scholarly journals Subpopulations of motor and sensory neurons respond differently to brain-derived neurotrophic factor depending on the presence of the skeletal muscle

2006 ◽  
Vol 235 (8) ◽  
pp. 2175-2184 ◽  
Author(s):  
Allison J. Geddes ◽  
Heather E. Angka ◽  
Kimberley A. Davies ◽  
Boris Kablar
Keyword(s):  
Skeletal Muscle ◽  
Sensory Neurons ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

Injured primary sensory neurons switch phenotype for brain-derived neurotrophic factor in the rat

Neuroscience ◽  
1999 ◽  
Vol 92 (3) ◽  
pp. 841-853 ◽  
Author(s):  
X.-F. Zhou ◽  
E.T. Chie ◽  
Y.-S. Deng ◽  
J.-H. Zhong ◽  
Qing Xue ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Primary Sensory Neurons

Brain-derived neurotrophic factor stimulation of T-type Ca2+ channels in sensory neurons contributes to increased peripheral pain sensitivity

2019 ◽  
Vol 12 (600) ◽  
pp. eaaw2300 ◽  
Author(s):  
Hua Wang ◽  
Yuan Wei ◽  
Yichen Pu ◽  
Dongsheng Jiang ◽  
Xinghong Jiang ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Sensory Neurons ◽  
Neurotrophic Factor ◽  
Pain Sensitivity ◽  
Neuronal Excitability ◽  
Brain Derived Neurotrophic Factor ◽  
Mitogen Activated Protein Kinase ◽  
Mechanical Stimuli ◽  
Action Potential Firing ◽  
Stimulation Of

Although brain-derived neurotrophic factor (BDNF) is implicated in the nociceptive signaling of peripheral sensory neurons, the underlying mechanisms remain largely unknown. Here, we elucidated the effects of BDNF on the neuronal excitability of trigeminal ganglion (TG) neurons and the pain sensitivity of rats mediated by T-type Ca2+ channels. BDNF reversibly and dose-dependently enhanced T-type channel currents through the activation of tropomyosin receptor kinase B (TrkB). Antagonism of phosphatidylinositol 3-kinase (PI3K) but not of its downstream target, the kinase AKT, abolished the BDNF-induced T-type channel response. BDNF application activated p38 mitogen-activated protein kinase (MAPK), and this effect was prevented by inhibition of PI3K but not of protein kinase A (PKA). Antagonism of either PI3K or p38 MAPK prevented the BDNF-induced stimulation of PKA activity, whereas PKA inhibition blocked the BDNF-mediated increase in T-type currents. BDNF increased the rate of action potential firing in TG neurons and enhanced the pain sensitivity of rats to mechanical stimuli. Moreover, inhibition of TrkB signaling abolished the increased mechanical sensitivity in a rat model of chronic inflammatory pain, and this effect was attenuated by either T-type channel blockade or knockdown of the channel Cav3.2. Together, our findings indicate that BDNF enhances T-type currents through the stimulation of TrkB coupled to PI3K-p38-PKA signaling, thereby inducing neuronal hyperexcitability of TG neurons and pain hypersensitivity in rats.

Brain-Derived Neurotrophic Factor Could Regulate Mitochondrial Function in the Skeletal Muscle Through Ampk-Pgc1α Signaling in Heart Failure Mice

2015 ◽  
Vol 21 (10) ◽  
pp. S197
Author(s):  
Takayuki Nakajima ◽  
Shintaro Kinugawa ◽  
Shingo Takada ◽  
Junichi Matsumoto ◽  
Wataru Misushima ◽  
...  
Keyword(s):  
Heart Failure ◽  
Skeletal Muscle ◽  
Mitochondrial Function ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor
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