scholarly journals Myocardin-related transcription factor B is required for normal mouse vascular development and smooth muscle gene expression

2007 ◽  
Vol 236 (2) ◽  
pp. 416-425 ◽  
Author(s):  
Ke Wei ◽  
Nam Che ◽  
Fabian Chen
Keyword(s):  
Gene Expression ◽  
Transcription Factor ◽  
Smooth Muscle ◽  
Normal Mouse ◽  
Vascular Development ◽  
Factor B ◽  
Muscle Gene Expression ◽  
Related Transcription Factor ◽  
Muscle Gene

scholarly journals Kruppel-like Factor 4 Abrogates Myocardin-induced Activation of Smooth Muscle Gene Expression

2005 ◽  
Vol 280 (10) ◽  
pp. 9719-9727 ◽  
Author(s):  
Yan Liu ◽  
Sanjay Sinha ◽  
Oliver G. McDonald ◽  
Yueting Shang ◽  
Mark H. Hoofnagle ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Muscle Gene Expression ◽  
Muscle Gene

scholarly journals Requirement of a Myocardin-Related Transcription Factor for Development of Mammary Myoepithelial Cells

2006 ◽  
Vol 26 (15) ◽  
pp. 5797-5808 ◽  
Author(s):  
Shijie Li ◽  
Shurong Chang ◽  
Xiaoxia Qi ◽  
James A. Richardson ◽  
Eric N. Olson
Keyword(s):  
Transcription Factor ◽  
Smooth Muscle ◽  
Myoepithelial Cell ◽  
Serum Response Factor ◽  
Cell Lineage ◽  
Myoepithelial Cells ◽  
Embryonic Cell ◽  
Loss Of Function ◽  
Muscle Gene Expression ◽  
Related Transcription Factor

ABSTRACT The mammary gland consists of a branched ductal system comprised of milk-producing epithelial cells that form ductile tubules surrounded by a myoepithelial cell layer that provides contractility required for milk ejection. Myoepithelial cells bear a striking resemblance to smooth muscle cells, but they are derived from a different embryonic cell lineage, and little is known of the mechanisms that control their differentiation. Members of the myocardin family of transcriptional coactivators cooperate with serum response factor to activate smooth muscle gene expression. We show that female mice homozygous for a loss-of-function mutation of the myocardin-related transcription factor A (MRTF-A) gene are unable to effectively nurse their offspring due to a failure in maintenance of the differentiated state of mammary myoepithelial cells during lactation, resulting in apoptosis of this cell population, a consequent inability to release milk, and premature involution. The phenotype of MRTF-A mutant mice reveals a specific and essential role for MRTF-A in mammary myoepithelial cell differentiation and points to commonalities in the transcriptional mechanisms that control differentiation of smooth muscle and myoepithelial cells.

scholarly journals von Willebrand Factor Permeates Small Vessels in CADASIL and Inhibits Smooth Muscle Gene Expression

2011 ◽  
Vol 3 (1) ◽  
pp. 138-145 ◽  
Author(s):  
Xiaojie Zhang ◽  
He Meng ◽  
Mila Blaivas ◽  
Elisabeth J. Rushing ◽  
Brian E. Moore ◽  
...  
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Von Willebrand Factor ◽  
Small Vessels ◽  
Muscle Gene Expression ◽  
Muscle Gene ◽  
Von Willebrand ◽  
Willebrand Factor
Sign in / Sign up

Export Citation Format

Share Document