916-R925 ◽  
Author(s):  
Krystyna Banas ◽  
Charlene Clow ◽  
Bernard J. Jasmin ◽  
Jean-Marc Renaud
Keyword(s):  
Skeletal Muscle ◽  
Cross Sections ◽  
Fiber Type ◽  
Energy Levels ◽  
Muscle Fibers ◽  
Metabolic Stress ◽  
Oxidative Capacity ◽  
Fiber Types ◽  
Fiber Damage ◽  
The Individual

It has long been suggested that in skeletal muscle, the ATP-sensitive K+ channel (KATP) channel is important in protecting energy levels and that abolishing its activity causes fiber damage and severely impairs function. The responses to a lack of KATP channel activity vary between muscles and fibers, with the severity of the impairment being the highest in the most glycolytic muscle fibers. Furthermore, glycolytic muscle fibers are also expected to face metabolic stress more often than oxidative ones. The objective of this study was to determine whether the t-tubular KATP channel content differs between muscles and fiber types. KATP channel content was estimated using a semiquantitative immunofluorescence approach by staining cross sections from soleus, extensor digitorum longus (EDL), and flexor digitorum brevis (FDB) muscles with anti-Kir6.2 antibody. Fiber types were determined using serial cross sections stained with specific antimyosin I, IIA, IIB, and IIX antibodies. Changes in Kir6.2 content were compared with changes in CaV1.1 content, as this Ca2+ channel is responsible for triggering Ca2+ release from sarcoplasmic reticulum. The Kir6.2 content was the lowest in the oxidative soleus and the highest in the glycolytic EDL and FDB. At the individual fiber level, the Kir6.2 content within a muscle was in the order of type IIB > IIX > IIA ≥ I. Interestingly, the Kir6.2 content for a given fiber type was significantly different between soleus, EDL, and FDB, and highest in FDB. Correlations of relative fluorescence intensities from the Kir6.2 and CaV1.1 antibodies were significant for all three muscles. However, the variability in content between the three muscles or individual fibers was much greater for Kir6.2 than for CaV1.1. It is suggested that the t-tubular KATP channel content increases as the glycolytic capacity increases and as the oxidative capacity decreases and that the expression of KATP channels may be linked to how often muscles/fibers face metabolic stress.

scholarly journals Skeletal muscle fiber size and fiber type distribution in human cancer: Effects of weight loss and relationship to physical function

2016 ◽  
Vol 35 (6) ◽  
pp. 1359-1365 ◽  
Author(s):  
Michael J. Toth ◽  
Damien M. Callahan ◽  
Mark S. Miller ◽  
Timothy W. Tourville ◽  
Sarah B. Hackett ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Weight Loss ◽  
Physical Function ◽  
Muscle Fiber ◽  
Human Cancer ◽  
Fiber Type ◽  
Skeletal Muscle Fiber ◽  
Type Distribution ◽  
Fiber Size ◽  
Fiber Type Distribution
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